The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?
International Journal of General Medicine 2021:14 3849-3870
Rbab Taha ©'. Shahd Abureesh ©. Shuruq Alghamdi 2 Rola Y Hassan Mohamed M Cheikh 4,5 Rania A Bagabir6 Hani Almoallim©2’7 Altaf Abdulkhaliq 8 'Department of Transplant Infectious Disease, University Health Network, Toronto, Ontario, Canada; 2Department of Medicine, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 3Department of Internal Medicine, King Fahad Armed Forces Hospital, Jeddah, Saudi Arabia; 4Department of Internal Medicine, Doctor Soliman Fakeeh Hospital, Jeddah, Saudi Arabia; 5Department of Medicine, Fakeeh College for Medical Sciences, Jeddah, Saudi Arabia; 6Department of Immunology and Hematology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 7Alzaidi Chair of Research in Rheumatic Diseases, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 8Department of Clinical Biochemistry, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia
Table of Contents
Immune systems helped by 50,000 IU of vitamin D (weekly for 3 months) – May 2021
Most, but not all, responded well to the intervention
Starting with a loading dose of 50,000 IU daily for a week or 350,000 IU in a single day would have reduced the time from 3 months to <2 weeks
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Elderly Vitamin D Loading Dose of 500,000 IU is safe and effective – RCT 2009
- Vitamin D loading dose (stoss therapy) proven to improve health
Immunity category starts with:
see also
Virus category listing hasOverview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021 nothing about Vitamin D
13 titles in VitaminDWiki contained INNATE or ADAPTIVE as of July 2021
Increasing publications on vitamin D and Infection
COVID-19 treated by Vitamin D - studies, reports, videos
- As of Nov 25, 2022, the VitaminDWiki COVID page had: 19 trial results, 37 meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, 26 risk factors are ALL associated with low Vit D, Recent Virus pages Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 116 COVID Clinical Trials using Vitamin D (08/2022)
5 most-recently changed Virus entries
Items in BOTH categories Immunity and Virus:
- A year after 2nd COVID vaccination, stems cells not available to fetus immune system – Nov 2022
- Vitamin D, immune System, Infection, and COVID- Video Oct 2022
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- Long-Haul more prevalent among seniors - June - 2022
- Vitamin D, Immune function, and SARS-CoV2 – May 2022
- Innate immune suppression by SARS-CoV-2 mRNA vaccinations - April 2022
- Immune system both activates and uses vitamin D (in brain, fight COVID, etc.) - March 2022
- COVID can be fought by healthy immune systems (vitamins, etc.) - Feb 2022
- Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
- Vaccine definition by the CDC seems to now include Vitamin D - Sept 2021
- Immune system - great 11-minute animated video - Aug 2021
- Vitamin D for infections and COVID (50,000 IU weekly for 3 months) – July 2021
- Vitamin D and COVID-19 both affect immune cells – June 2021
- T-cells need at least 40-50 ng of Vitamin D to fight COVID-19 - June 2021
- COVID-19 activates and Vitamin D de-activates 12 cytokines (mini-review)– May 2021
- Long-haul COVID-19 - another hint that Vitamin D should help - Dec 2020
- Strong innate immune systems do not get viral symptoms (COVID-19) – April 2021
- How healthy innate immune systems adapt to viral mutations - Feb 2021
- immune system charts (vitamin D, virus, mutation, etc)
- 600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
- Ways to boost immune system to fight COVID-19 (no protocol) - Oct 2020
- COVID-19 patients with low vitamin D had far fewer natural killer cells – Dec 2020
- Protect your immune system from COVID-19, flu, colds, etc with 10,000 IU of vitamin D etc. - Nov 2020
- 19X fewer COVID-19 infections if innate immune system activated – trial Oct 21, 2020
- Nutrients etc, which fight viruses and fortify the immune system
- Covid-19, T cells, and Vitamin D
- Mild COVID-19 quickly treated by Zinc lozenges in 4 people – June 6, 2020
- Clear Association between Influenza and low Vitamin D - March 2020
- Immune system is capable of producing 1 Quadrillion unique antibodies - Jan 2019
- Immune system is fortified by micronutrients such as vitamin D – Review Jan 2020
- Vitamin D probably can both prevent Influenza and augment vaccine effectiveness – Aug 2018
- Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
- Immunity increased by Vitamin D via cells and genes (HIV etc.) – March 2018
- Flu
- Congenital Zika Syndrome (more than microcephaly) – Spring 2016
- Dengue fever immune response and micronutrients (vitamins D, E, A, and Zinc, Iron, Chromium) – Nov 2015
- Adaptive immunity (cancer, viruses, autoimmune) and vitamin D – April 2016
- Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009
- Immune response to respiratory viruses – vitamin D connection – review May 2015
- Vitamin D may protect against Ebola
- Malaria in mice brains, and associated inflammation, prevented by Vitamin D intervention – July 2014
- Vitamin D Deficiency May Help Spread of Hepatitis B Throughout Liver – May 2013
- 10X reactions to flu vaccine when vitamin D deficient
50,000 IU weekly helped >18 health problems
VitaminDWiki pages containing "50,000" in title 163 as of Dec 2021
Download the PDF from VitaminDWiki
Vitamin D is proposed to have a potential role in the pathogenicity, clinical presentation, prognosis, complications, and treatment of several diseases. In addition to its well-known role in calcium metabolism, vitamin D regulates both innate and adaptive immunity, and subsequently modulates the antiviral and antibacterial inflammatory immune responses. In view of the emerging coronavirus disease 2019 (COVID-19) pandemic, searching for potential therapeutic and protective strategies is of urgent interest, and vitamin D is one of the promising agents in this field. In this review, we present data from literature that supports the promising role of vitamin D in treatment and/or prevention of several infections including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
This review summarizes vitamin D metabolism and its role in inflammation, thrombosis and immune regulation. It also reviews, in short, the role of vitamin D and the impact of its deficiency in several infections namely tuberculosis, influenza, human immunodeficiency virus (HIV), and SARS-CoV-2. Considering the roles of vitamin D on immune modulation, controlling of thrombosis, and attacking several microorganisms, the current review will elaborate on the association between these salient roles of vitamin D and the pathogenicity of various infectious agents including COVID-19. Consequently, the comprehensive finding of the current review shows a possible significant impact of vitamin D supplement as a hope in preventing, treating, and/or improving the progression of certain infections, specifically during the worldwide attempts to fight against the COVID-19 pandemic and minimize the severity of health complications encountered accordingly. In addition, avoiding a status of vitamin D deficiency to obtain its positive effects on the immune system and its protective mechanism during infections will be a general benefit overall.
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