Vitamin D supplementation protects against reductions in plasma 25-hydroxyvitamin D induced by open-heart surgery: Assess-d trial
Physiol Rep. 2021 Feb;9(3):e14747. doi: 10.14814/phy2.14747.
Tyler Barker 1 2, Heidi T May 3, John R Doty 3 4, Donald L Lappe 3 4, Kirk U Knowlton 3 4, John Carlquist 3, Kristin Konery 3, Shannon Inglet 3, Ben Chisum 3, Oxana Galenko 3, Jeffrey L Anderson 3 4, Joseph B Muhlestein 3 4
This study gave 50,000 IU of vitamin D the night before and the 2 days after the surgery
There would probably be more benefit to the body
if the same amount were given several days before the surgery,
as it takes the body a while to utilize the vitamin D
>200.000 IU total in the week before a surgery would be good
- Half as many problems if take Vitamin D (300,000 IU) before thyroid surgery – RCT Jan 2021
- Off topic: Improving your health BEFORE surgery (prehabilitation) helps your recovery - 2018
- '':In many cases taking Vitamin D years before would have elminated the need for the surgery
- Vitamin D is needed before most surgeries – many studies and RCTs
Trauma and surgery category starts with the followingTrauma and Surgery category has
see also Concussions
Overview Fractures and Falls and Vitamin D
Cancer - After diagnosis chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Search VitaminDWiki for cathelecidin OR hCAP18 219 items as of March 2020
Search VitaminDWiki for ICU OR “critical care” OR “intensive care” OR “acute care”
1740 items as of May 2019
Search VitaminDWiki for transplant 794 items as of Jan 2018
Trauma and Surgery is associated with 22 other VitaminDWiki categories
Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022
Personal note: 200,000 IU vitamin D helped my 100 year old in ICU
My 100 year-old father-in-law had sepsis while in the ICU
I gave him 200,000 IU of vitamin D - without the doctor's knowledge
He was kicked out of the ICU and hospital 3 days later - sepsis gone and he was all recovered
150,000 IU given late showed minimal benefit
Low vitamin D (serum or plasma 25-hydroxyvitamin D OH)D is a global pandemic and associates with a greater prevalence in all-cause and cardiovascular mortality and morbidity. Open-heart surgery is a form of acute stress that decreases circulating 25(OH)D concentrations and exacerbates the preponderance of low vitamin D in a patient population already characterized by low levels. Although supplemental vitamin D increases 25(OH)D, it is unknown if supplemental vitamin D can overcome the decreases in circulating 25(OH)D induced by open-heart surgery. We sought to identify if supplemental vitamin D protects against the acute decrease in plasma 25(OH)D propagated by open-heart surgery during perioperative care.
Participants undergoing open-heart surgery were randomly assigned (double-blind) to one of two groups: (a) vitamin D (n = 75; cholecalciferol, 50,000 IU/dose) or (b) placebo (n = 75). Participants received supplements on three separate occasions: orally the evening before surgery and either orally or per nasogastric tube on postoperative days 1 and 2. Plasma 25(OH)D concentrations were measured at baseline (the day before surgery and before the first supplement bolus), after surgery on postoperative days 1, 2, 3, and 4, at hospital discharge (5-8 days after surgery), and at an elective outpatient follow-up visit at 6 months.
Supplemental vitamin D abolished the acute decrease in 25(OH)D induced by open-heart surgery during postoperative care. Moreover, plasma 25(OH)D gradually increased from baseline to day 3 and remained significantly increased thereafter but plateaued to discharge with supplemental vitamin D. We conclude that perioperative vitamin D supplementation protects against the immediate decrease in plasma 25(OH)D induced by open-heart surgery. ClinicalTrials.gov Identifier: NCT02460211.
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