Toggle Health Problems and D

Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019

Vitamin D deficiency is associated with risk of developing peripheral arterial disease in type 2 diabetic patients

BMC Cardiovascular Disorders 201919:145, https://doi.org/10.1186/s12872-019-1125-0
Jing Yuan, Pu Jia, Lin Hua, Zhong Xin and Jin-Kui Yang Email author


Items in both categories Cardiovascular and Diabetes are listed here:

Grassroots Health plot of the data

 Download the PDF from VitaminDWiki

The relationship between vitamin D levels and peripheral arterial disease (PAD) remains unclear. We assessed the association of serum 25-hydroxyvitamin D (25(OH)D) levels with the prevalence of PAD in patients with type 2 diabetes mellitus(T2DM).

A total of 1018 T2DM patients participated in this cross-sectional study. Serum 25(OH)D levels were measured and risk factors of PAD were recorded. PAD was diagnosed as an ankle-brachial index (ABI) < 0.9.

The mean age of the diabetic patients was 58.59 ± 11.34 years. Of all the patients, only 20.1% had a 25(OH)D level ≥ 20 ng/mL. Compared to patients without PAD, serum 25(OH)D levels were significantly lower in those with PAD (14.81 ± 8.43 vs. 11.55 ± 5.65 ng/mL, P < 0.001). The overall prevalence of PAD was 7.7%. From the highest level (≥ 20 ng/mL) to the lowest level (< 10 ng/mL) of serum 25(OH)D, the prevalence of PAD was 2.8, 7.5 and 10.7% respectively. After adjustment for age, sex, body mass index (BMI), smoking status and season, compared to patients with serum 25(OH)D levels ≥20 ng/mL, the odds ratios of PAD in patients with a level of 10 to < 20 ng/mL and < 10 ng/mL was 3.587(95% CI: 1.314–9.790) and 5.540(95% CI: 2.004–15.320), respectively. When further considering the influence of coronary heart disease (CHD), hypertension and cerebral infarction, the ratios changed to 3.824(95% CI: 1.378–10.615) and 5.729(95% CI: 2.028–16.187), respectively. And after further adjustment for the duration of diabetes, glycated hemoglobin (HbA1c) and glomerular filtration rate (GFR), the ratios changed to 3.489(95% CI: 1.100–11.062) and 3.872(95% CI: 1.168–12.841), respectively.

Reduced serum vitamin D levels were associated with an increased risk of PAD in T2DM patients. Randomized interventive clinical studies are required to verify the effects of vitamin D supplementation on PAD

Created by admin. Last Modification: Tuesday July 2, 2019 11:24:00 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
12252 PAD T2D GRH.jpg admin 02 Jul, 2019 60.81 Kb 511
12251 PAD T2D.pdf admin 02 Jul, 2019 814.89 Kb 458