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Recurrent pregnancy loss (miscarriage) is associated with low vitamin D in 6 ways – March 2021

A novel update on vitamin D in recurrent pregnancy loss (Review)

Mol Med Rep. 2021 May;23(5):382. doi: 10.3892/mmr.2021.12021
Haoyu Zhao 1, Xiaoqi Wei 2, Xiuhua Yang 2


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Recurrent pregnancy loss (RPL) is usually characterized as ≥3 miscarriages before 20 weeks of gestation. Patients with RPL may have autoimmune abnormalities or alloimmune problems. Vitamin D has a major function on the mechanism of immunomodulation at the maternal-fetal interface. However, whether vitamin D can be used as an effective method to treat patients with RPL requires investigation. It has been reported that vitamin D could prevent the occurrence of antiphospholipid syndrome (APS) by reducing the expression levels of anti-β2 glycoprotein and tissue factor in RPL cases with APS. In addition, there is an opposite relationship between vitamin D and thyroid peroxidase antibody levels in autoimmune thyroid disease cases with RPL. Vitamin D changes the ratio of T helper (Th) 1/Th2 and regulatory T cell/Th17 to a certain extent, as well as affects the activity of natural killer cells and the production of cytokines to reduce the incidence of RPL. The objective of the current review was to address the research progress of vitamin D in RPL in recent years, which could facilitate the use of vitamin D treatment to enhance the pregnancy outcome of RPL. Collectively, it was suggested that vitamin D may be used as an important and effective immunotherapeutic agent for patients with RPL.

Created by admin. Last Modification: Wednesday March 31, 2021 13:34:05 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
15313 RPL chart.jpg admin 25 Mar, 2021 02:27 119.04 Kb 295
15312 RPL 6.jpg admin 25 Mar, 2021 02:27 44.69 Kb 218
15311 Recurrent pregnancy loss review.pdf PDF 2021 admin 25 Mar, 2021 02:24 636.48 Kb 290