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Taking Vitamin D just before and after surgery helps (open-heart in this case) – RCT Feb 2021

Vitamin D supplementation protects against reductions in plasma 25-hydroxyvitamin D induced by open-heart surgery: Assess-d trial

Physiol Rep. 2021 Feb;9(3):e14747. doi: 10.14814/phy2.14747.
Tyler Barker 1 2, Heidi T May 3, John R Doty 3 4, Donald L Lappe 3 4, Kirk U Knowlton 3 4, John Carlquist 3, Kristin Konery 3, Shannon Inglet 3, Ben Chisum 3, Oxana Galenko 3, Jeffrey L Anderson 3 4, Joseph B Muhlestein 3 4

VitaminDWiki

This study gave 50,000 IU of vitamin D the night before and the 2 days after the surgery
There would probably be more benefit to the body
   if the same amount were given several days before the surgery,
   as it takes the body a while to utilize the vitamin D
     >200.000 IU total in the week before a surgery would be good

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Personal note: 200,000 IU vitamin D helped my 100 year old in ICU
My 100 year-old father-in-law had sepsis while in the ICU
I gave him 200,000 IU of vitamin D - without the doctor's knowledge
He was kicked out of the ICU and hospital 3 days later - sepsis gone and he was all recovered

 Download the PDF from VitaminDWiki
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150,000 IU given late showed minimal benefit
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Low vitamin D (serum or plasma 25-hydroxyvitamin D OH)D is a global pandemic and associates with a greater prevalence in all-cause and cardiovascular mortality and morbidity. Open-heart surgery is a form of acute stress that decreases circulating 25(OH)D concentrations and exacerbates the preponderance of low vitamin D in a patient population already characterized by low levels. Although supplemental vitamin D increases 25(OH)D, it is unknown if supplemental vitamin D can overcome the decreases in circulating 25(OH)D induced by open-heart surgery. We sought to identify if supplemental vitamin D protects against the acute decrease in plasma 25(OH)D propagated by open-heart surgery during perioperative care.

Participants undergoing open-heart surgery were randomly assigned (double-blind) to one of two groups: (a) vitamin D (n = 75; cholecalciferol, 50,000 IU/dose) or (b) placebo (n = 75). Participants received supplements on three separate occasions: orally the evening before surgery and either orally or per nasogastric tube on postoperative days 1 and 2. Plasma 25(OH)D concentrations were measured at baseline (the day before surgery and before the first supplement bolus), after surgery on postoperative days 1, 2, 3, and 4, at hospital discharge (5-8 days after surgery), and at an elective outpatient follow-up visit at 6 months.

Supplemental vitamin D abolished the acute decrease in 25(OH)D induced by open-heart surgery during postoperative care. Moreover, plasma 25(OH)D gradually increased from baseline to day 3 and remained significantly increased thereafter but plateaued to discharge with supplemental vitamin D. We conclude that perioperative vitamin D supplementation protects against the immediate decrease in plasma 25(OH)D induced by open-heart surgery. ClinicalTrials.gov Identifier: NCT02460211.


Created by admin. Last Modification: Sunday February 14, 2021 13:26:33 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
15045 Open Heart Table 6.jpg admin 14 Feb, 2021 13:23 64.24 Kb 30
15044 Before surgery.jpg admin 14 Feb, 2021 13:19 45.87 Kb 50
15043 Before open-heart.pdf PDF 2021 admin 14 Feb, 2021 13:18 536.99 Kb 12
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