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Vitamin D and COVID-19 both affect immune cells – June 2021

Shedding light on vitamin D: the shared mechanistic and pathophysiological role between hypovitaminosis D and COVID-19 risk factors and complications

Inflammopharmacology (2021) https://doi.org/10.1007/s10787-021-00835-6
Esraa Menshawey, Rahma Menshawey & Omnia Azmy Nabeh
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Severe acute respiratory syndrome coronavirus (SARS-COV-2) is the culprit of the Coronavirus Disease (COVID-19), which has infected approximately 173 million people and killed more than 3.73 million. At risk groups including diabetic and obese patients are more vulnerable to COVID-19-related complications and poor outcomes. Substantial evidence points to hypovitaminosis D as a risk factor for severe disease, the need for ICU, and mortality. 1,25(OH)D, a key regulator of calcium homeostasis, is believed to have various immune-regulatory roles including; promoting anti-inflammatory cytokines, down regulating pro-inflammatory cytokines, dampening entry and replication of SARS-COV-2, and the production of antimicrobial peptides. In addition, there are strong connections which suggest that dysregulated 1,25(OH)D levels play a mechanistic and pathophysiologic role in several disease processes that are shared with COVID-19 including: diabetes, obesity, acute respiratory distress syndrome (ARDS), cytokine storm, and even hypercoagulable states. With evidence continuing to grow for the case that low vitamin D status is a risk factor for COVID-19 disease and poor outcomes, there is a need now to address the public health efforts set in place to minimize infection, such as lock down orders, which may have inadvertently increased hypovitaminosis D in the general population and those already at risk (elderly, obese, and disabled). Moreover, there is a need to address the implications of this evidence and how we may apply the use of cheaply available supplementation, which has yet to overcome the near global concern of hypovitaminosis D. In our review, we exhaustively scope these shared pathophysiologic connections between COVID-19 and hypovitaminosis D.


Created by admin. Last Modification: Tuesday June 29, 2021 15:01:13 GMT-0000 by admin. (Version 4)

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15835 Immune Cell Response.jpg admin 29 Jun, 2021 14:25 121.97 Kb 52
15834 ToC shedding light.jpg admin 29 Jun, 2021 14:24 40.18 Kb 55
15833 Shedding light on vitamin D and COVID-19.pdf PDF - 2021 admin 29 Jun, 2021 14:23 1.29 Mb 15
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