The Association between Vitamin D Deficiency and Sleep Disorders: A Systematic Review and Meta-Analysis
Nutrients 2018, 10(10), 1395; https://doi.org/10.3390/nu10101395 (registering DOI)
Qi Gao 1, Tingyan Kou 1, Bin Zhuang 2, Yangyang Ren 1, Xue Dong 1 and Qiuzhen Wang 1,*firstname.lastname@example.org
1 Department of the College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao 266021, China
2 Department of the medical college of Qingdao University, Qingdao 266021, China
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – Feb 2019 identical conclusion
- Poor sleep if low Vitamin D, Magnesium, or Vitamin B6 (NHANES) – June 2019
Sleep category starts with
Sleep Apnea 253 items as of Oct 2018
Search VitaminDWiki for (sleep OR insomnia) Magnesium 228 items as of June 2019
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Sleep disorders and Autism, TB, etc. (all have low vitamin D) – March 2018
- Sleep Problems in Pregnancy Tied to Premature Births (no surprise, both related to low vitamin D) – Aug 2017
- Vitamin D improves sleep and reduces pain – review of studies July 2017
- Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis Dec 2017
Sleep is aided by Vitamin D + Vitamin Bs
Items in both categories Sleep and Omega-3 are listed here:
- Omega-3 greatly reduced sleep deprivation problems in rats – June 2018
- Happy Nurses Project gave Omega-3 for 3 months – reduced depression, insomnia, anxiety, etc for a year – RCT July 2018
- Obstructive Sleep Apnea reduced by Omega-3 – June 2016
- Longer time to fall to sleep in winter unless eat salmon (vitamin D and Omega-3) – May 2014
Epidemiology studies have investigated the association between vitamin D and the risk of sleep disorders, but the results remain controversial. Therefore, we conducted this meta-analysis with the goal of clarifying the association between vitamin D and sleep disorders risk. All relevant studies were searched using PubMed, EMBASE, and Web of Science from inception to January 2018. Pooled odds ratios (ORs) and 95% confidence interval (CIs) were calculated using a fixed-effect model A total of nine studies (6 cross-sectional, 2 case-control, and 1 cohort studies) involving 9397 participants were included.
By comparing the lowest verse highest levels of serum vitamin D, we found that participants with vitamin D deficiency (VDD) had a significantly increased risk of s
- sleep disorders (OR: 1.50, 95% CI: 1.31, 1.72).
Subgroup analysis showed that VDD also was associated with
- poor sleep quality (OR: 1.59, 95% CI: 1.23, 2.05),
- short sleep duration (OR: 1.74, 95% CI: 1.30, 2.32), and
- sleepiness (OR: 1.36, 95% CI: 1.12, 1.65).
Subgroup analyses further indicated that serum 25(OH)D <20 ng/mL could significantly increase the risk of unhealthy sleep.
This meta-analysis suggest that vitamin D deficiency is associated with a higher risk of sleep disorders. More high-quality cohort studies and randomized controlled trials (RCTs) are needed to verify this association.