Loading...
 
Translate Register Log In Login with facebookLogin and Register

Hypothesis – Vascular calcification is associated with both too much and too little vitamin D - May 2018

Vitamin D in Vascular Calcification: A Double-Edged Sword?

Nutrients 2018, 10(5), 652; https://doi.org/10.3390/nu10050652
Jeffrey Wang 1, Jimmy J. Zhou 1,2, Graham R. Robertson 3 and Vincent W. Lee 1
1 Centre for Transplantation and Renal Research, Westmead Institute of Medical Research, Westmead, NSW 2145, Australia
2 Centre for Kidney Research, Children’s Hospital at Westmead, Westmead, NSW 2145, Australia
3 Cellmid Limited, 2/55 Clarence St, Sydney, NSW 2000, Australia

 Download the PDF from VitaminDWiki
Image

Vascular calcification (VC) as a manifestation of perturbed mineral balance, is associated with aging, diabetes and kidney dysfunction, as well as poorer patient outcomes. Due to the current limited understanding of the pathophysiology of vascular calcification, the development of effective preventative and therapeutic strategies remains a significant clinical challenge. Recent evidence suggests that traditional risk factors for cardiovascular disease, such as left ventricular hypertrophy and dyslipidaemia, fail to account for clinical observations of vascular calcification. Therefore, more complex underlying processes involving physiochemical changes to mineral balance, vascular remodelling and perturbed hormonal responses such as parathyroid hormone (PTH) and fibroblast growth factor 23 (FGF-23) are likely to contribute to VC. In particular, VC resulting from modifications to calcium, phosphate and vitamin D homeostasis has been recently elucidated. Notably, deregulation of vitamin D metabolism, dietary calcium intake and renal mineral handling are associated with imbalances in systemic calcium and phosphate levels and endothelial cell dysfunction, which can modulate both bone and soft tissue calcification. This review addresses the current understanding of VC pathophysiology, with a focus on the pathogenic role of vitamin D that has provided new insights into the mechanisms of VC.

Created by admin. Last Modification: Sunday July 15, 2018 08:29:34 GMT-0000 by admin. (Version 2)

Attached files

ID Name Comment Uploaded Size Downloads
10189 Vascular calcification.jpg admin 15 Jul, 2018 08:28 35.91 Kb 129
10188 Vascular Calcification.pdf PDF 2018 admin 15 Jul, 2018 08:27 566.67 Kb 59
See any problem with this page? Report it (FINALLY WORKS)