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Coronary Artery Disease risk both increased and decreased by 30 percent with mutations in Vitamin D Binding – April 2016

Investigation of Vitamin D-Binding Protein Polymorphism Impact on Coronary Artery Disease and Relationship with Longevity: Own Data and a Review.

Int J Endocrinol. 2016;2016:8347379. doi: 10.1155/2016/8347379. Epub 2016 Apr 6.
Stakisaitis D1, Lesauskaitė V2, Girdauskaitė M3, Janulionis E4, Ulys A5, Benetis R6.


Cardiovascular category starts with the following

410 items In Cardiovascular category

Items in both categories Cardiovascular and VDBP are listed here:

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The aim of the study was to assess the effect of vitamin D-binding protein (DBP) polymorphism on coronary artery disease (CAD). DBP phenotypes were identified in the groups: control (n = 306), men suffering from CAD (n = 154), and long-lived individuals (n = 108). Isoelectric focusing of DBP phenotypes in serum was performed on polyacrylamide gel. Distribution of DBP phenotypes in the study groups was found to be in Hardy-Weinberg equilibrium. Gc1s-1s phenotype and Gc1s allele frequency in CAD groups were significantly higher than in control, and Gc1s allele frequency was found significantly more often in CAD compared with long-lived group (p < 0.05). The Gc2 allele frequency in control was higher as compared with Gc2 frequency in CAD group (p < 0.05). The Gc2-2 phenotype was more frequent in long-lived survivors than in the CAD group (p < 0.05). It was found that the Gc1s allele significantly increased the risk of CAD with the odds ratio (OR) equal to 1.45 (p < 0.02) and showed Gc2 to be related with a decreased risk of CAD (OR = 0.69; p < 0.03). Authors review the role of DBP in resistance to atherosclerosis and cancer as the main longevity determinants.

PMID: 27143969 PMCID: PMC4837253 DOI: 10.1155/2016/8347379

Created by admin. Last Modification: Thursday November 9, 2017 19:38:05 GMT-0000 by admin. (Version 2)

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ID Name Comment Uploaded Size Downloads
8671 DBP and CAD.pdf admin 09 Nov, 2017 19:35 538.40 Kb 177
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