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Coronary plaque associated with poor gut bacteria (Might vitamin D or K help) – July 2023

Streptococcus Species Abundance in the Gut Is Linked to Subclinical Coronary Atherosclerosis in 8973 Participants From the SCAPIS Cohort

Circulation. 2023;0 https://doi.org/10.1161/CIRCULATIONAHA.123.063914
Sergi Sayols-Baixeras, Koen F. Dekkers, Gabriel Baldanzi, Daniel Jönsson, Ulf Hammar, Yi-Ting Lin, Shafqat Ahmad, Diem Nguyen, Georgios Varotsis, …

BACKGROUND:
Gut microbiota have been implicated in atherosclerotic disease, but their relation with subclinical coronary atherosclerosis is unclear. This study aimed to identify associations between the gut microbiome and computed tomography–based measures of coronary atherosclerosis and to explore relevant clinical correlates.

METHODS:
We conducted a cross-sectional study of 8973 participants (50 to 65 years of age) without overt atherosclerotic disease from the population-based SCAPIS (Swedish Cardiopulmonary Bioimage Study). Coronary atherosclerosis was measured using coronary artery calcium score and coronary computed tomography angiography. Gut microbiota species abundance and functional potential were assessed with shotgun metagenomics sequencing of stool, and associations with coronary atherosclerosis were evaluated with multivariable regression models adjusted for cardiovascular risk factors. Associated species were evaluated for association with inflammatory markers, metabolites, and corresponding species in saliva.

RESULTS:
The mean age of the study sample was 57.4 years, and 53.7% were female. Coronary artery calcification was detected in 40.3%, and 5.4% had at least 1 stenosis with >50% occlusion. Sixty-four species were associated with coronary artery calcium score independent of cardiovascular risk factors, with the strongest associations observed for Streptococcus anginosus and Streptococcusoralis subsp oralis (P<1×10–5). Associations were largely similar across coronary computed tomography angiography–based measurements. Out of the 64 species, 19 species, including streptococci and other species commonly found in the oral cavity, were associated with high-sensitivity C-reactive protein plasma concentrations, and 16 with neutrophil counts. Gut microbial species that are commonly found in the oral cavity were negatively associated with plasma indole propionate and positively associated with plasma secondary bile acids and imidazole propionate. Five species, including 3 streptococci, correlated with the same species in saliva and were associated with worse dental health in the Malmö Offspring Dental Study. Microbial functional potential of dissimilatory nitrate reduction, anaerobic fatty acid β-oxidation, and amino acid degradation were associated with coronary artery calcium score.

CONCLUSIONS:
This study provides evidence of an association of a gut microbiota composition characterized by increased abundance of Streptococcus spp and other species commonly found in the oral cavity with coronary atherosclerosis and systemic inflammation markers. Further longitudinal and experimental studies are warranted to explore the potential implications of a bacterial component in atherogenesis.
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VitaminDWiki – Microbiome contains

Some of the 38 Microbiome articles

VitaminDWiki – Overview Vitamin K and Vitamin D contains

Vitamin K2 is similar to D3 in many ways

  1. Both vitamins were initially confused with its lesser form (D2 ==> D3, K1 ==> K2)
  2. Both vitamins appear to influence health in large number of ways
  3. Both vitamins in the body are about 1/10 that of a century ago
    Example: Grass-fed beef has a lot more K2, D3, and Magnesium
  4. Need very little of both vitamins: <1 milligram daily
  5. When Vitamin D3 is increased, it appears that Vitamin K2 should also be increased
  6. Vitamin K2 understanding and research is about 20 years behind that of Vitamin D3
    One of the reasons: No simple blood test for K2 as of Jan 2020
Note: There is a strong synergy between good gut bacteria and both Vitamin D and Vitamin K
Note: Vitamin K decreases and even dissolves coranary plaque

72+ VitaminDWiki pages with ARTERIES OR ATHEROSCLEROSIS OR CALCIFICATION in title

This list is automatically updated

Items found: 74
Title Modified
Less Calcification if less Calcium or more Vitamin K, Magnesium, etc. - many studies 26 May, 2024
Gynecological cancers and atherosclerosis (perhaps a Vitamin D association) - Dec 2023 29 Jan, 2024
Coronary Artery Disease and Vitamin D - many studies 20 Sep, 2023
Vitamin K2-7 decreases arterial stiffness (cleans arteries) – RCT Feb 2015 20 Jul, 2023
Arteries and Atherosclerosis and Vitamin D - many studies 03 Jul, 2023
Childhood Cancer Survivors have worse arteries due to anticancer therapy – May 2023 30 May, 2023
Vascular calcification greatly reduced by 3 per week 1000 ug of Vitamin K2 MK-7 – Dec 2013 14 Apr, 2023
Coronary Artery Disease Chest Pain, Anxiety, and Fatigue associated with low vitamin D – Oct 2022 07 Oct, 2022
Vitamin D fights Coronary Artery Disease in many ways – when will it be used in therapy – May 2022 13 May, 2022
Arterial Stiffness and Vitamins – only Vitamin D was found to help – meta-analysis Feb 2022 27 Feb, 2022
Low Vitamin D and Vitamin K: brittle bones and hardened arteries – LEF Sept 2010 14 Oct, 2021
Coronary Artery Disease 2.9 X more likely in postmenopausal women if Vitamin D deficient – March 2020 19 Mar, 2020
Arterial stiffness reduced if use at least 2,000 IU of Vitamin D for 4 months – meta-analysis Dec 2019 06 Dec, 2019
Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019 02 Jul, 2019
Hard bones, soft arteries, rather than vice versa (Vitamin D and Vitamin K) – March 2016 26 Apr, 2019
Vitamin K reduces calcification (reported yet again) – Feb 2019 01 Feb, 2019
Innocent Dietary Imbalance Hardens and Narrows Your Arteries (Omega-3 index) – Dec 2018 10 Dec, 2018
Hypothesis – Vascular calcification is associated with both too much and too little vitamin D - May 2018 15 Jul, 2018
Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018 21 Apr, 2018
Arterial stiffness reduced by vitamin D 04 Apr, 2018
Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018 29 Mar, 2018
Hypothesis – Use of anticoagulants with COPD lowers Vitamin K, which increases calcification – Nov 2017 25 Jan, 2018
Arterial stiffness reduced by Omega-3, Vitamin D, Vitamin K2, Magnesium, etc. 06 Jan, 2018
Arterial stiffness reduced by Omega-3, Vitamin D, Vitamin K, Potassium, etc. 05 Jan, 2018
Coronary Artery Disease risk both increased and decreased by 30 percent with mutations in Vitamin D Binding – April 2016 09 Nov, 2017
Intracranial arterial calcification in 85 percent of ischemic strokes (Vitamin K and Vitamin D should help) – Oct 2017 27 Oct, 2017
Vitamin D Binding Protein and Coronary artery disease – Oct 2017 26 Oct, 2017
Obstructive coronary artery disease 2.9 X more likely if chest pain and low vitamin D – Aug 2016 09 Aug, 2017
Cardiovascular calcification prevented by Omega-3, Magnesium, Vitamin K, and Vitamin D – April 2015 09 Aug, 2017
Stiff arteries 6.8 X more likely if low vitamin D AND low vitamin K – April 2017 10 May, 2017
7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013 20 Mar, 2017
Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016 10 Dec, 2016
Atherosclerosis prevented by Ultraviolet light (UVB in mice) – Oct 2016 25 Nov, 2016
Hypothesis: Atherosclerosis in Ancient and Modern Humans due to low vitamin D (behind paywall) - May 2015 25 Nov, 2016
Atherosclerosis – higher risk due to low vitamin D than HDL – Feb 2015 25 Nov, 2016
Peripheral Arterial Disease 2 percent more likely for every 1 nanogram less Vitamin D – Sept 2016 01 Oct, 2016
Peripheral Arterial Disease patients have low vitamin D levels – meta-analysis Oct 2015 01 Oct, 2016
Coronary artery calcification associated with low vitamin D 18 Jun, 2016
Vitamin D deficiency was the highest risk factor for coronary artery calcification with HIV -Aug 2013 18 Jun, 2016
Magnesium reduced calcitriol (active vitamin D) artery calcification in CKD by 50 percent – Oct 2015 22 Oct, 2015
Peripheral Arterial Disease 3X less prevalent at 40 ng of vitamin D – 2008 15 Oct, 2015
Vitamin D and peripheral arterial disease – Nov 2011 15 Oct, 2015
Reverse Hardening of the Arteries with vitamin K2 -2015 29 Sep, 2015
Vitamin D video: calcification, narrow-band UV, 4,000 IU, 50 ng – Dr. DeLuca May 2015 04 Jun, 2015
If you must take statins and want to avoid hardening of arteries, take vitamin K2 – RCT May 2015 22 May, 2015
7100 IU vitamin D2 for 3 months did not treat Coronary Artery Disease – Nov 2012 16 Mar, 2015
Children with low vitamin D were 1.8 X more likely to have poor arteries 27 years later – Feb 2015 11 Feb, 2015
Vitamin D Deficiency may be an Independent Risk Factor for Arterial Disease – July 2012 03 Feb, 2015
Arterial stiffness reduced by a single dose of 100,000 IU of vitamin D – RCT Dec 2014 06 Jan, 2015
Vitamin D is good, but must balance Vitamins A and K2 to prevent Calcification – Masterjohn Aug 2014 31 Dec, 2014
Coronary Artery Enlargement associated with low levels of vitamin D – Nov 2014 10 Dec, 2014
Interactions of Vitamins D, A, and K, should measure calcitriol, calcification – Masterjohn Aug 2013 28 Nov, 2014
Arterial stiffness reduced with vitamin D intervention – June 2011 21 Sep, 2014
Stiff arteries in seniors associated with low vitamin D levels – July 2012 21 Sep, 2014
Soft Bones, Hard Arteries, Vitamin D, Vitamin K2 and antibiotics – Sept 2012 20 Jul, 2014
Magnesium Suppresses Formation of Clogged Arteries - May 2014 08 May, 2014
Coronary artery disease extent is associated with extent of vitamin D deficiency – April 2014 04 Apr, 2014
Atherogenesis, atherosclerosis and vitamin D – review Dec 2013 21 Feb, 2014
Vascular calcification in chronic kidney disease April 2010 21 Dec, 2013
24X less Calcification of Aorta for PAD with modest level of vitamin D – Aug 2011 21 Dec, 2013
Aortic Calcification 85 percent more likely if vitamin D level lower than 29 ng – June 2012 21 Dec, 2013
Vitamin D significantly lowers macrophage adhesion to prevent arterial clots (in diabetics)– Nov 2012 07 Oct, 2013
Coronary artery disease 5.8X more likely if vitamin D level is less than 30 ng – Nov 2012 24 Sep, 2013
Excess vitamin A caused calcification of heart valves in mice – Dec 2012 17 Jul, 2013
Vitamin D and Arterial Hypertension: Treat the Deficiency - Feb 2013 06 Feb, 2013
Vertebral fracture 3X more likely with aortic calcification – Vitamins D3 and K2 Sept 2012 17 Oct, 2012
Coronary Artery Disease predicted by low levels of vitamin D – April 2012 16 Oct, 2012
Petrie dish experiment confirms that active vitamin D reduces arterial inflammation – Aug 2012 23 Aug, 2012
Old concern about high vitamin D and atherosclerosis – 2003 08 Apr, 2012
Vitamin D deficient Type 1 diabetics 3X more likely to have calcification problems – Feb 2011 28 Oct, 2011
Low vitamin D may contribute to Peripheral Arterial Disease – June 2010 30 Aug, 2011
Vitamin D is a promising way to deal with atherosclerosis – Aug 2010 03 Jul, 2011
Atherosclerosis associated with low vitamin D – June 2011 03 Jul, 2011
Vitamin D might deal with atherosclerosis – Jan 2011 03 Jul, 2011

Coronary plaque associated with poor gut bacteria (Might vitamin D or K help) – July 2023        
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