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When over 50, poor health is associated with poor vitamin D– review Oct 2019

Vitamin D as a Biomarker of Ill Health among the Over-50s: A Systematic Review of Cohort Studies

Nutrients 2019, 11(10), 2384; https://doi.org/10.3390/nu11102384
Silvia Caristia 1,Nicoletta Filigheddu 1,Francesco Barone-Adesi 1,Andrea Sarro 1,Tommaso Testa 1,Corrado Magnani 1,Gianluca Aimaretti 1,Fabrizio Faggiano 1,2 andPaolo Marzullo 1,3,*
1 Department of Translational Medicine, Università del Piemonte Orientale, 28100 Novara, Italy
2 Epidemiology Centre of Local Health Unit of Vercelli, 12100 Vercelli, Italy
3 I.R.C.C.S. Istituto Auxologico Italiano, Piancavallo, 28921 Verbania, Italy
(This article belongs to the Special Issue Vitamin D and Obesity)

VitaminDWiki

10 reasons why seniors need more vitamin D has the following

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
    (The effect of low Vitamin D receptor genes does not show up on vitamin D test results)
  3. Seniors are indoors more than when when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery
  5. Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  6. Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Seniors not have as much Magnesium needed to use vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)

 Download the PDF from VitaminDWiki

Table 1 Associations explored

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High quality studies (10 = highest)

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Outcome is associated with Low Vitamin D = negative association

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Background: The association between circulating levels of vitamin D and the incidence of chronic diseases is known. The identification of vitamin D as a biomarker of physiological/pathological ageing could contribute to expanding current knowledge of its involvement in healthy ageing.

Methods: According to PRISMA guidelines, a systematic review was conducted on cohorts studying the role of 25OH-Vitamin D [25(OH)D] and 1,25(OH)2-Vitamin D [1,25(OH)2D] concentrations as biomarkers of healthy ageing. We consulted MedLine, Scopus, and Web of Science to search for studies on the association between vitamin D status in populations of originally healthy adults, and outcomes of longevity, illness, and physical and cognitive functionality. The quality of the studies was assessed using the Newcastle Ottawa scale.

Results: Twenty cohorts from 24 articles were selected for this review. Inverse associations were found between low 25(OH)D levels and all-cause mortality, respiratory and cardiovascular events, as well as markers relating to hip and non-vertebral fractures. Associations between 1,25(OH)2D and healthy ageing outcomes gave similar results, although of lower clinical significance.

Conclusions: This systematic review pinpoints peculiar aspects of vitamin D as a multidimensional predictor of ill health in the ageing process. Further well-designed controlled trials to investigate whether vitamin D supplement results in superior outcomes are warranted in the future

Clipped from PDF

  • “The primary outcomes of the included studies were mainly related to disease incidence (87%), all-cause mortality (9%), cognitive and physical functionality (1.8% for both). We did not find any analyses on the other six dimensions of healthy ageing concept (Table 1).”

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