Interactions of Vitamins D, A, and K, should measure calcitriol, calcification – Masterjohn Aug 2013

"Fat-Soluble Vitamin Interactions: An Ancestral Perspective."

Talk by Chris Masterjohn presented at Ancestral Health Symposium
YouTube Audio (video in the future)

(Audio file is attached to the bottom of this page)

The central theme will be that altogether too much focus has been placed on obtaining optimal serum 25(OH)D as a marker of vitamin D status, and while looking at 25(OH)D is useful, we need to shift the greater emphasis towards looking at interactions with other nutrients, especially vitamins A and K, both clinically and in research, a phenomenon that has been mostly neglected.

I will start out by critiquing what I call the "naked ape" hypothesis of optimal serum 25(OH)D concentrations, move on to question whether there is such a thing as an optimal 25(OH)D concentration, show why 25(OH)D is not a specific marker of vitamin D input despite being commonly used that way, and discuss numerous factors besides vitamin D that affect 25(OH)D.

This will include an argument that calcitriol should be measured together with 25(OH)D in order to provide more information.

I will then argue that the current trend to promote vitamin D supplementation, without adequate attention to vitamins A and K, and sometimes even coupled to recommendations to limit or decrease vitamin A intake, has the potential to promote pathological soft tissue calcification.

I will conclude by discussing the interactions among these vitamins and arguing that obtaining these vitamins together, as they would have occurred in ancestral diets, makes them most safe and effective.

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See also VitaminDWiki

• 14 items with Masterjohn in the title as of Sept 2021
• Synergism between Vitamin D, Vitamin K-2, and Vitamin A: Masterjohn – Sept 2013
• Cholesterol, Vitamins D3 and K2, heart disease, sulfates, LDL, – Masterjohn Interview Jan 2013
• All items in category Vitamin A 70 items
• All items in category Vitamin K2 158 items
• Overview Vitamin K and Vitamin D
• Calcitriol, not inactive vitamin D, associated with pain in seniors – Aug 2014
• Vitamin D3 becomes Calcidiol which becomes Calcitriol

Note: Caclitriol is the output of the kidney/Paracrine system