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Pregnancy helped by single dose of 60,000 IU of Vitamin D – RCT March 2015

Supplementation of vitamin D in pregnancy and its correlation with feto-maternal outcome.

Clin Endocrinol (Oxf). 2015 Feb 14. doi: 10.1111/cen.12751. [Epub ahead of print]
Sablok A1 aanchalsablok54 at gmail.com, Batra A, Thariani K, Batra A, Bharti R, Aggarwal AR, Kabi BC, Chellani H.
1Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

VitaminDWiki Summary
(A) 60,000 IU
Vitamin D (B)
Women 60120
Vitamin D Level mother 18 ng 32 ng
Cord blood level 17 ng 23 ng
Birthweight 2,4 kg2.6 kg
preterm labour
or pre-eclampsia
or gestational diabetes.
44% 22%

CONTEXT: Vitamin D deficiency is widely prevalent throughout the world. Pregnant women, neonates and infants form most vulnerable groups for vitamin D deficiency.

OBJECTIVE: (1) To find prevalence of vitamin D deficiency in pregnant women. (2) To evaluate the effect of supplementation with cholecalciferol in improving vitamin D levels in pregnant women and evaluate its correlation with feto-maternal outcome.

DESIGN: Randomized control trial from years 2010 to 2012.

SETTING: Tertiary care centre, Delhi, India.

PARTICIPANTS: One-hundred and eighty pregnant women. Study population divided randomly into two groups: group A: nonintervention (60 women) and group B: intervention (120 women).

INTERVENTION: The intervention group received supplementation of vitamin D in dosages depending upon 25(OH)-D levels.

MAIN OUTCOME MEASURES: Risk of maternal complications such as preterm labour, pre-eclampsia and gestational diabetes associated with vitamin D deficiency and risk of low birthweight and poor Apgar score in infants of mothers with vitamin D deficiency.

RESULTS: Adjusted serum 25(OH)-D concentration was lower in group A as compared to group B (mean 46·11 ± 74·21 nmol/l vs 80 ± 51·53 nmol/l). Forty-four percent patients in group A and 20·3% patients in group B developed preterm labour/pre-eclampsia/gestational diabetes. Newborns of mothers in group A had lower cord blood levels of 25(OH)-D levels as compared to group B (mean 43·11 ± 81·32 nmol/l vs 56·8 ± 47·52 nmol/l). They also had lower birthweight of mean 2·4 ± 0·38 kg as compared to group B 2·6 ± 0·33 kg.

CONCLUSIONS: Vitamin D supplementation reduces risk of maternal comorbidities and helps improve neonatal outcomes.

PMID 25683660

Publisher rents PDF for $6 Perhaps no charge to patients and/or caregivers

RCT: Are vitamin D levels associated with pregnancy outcomes? Report on study at Vitamin D Council
Given large doses of vitamin D ( not daily) depending on deficiency level
  Sufficient (> 20 ng) 60,000 IU vitamin D at 20 weeks - not much left after 19 weeks!!
  Insufficient: 120,000 IU at 20 and 24 weeks
  Deficient:120,000 IU of vitamin D at 20, 24, 28, and 32 weeks.(about only half had > 20 ng at birth)

Vitamin DNone
Complications 20%44%
Small for gestational age8% 19%
Pre-eclampsia11% 21% (p = 0.08).

See also VitaminDWiki

The articles in Pregnancy AND Intervention are here:

IU Cumulative Benefit Blood level CofactorsCalcium $*/month
200 Better bones for mom
with 600 mg of Calcium
6 ng/ml increase Not needed No effect $0.10
400 Less Rickets (but not zero with 400 IU)
3X less adolescent Schizophrenia
Fewer child seizures
20-30 ng/ml Not needed No effect $0.20
2000 2X More likely to get pregnant naturally/IVF
2X Fewer dental problems with pregnancy
8X less diabetes
4X fewer C-sections (>37 ng)
4X less preeclampsia (40 ng vs 10 ng)
5X less child asthma
2X fewer language problems age 5
42 ng/ml Desirable < 750 mg $1
4000 2X fewer pregnancy complications
2X fewer pre-term births
49 ng/ml Should have
< 750 mg $3
6000 Probable: larger benefits for above items
Just enough D for breastfed infant
More maternal and infant weight
Should have
< 750 mg $4