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Coronary artery disease extent is associated with extent of vitamin D deficiency – April 2014

VITAMIN D DEFICIENCY IS INDEPENDENTLY ASSOCIATED WITH THE EXTENT OF CORONARY ARTERY DISEASE

A1602 JACC April 1, 2014 Volume 63, Issue 12
Poster Contributions, Hall C, Sunday, March 30, 2014, 3:45 p.m.-4:30 p.m.
Session Title: Stable Ischemic Heart Disease: Basic Science II Abstract Category: 24. Stable lschemic Heart Disease: Basic Pmentation Number: 1230-329
Authors: Monica Verdoia Alon Schaffer, Lucia Barbieri, Ettore Cassetti, Paolo Marino, Giuseppe De Luca, Ospedale Maggiore della Carita, Universita del Piemonte Orientate, Novara, Italy

Background: Vitamin D (25-0H D3) deficiency represents a rising problem in Western countries. Vitarnin D has been recently reported to regulate idammatory process, vascular cells proliferation and even platelet function, with contrasting results on its role on atherothrombosis.We, therefore, aimed to assess the relationship between 25-0H D3 and the extent of coronary artery disease (CAD) in a consecutive cohort of patients undergoing coronary angiography.

Methods: In 1484 patients fasting samples were collected for 25-0H D3 levels. Hypovitaminosis D was defined for values <30 ng/mL, (lower limit normal), and severe deficiency if <15ng/mL. CAD was considered as at least 1 vessel stenosis > 50,, while severe CAD for lett main and/or trivessel disease, as evaluated by Q..

Results: Hypovitaminosis D was observed in 91.8 % of patients..
Dividing our population according to vitamin D tertiles values (<9.6; >18.4), lower levels related with

  • aging,
  • female gender (p<0.001, respectively),
  • renal failure (p-0.05),
  • active smoking (p-0.001),
  • acute coronary syndrome at presentation (p<0.001),
  • therapy with calcium antagonists (p-0.02) and
  • diuretics (p<0.001),
  • less beta-blockers (p-0.02) and
  • stafins (p-0.001) use.

Vitamin D

  • directly related with haemoglobin (p<0.001) and
  • inversely with platelet count (p-0.002),
    total and LDL cholesterol (p-0.002 and p<0.001) and
    triglycerides (p-0.01).

Hypovitaminosis D was related with higher prevalence of left main and right coronary artery disease (p-0.03).
Vitamin D deficiency was associated with higher prevalence of CAD 1.32 and severe CAD 1.81. Moreover, an additional CAD risk was found in patients with severe rather than mild vitamin D deficiency (16 – 30 ng/m1) OR 2.11 and adjusted. OR 1.7 compared with normal).

Conclusions: Hypovitaminosis D is observed in the vast majority of patients undergoing coronary angiography.Vitamin D deficiency is significantly associated with the extent of CAD, with higher risk for values < 15 ng/ml.


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See also VitaminDWiki

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