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Resulting childhood Asthma cut in half if 4,400 IU Vitamin D (5 ways to improve it) - RCT April 2023

Baseline 25(OH)D, timing of supplementation initiation and prenatal vitamin D supplementation efficacy to prevent offspring asthma or recurrent wheeze

Am J Clin Nutr. 2023 Apr 17;S0002-9165(23)46848-7. doi: 10.1016/j.ajcnut.2023.04.019  PDF costs $31
Iskander L C Shadid 1, Nicklas Brustad 2, Mengdi Lu 3, Bo L Chawes 2, Hans Bisgaard 2, Robert S Zeiger 4, George T O'Connor 5, Leonard B Bacharier 6, Henk-Jan Guchelaar 7, Augusto A Litonjua 8, Scott T Weiss 3, Hooman Mirzakhani 9

Background: Prenatal vitamin D deficiency is associated with asthma or recurrent wheeze in offspring. However, evidence from randomized trials on the efficacy of vitamin D supplementation is inconclusive.

Objective: To examine the differential efficacy of prenatal vitamin D supplementation based on maternal baseline vitamin D status and starting time of supplementation to prevent early life asthma or recurrent wheeze.

Method: We conducted a secondary analysis of the Vitamin D Antenatal Asthma Reduction Trial (VDAART), a randomized double-blind trial of prenatal vitamin D supplementation initiated at 10-18 weeks of gestation (intervention 4400IU/daily vs placebo 400IU/daily) to prevent offspring asthma or recurrent wheeze by age of 6 years. We assessed the effect modification of supplementation by maternal baseline vitamin D status at enrollment and timing of initiation of supplementation.

Results: An inverse relationship was observed between maternal 25(OH)D levels at trial entry and 25(OH)D levels during late pregnancy (32-38 weeks of gestation) in both supplementation arms (p<0.001). Overall, supplementation efficacy was not dependent on maternal baseline 25(OH)D status. However, a trend towards the reduction of asthma or recurrent wheeze was observed across baseline groups in the intervention arm (p=0.01) with the greatest reduction in the most severely vitamin D deficient women (25(OH)D<12 ng/ml, aOR=0.48, CI=0.17-1.34). Gestational age at trial enrollment modified supplementation efficacy, showing a greater reduction of offspring asthma or recurrent wheeze with earlier intervention during pregnancy (aOR=0.85, CI=0.76-0.95), particularly in women at 9-12 weeks pregnant (aOR=0.45, CI=0.24-0.82).

Conclusion: Pregnant women with severe vitamin D deficiency show the greatest 25(OH)D improvement due to the supplementation. In these women, a dose of 4400 IU vitamin D might have a protective effect on early life offspring asthma or recurrent wheeze. Gestational age is suggested to modify the efficacy of prenatal vitamin D supplementation, showing the highest beneficial effect if supplementation is started during the first trimester of pregnancy.

5 ways to reduce asthma risk even more:

  1. Higher dose
  2. Start before 9th week
  3. Use a loading dose
  4. Use weekly dosing in place of daily
  5. Also use Vitamin D Receptor Activator

Brain development needs vitamin D level to have plateaued by 9th week

Fetal Development

See also VitaminDWiki

15+ Intervention pages with ASTHMA in title

This list is automatically updated

Items found: 15
Title Modified
Resulting childhood Asthma cut in half if 4,400 IU Vitamin D (5 ways to improve it) - RCT April 2023 20 Apr, 2023
Asthma and COPD in a few seniors greatly decreased by monthly 100,000 IU Vitamin D – RCT Feb 2021 28 Jun, 2021
Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017 25 Jul, 2020
Those with Asthma or COPD had half the response to Vitamin D – March 2020 19 Mar, 2020
Risk of infant Asthma cut in half if mother supplemented Vitamin D to get more than 30 ng – RCT Oct 2017 12 Mar, 2019
Vitamin D every 14 weeks is not often enough (asthma in this case)– Feb 2019 21 Feb, 2019
All asthma problems reduced after 1 year of Vitamin D – Nov 2017 10 Jul, 2018
Asthma treated by daily 50,000 IU of Vitamin D – April 2018 24 Jun, 2018
Asthma attacks reduced in half if Vitamin D level higher than 42 nanograms – RCT May 2014 18 Jul, 2017
Reduction of infant asthma may require good vitamin D when lung development starts (4 weeks) – March 2017 02 May, 2017
Asthma reduced 60 percent with vitamin D supplementation – meta-analysis 2014, 2015 15 Jan, 2017
Childhood asthma still reduced 4 months after 800 IU of Vitamin D daily - RCT Feb 2016 03 Aug, 2016
Asthma exacerbations with colds reduced by 40 percent with vitamin D supplementation – Nov 2015 25 Nov, 2015
Bronchial Asthma reduced with 60,000 IU monthly vitamin D – RCT Nov 2013 14 Sep, 2014
Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014 03 Aug, 2014