Cross-sectional and Prospective Associations of Actigraphy-Assessed Sleep Regularity With Metabolic Abnormalities: The Multi-Ethnic Study of Atherosclerosis
Diabetes Care 2019 May; https://doi.org/10.2337/dc19-0596
Tianyi Huang, Susan Redline
This study found associations
Possible relationships include
- Low Vitamin D ==> Poor Sleep ==> Metabolic problems
- Poor Sleep ==> Low Vitamin D ==> Metabolic Problems
But, more important, Add Vitamin D ==> improves sleep AND Add Vitamin D ==> Reduces Metabolic problems
Items in both categories Metabolic Syndrome and Intervention:
- Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
- Waist size reduced 3 cm by Vitamin D in those with Metabolic Syndrome – Jan 2017
- Metabolic Syndrome risk reduced 44 percent when vitamin D levels increased by 30 nanograms – Aug 2015
- Diabetic hypertension reduced with Vitamin D and Calcium – RCT March 2015
- 5700 IU vitamin D improved various growth factors in overweight people – Oct 2012
Items in both categories Sleep and Intervention:
- Sleeps disorders nicely treated by Vitamin D (50,000 IU bi-weekly) – RCT May 2017
- Restless Legs Syndrome dramatically reduced by vitamin D, etc
- Sleep disorders cured by 60-80 ng of vitamin D and some B vitamins – March 2013
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
See other studies in VitaminDWiki
- Vitamin D deficiency increases risk of Metabolic Syndrome – 1998
- Metabolic Syndrome risk increases about 70 percent if poor Vitamin D Receptor
- Poor sleep 1.5 X more likely if less than 20 ng of Vitamin D – meta-analysis Oct 2018
- Shift workers have low vitamin D, poorer sleep, and are more depressed – March 2019
- Sleep may be regulated by Vitamin D via two pathways – Nov 2018
OBJECTIVE To cross-sectionally and prospectively investigate the association between irregular sleep patterns, a potential marker for circadian disruption, and metabolic abnormalities.
RESEARCH DESIGN AND METHODS In the Multi-Ethnic Study of Atherosclerosis, participants completed 7-day actigraphy at exam 5 (2010–2013) and were prospectively followed throughout exam 6 (2016 to 2017). Sleep regularity was quantified by the 7-day SD of actigraphy-assessed sleep duration and sleep onset timing. Metabolic abnormalities were defined by 1) the National Cholesterol Education Program Adult Treatment Panel III criteria and 2) a data-driven clustering of metabolic factors.
RESULTS In the exam 5 cross-sectional analysis adjusted for sociodemographic and lifestyle factors (n = 2,003), every 1-h increase in the sleep duration SD was associated with 27% (95% CI 1.10, 1.47) higher odds of metabolic syndrome, and every 1-h increase in the sleep timing SD was associated with 23% (95% CI 1.06, 1.42) higher odds. The associations remained significant, with additional adjustment for sleep-related factors including sleep duration. In the prospective analysis (n = 970), the corresponding fully adjusted odds ratio (OR) (95% CI) was 1.27 (0.97, 1.65) for sleep duration and 1.36 (1.03, 1.80) for sleep timing. Compared with the cluster of few metabolic changes, every 1-h increase in sleep variability was associated with almost doubled odds for the cluster characterized by incidence of
- multiple metabolic abnormalities (OR 1.97 [95% CI 1.18, 3.30] for sleep duration and
- OR 2.10 [95% CI 1.25, 3.53] for sleep timing).
CONCLUSIONS Increased variability in sleep duration and timing was associated with higher prevalence and incidence of metabolic abnormalities even after considering sleep duration and other lifestyle factors.