Serum Vitamin D Is Significantly Inversely Associated with Disease Severity in Caucasian Adults with Obstructive Sleep Apnea Syndrome.
Sleep. 2016 Feb 1;39(2):293-300. doi: 10.5665/sleep.5430.
Kerley CP1,2, Hutchinson K3,4, Bolger K1, McGowan A1, Faul J1, Cormican L1.
1Respiratory and Sleep Diagnostics Department, Connolly Hospital, Blanchardstown, Dublin, Ireland.
2School of Medicine and Medical Sciences, University College Dublin, Belfield, Dublin, Ireland.
3Biomnis Ireland, Dublin, Ireland.
4NCBES, National University of Ireland, Galway, Ireland.
To evaluate vitamin D (25(OH)D) levels in obstructive sleep apnea syndrome (OSAS) and possible relationships to OSAS severity, sleepiness, lung function, nocturnal heart rate (HR), and body composition. We also aimed to compare the 25(OH)D status of a subset of OSAS patients compared to controls matched for important determinants of both OSAS and vitamin D deficiency (VDD).
This was a cross-sectional study conducted at an urban, clinical sleep medicine outpatient center. We recruited newly diagnosed, Caucasian adults who had recently undergone nocturnal polysomnography. We compared body mass index (BMI), body composition (bioelectrical impedance analysis), neck circumference, sleepiness (Epworth Sleepiness Scale), lung function, and vitamin D status (serum 25-hydrpoxyvitamin D (25(OH)D) across OSAS severity categories and non-OSAS subjects. Next, using a case-control design, we compared measures of serum 25(OH)D from OSAS cases to non-OSAS controls who were matched for age, gender, skin pigmentation, sleepiness, season, and BMI.
106 adults (77 male; median age = 54.5; median BMI = 34.3 kg/m(2)) resident in Dublin, Ireland (latitude 53°N) were recruited and categorized as non-OSAS or mild/moderate/severe OSAS. 98% of OSAS cases had insufficient 25(OH)D (< 75 nmol/L),
including 72% with VDD (< 50 nmol/L). 25(OH)D levels decreased with OSAS severity (P = 0.003). 25(OH)D was inversely correlated with BMI, percent body fat, AHI, and nocturnal HR. Subsequent multivariate regression analysis revealed that 25(OH)D was independently associated with both AHI (P = 0.016) and nocturnal HR (P = 0.0419). Our separate case-control study revealed that 25(OH)D was significantly lower in OSAS cases than matched, non-OSAS subjects (P = 0.001).
We observed widespread vitamin D deficiency and insufficiency in a Caucasian, OSAS population. There were significant, independent, inverse relationships between 25(OH)D and AHI as well as nocturnal HR, a known cardiovascular risk factor. Further, 25(OH)D was significantly lower in OSAS cases compared to matched, non-OSAS subjects. We provide evidence that 25(OH)D and OSAS are related, but the role, if any, of replenishment has not been investigated.
© 2016 Associated Professional Sleep Societies, LLC.
"Obstructive Sleep Apnea" strongly associated with COPD
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
- COPD reduced by vitamin D taken once every 60 days – RCT Dec 2014
- COPD Overview
- The worse the sleep apnea, the lower the vitamin D levels – meta-analysis 2017, 2020
- Many sleep disorders cured with vitamin D levels of 60 to 80 nanograms – May 2012
- The Better Sleep Vitamin (Vitamin D) – nice 3 dollar book Feb 2015
- Poor sleep if low Vitamin D, Magnesium, or Vitamin B6 (NHANES) – June 2019
- Sleep category listing has
70 items along with related searches
Sleep Apnea patients – 98 percent had low vitamin D – Feb 2016
- CPAP increased Vitamin D levels in males April 2014 free PDF is online
- Adults 45% more likely to have Sleep Apnea if low vitamin D Feb 2016
Publisher wants $20 for the PDF
3010 visitors, last modified 22 Jun, 2019,