Toggle Health Problems and D

Vitamin D prevents and treats cancer in many ways – May 2021

Newly-identified Pathways Relating Vitamin D to Carcinogenesis: A Review

In Vivo May 2021, 35 (3) 1345-1354; DOI: https://doi.org/10.21873/invivo.12387


Cancer category starts with the following

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

The review on this page does not appear to mention the Vitamin D Receptor. which is very important in many Cancers

 Download the PDF from VitaminDWiki

Background: The epidemiological relationship between vitamin D levels and cancer has been thoroughly investigated. Published data from large studies appear to corroborate a significant relationship between higher serum vitamin D concentrations and improved survival. Mechanistic reviews on commonly-studied cancers – including breast cancer, colon cancer and melanoma – focus predominantly on data from older studies. In outlining avenues for future research, we believe there is utility in summarizing novel findings introduced to the literature.

Materials and Methods: In this narrative review, we used MEDLINE, PUBMED and Cochrane databases to identify mechanistic studies published from January 1, 2015 onwards exploring this topic.

Results: Twenty-five mechanistic studies were included in this review. It was found that vitamin D plays a critical role in both

  • direct
    • tumor gene expression, proliferation, invasiveness, sensitivity to chemotherapy etc. and
  • indirect
    • effects on the tumor microenvironment and immunomodulation)

tumor suppression mechanisms.

Conclusion: These newly-identified pathways warrant further research, with the hopes that we may understand how and when vitamin D supplementation can be integrated into precision medicine therapeutics for cancers of the breast, colon and skin. Cancer care providers should consider recommendations to screen for vitamin D deficiency in this population.

Created by admin. Last Modification: Wednesday June 16, 2021 22:05:13 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
15532 Cancer prevent and treat.jpg admin 29 Apr, 2021 12:15 151.27 Kb 461
15531 Direct and indirect ways Vitamin D stops cancer.pdf PDF 2021 admin 29 Apr, 2021 12:15 1.62 Mb 211