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When over 50, poor health is associated with poor vitamin D– review Oct 2019

Vitamin D as a Biomarker of Ill Health among the Over-50s: A Systematic Review of Cohort Studies

Nutrients 2019, 11(10), 2384; https://doi.org/10.3390/nu11102384
Silvia Caristia 1,Nicoletta Filigheddu 1,Francesco Barone-Adesi 1,Andrea Sarro 1,Tommaso Testa 1,Corrado Magnani 1,Gianluca Aimaretti 1,Fabrizio Faggiano 1,2 andPaolo Marzullo 1,3,*
1 Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy
2 Epidemiology Centre of Local Health Unit of Vercelli, 12100 Vercelli, Italy
3 I.R.C.C.S. Istituto Auxologico Italiano, Piancavallo, 28921 Verbania, Italy
(This article belongs to the Special Issue Vitamin D and Obesity)


Elderly Vitamin D Loading Dose of 500,000 IU is safe and effective – RCT 2009

13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following

  1. Senior skin produces 4X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptor genes as they age
    Receptors are needed to get Vitamin D in blood actually into the cells
  3. Many other Vitamin D genes decrease with age
  4. Since many gene activations are not detected by a blood test,
    more Vitamin D is often needed, especially by seniors
  5. Seniors are indoors more than when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
  6. Seniors wear more clothing outdoors than when younger
    Seniors also are told to fear skin cancer & wrinkles
  7. Seniors often take various drugs which end up reducing vitamin D
    Some reductions are not detected by a vitamin D test of the blood
    statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  8. Seniors often have one or more diseases that consume vitamin D
    osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
  9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
  10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
  12. Vitamin D is not as bioavailable in senior intestines
  13. Seniors with poorly functioning kidneys do not process vitamin D as well
  14. Glutathione (which increases Vitamin D getting to cells) decreases with age
       Seniors category has 431 items

 Download the PDF from VitaminDWiki

Table 1 Associations explored


High quality studies (10 = highest)


Outcome is associated with Low Vitamin D = negative association


Background: The association between circulating levels of vitamin D and the incidence of chronic diseases is known. The identification of vitamin D as a biomarker of physiological/pathological ageing could contribute to expanding current knowledge of its involvement in healthy ageing.

Methods: According to PRISMA guidelines, a systematic review was conducted on cohorts studying the role of 25OH-Vitamin D [25(OH)D] and 1,25(OH)2-Vitamin D [1,25(OH)2D] concentrations as biomarkers of healthy ageing. We consulted MedLine, Scopus, and Web of Science to search for studies on the association between vitamin D status in populations of originally healthy adults, and outcomes of longevity, illness, and physical and cognitive functionality. The quality of the studies was assessed using the Newcastle Ottawa scale.

Results: Twenty cohorts from 24 articles were selected for this review. Inverse associations were found between low 25(OH)D levels and all-cause mortality, respiratory and cardiovascular events, as well as markers relating to hip and non-vertebral fractures. Associations between 1,25(OH)2D and healthy ageing outcomes gave similar results, although of lower clinical significance.

Conclusions: This systematic review pinpoints peculiar aspects of vitamin D as a multidimensional predictor of ill health in the ageing process. Further well-designed controlled trials to investigate whether vitamin D supplement results in superior outcomes are warranted in the future

Clipped from PDF

  • “The primary outcomes of the included studies were mainly related to disease incidence (87%), all-cause mortality (9%), cognitive and physical functionality (1.8% for both). We did not find any analyses on the other six dimensions of healthy ageing concept (Table 1).”


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