Cancer patients need more vitamin D, even those who are supplementing – observational study June 2021

Cross-sectional observational study - Investigation of vitamin D concentration in Caucasian cancer patients. what is the adequate dose of vitamin D for these patients?

Clin Nutr. 2021 Apr 22;40(6):3852-3858.
Aleksandra Kapała 1, Małgorzata Szlendak 2, Ewelina Grochowska 3


Many people would not have gotten cancer if they had taken enough Vitamin D years earlier

derived from Grassroots 2013

  • click on chart for details

This study ignored those with dark skins - who often have bigger problems with Cancer

vs White
White - low D
vs White - high D
breast cancer 1.34 1.26
colorectal cancer 1.43 1.44
cardiovascular disease1.29 1.27
all-cause mortality 1.26 1.26

Many doctors prescribe enough vitamin d for healthy people - post-surgery and chemo patients need much more

Vitamin D even helps after the doctor has given up

Should consider prehabilitation - take Vitamin D BEFORE surgery

Loading doses of Vitamin D are sometimes used before/after surgeries

Cancer category starts with the following

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

Vitamin D Receptor activation can be increased by any of: Resveratrol,  Omega-3,  MagnesiumZinc,   Quercetin,   non-daily Vit D,  Curcumin, intense exercise,   Ginger,   Essential oils, etc  Note: The founder of VitaminDWiki uses 10 of the 12 known VDR activators

Vitamin D levels drop a lot for a few months following any surgery

Vitamin D measured before surgery is not a good indicator of how much vitamin d is needed

Vitamin D levels should be > 40 ng or higher at all times

Publisher wants $36 for the PDF

2 charts from Google images


Background & aims: Vitamin D impairs tumour-related transformation and supports the anticancer function of the immune system. Currently, there are no guidelines on vitamin D supplementation devoted solely to cancer patients. The primary objective of the study was to evaluate the frequency of vitamin D deficiency in Caucasian cancer patients and to characterize the clinical factors that predispose individuals to decreased vitamin D concentration. Secondly, the study aimed to estimate the dose of vitamin D supplementation that would prevent deficiencies in patients with cancer.

Methods: In the presented cross-sectional study the population consisted of 500 consecutive Caucasian patients with a diagnosis of neoplastic disease, some of which declared long-term vitamin D supplementation in various doses. Serum vitamin D concentration was measured once in all patients and clinical data were obtained from the hospital database. The frequencies of vitamin D deficiency were compared to certain clinical variables by appropriate statistical tests. The dose of vitamin D substitution in cancer patients was estimated using the receiver operating characteristic (ROC) curve.

Results:Vitamin D deficiency was diagnosed in 66.8% of patients with cancer and even in 31.6% who declared vitamin D supplementation. Older age, male gender, diagnosis of head and neck cancer or squamous cell carcinoma and body mass loss were identified as factors that predispose to vitamin D deficiency. The dose of vitamin D that would prevent deficiency in Caucasian patients with cancer was set at 2250 IU daily.

Conclusions: Vitamin D deficiency was very common in Caucasian patients with cancer, even in terms of vitamin D supplementation. The greatest predisposition was related to elder age, male gender, diagnosis of head and neck or squamous cell carcinoma and body mass loss. The dose of vitamin D supplementation in cancer patients should probably be higher than in the general population.


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