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Radiation therapy for cancer should be helped by Vitamin D – April 2021

Immune Response: A Missed Opportunity Between Vitamin D and Radiotherapy

Review Front Cell Dev Biol . 2021 Apr 13;9:646981. doi: 10.3389/fcell.2021.646981
Xinyue Yu 1, Baocai Liu 1, Ning Zhang 1, Qian Wang 1, Guanghui Cheng 1
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VitaminDWiki

As with Chemotherapy, may need to reduce the amount of radiation therapy when Vitamin D levels are increased
see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=396
         click on chart for details


Note: To be of a benefit, Vitamin D levels need to be raised BEFORE radiation therapy
A large vitamin D loading dose can restore Vitamin D levels in 10 days

Loading Dose of Vitamin D category has the following

171 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Injection category listing has 58 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses

The TOP articles in Loading Dose of Vitamin D are listed here:

 Download the PDF from VitaminDWiki

Radiotherapy (RT) is a mainstay treatment in several types of cancer and acts by mediating various forms of cancer cell death, although it is still a large challenge to enhance therapy efficacy. Radiation resistance represents the main cause of cancer progression, therefore, overcoming treatment resistance is now the greatest challenge for clinicians. Increasing evidence indicates that immune response plays a role in reprogramming the radiation-induced tumor microenvironment (TME). Intriguingly, radiation-induced immunosuppression possibly overwhelms the ability of immune system to ablate tumor cells. This induces an immune equilibrium, which, we hypothesize, is an opportunity for radiosensitizers to make actions.

Vitamin D has been reported to act in synergistic with RT by potentiating antiproliferative effect induced by therapeutics. Additionally, vitamin D can also regulate the TME and may even lead to immunostimulation by blocking immunosuppression following radiation. Previous reviews have focused on vitamin D metabolism and epidemiological trials, however, the synergistic effect of vitamin D and existing therapies remains unknown.
This review summarizes vitamin D mediated radiosensitization, radiation immunity, and vitamin D-regulated TME, which may contribute to more successful vitamin D-adjuvant radiotherapy.


Created by admin. Last Modification: Saturday May 1, 2021 02:18:34 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
15539 Radiation therapy.jpg admin 01 May, 2021 01:47 62.42 Kb 101
15538 Radiation theraphy could be helped by vitamin D.pdf PDF 2021 admin 01 May, 2021 01:47 798.43 Kb 26
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