The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis
Nutrients 2018, 10(10), 1395; https://doi.org/10.3390/nu10101395 (registering DOI)
Qi Gao 1, Tingyan Kou 1, Bin Zhuang 2, Yangyang Ren 1, Xue Dong 1 and Qiuzhen Wang 1,*firstname.lastname@example.org
1 Department of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China
2 Department of the medical college of Qingdao University, Qingdao 266021, China
Sleep category starts with
Sleep Apnea 253 items as of Oct 2018
Search VitaminDWiki for (sleep OR insomnia) Magnesium 234 items as of Oct 2018
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Sleep disorders and Autism, TB, etc. (all have low vitamin D) – March 2018
- Sleep Problems in Pregnancy Tied to Premature Births (no surprise, both related to low vitamin D) – Aug 2017
- Vitamin D improves sleep and reduces pain – review of studies July 2017
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis Dec 2017
Sleep is aided by Vitamin D + Vitamin Bs
Sleep is also aided by Omega-3
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Omega-3 greatly reduced sleep deprivation problems in rats – June 2018
- Obstructive Sleep Apnea reduced by Omega-3 – June 2016
Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included.
By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of s
- sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72).
Subgroup analysis showed that VDD also was associated with
- poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05),
- short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and
- sleepiness (OR: 1.36, 95% CI: 1.12, 1.65).
Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep.
This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.