25-hydroxy vitamin D level is associated with total MRI burden of cerebral small vessel disease in ischemic stroke patients.
Int J Neurosci. 2018 Jul 21:1-24. doi: 10.1080/00207454.2018.1503182. [Epub ahead of print]
Feng C1, Tang N1, Huang H2, Zhang G3, Qi X3, Shi F3.
|Increased Risk if low vitamin D|
|Severe white matter lesions||3.3 X|
|Severe enlarged perivascular spaces||2.4 X|
|Increasing total cerebral small vessel disease||3.0 X|
Strokes are both PREVENTED and TREATED with Vitamin D
- Cognitive impairment after stroke increased if Vitamin D deficient - Dec 2018
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018
- Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
- Ischemic Stroke risk reduced by 2.5 if have good level of vitamin D – meta-analysis Feb 2018
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
- Low vitamin D at time of stroke predicts 3 X more likely to die in a month (unless add Vit D) – Dec 2017
PDF is available free at Sci-Hub 10.1080/00207454.2018.1503182
Decreased 25-hydroxyvitamin D [25(OH)D] has been reported to be related to increased risk of cerebrovascular disease. We aimed to investigate whether an association exists between 25(OH)D levels and cerebral small vessel disease (cSVD).
Patients with first-ever minor ischemic stroke or transient ischemic attack were recruited prospectively during Jan 2017 to Dec 2017. Serum 25(OH)D levels were measured at admission in all patients. Magnetic resonance imaging (MRI) was performed to determine the presence of cSVD, including silent lacunar infarcts (SLIs), white matter lesions (WMLs), cerebral microbleeds (CMBs), and enlarged perivascular spaces (EPVs). The severity of cSVD was evaluated by total MRI cSVD burden, an ordinal score from 0 to 4. The association between the baseline 25(OH)D level and cSVD was analyzed by multiple logistic regression models.
Of 234 patients included, the median 25(OH)D level was 39.2 nmol/L. The proportions of patients with 0 to 4 cSVD features were 8.5%, 29.1%, 42.3%, 16.2%, and 3.8%, respectively. After adjusting for potential confounders, multiple logistic regression analysis demonstrated that patients with 25(OH)D level in its first quartile, compared with those in its fourth quartile, were more likely to have severe WMLs [odds ratio (OR), 3.31; 95% confidence interval (CI) 1.74-9.67; P = 0.004], severe EPVs (OR, 2.35; 95% CI 1.11-6.02, P = 0.046] and increasing total MRI cSVD burden (OR, 3.00; 95% CI 1.36-6.53, P = 0.006).
Lower levels of 25(OH)D is associated with greater total MRI cSVD burden in ischemic stroke patients.