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Many Infectious diseases (virus) treated and prevented by Vitamin D – review July 2009

Vitamin D for treatment and prevention of infectious diseases: a systematic review of randomized controlled trials.

Endocr Pract. 2009 Jul-Aug;15(5):438-49. doi: 10.4158/EP09101.ORR.
Yamshchikov AV1, Desai NS, Blumberg HM, Ziegler TR, Tangpricha V.
1Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30030, USA. AYAMSHC at emory.edu

335 studies reference this study as of Oct 2020

OBJECTIVE: To review the existing human controlled intervention studies of vitamin D as adjunctive therapy in settings of infection and provide recommendations for design and implementation of future studies in this field on the basis of the evidence reviewed.

METHODS: We conducted a systematic review of randomized controlled clinical trials that studied vitamin D for treatment or prevention of infectious diseases in humans. Studies from 1948 through 2009 were identified through search terms in PubMed and Ovid MEDLINE.

RESULTS: Thirteen published controlled trials were identified by our search criteria. Ten trials were placebo controlled, and 9 of the 10 were conducted in a rigorous double-blind design. The selected clinical trials demonstrated substantial heterogeneity in baseline patient demographics, sample size, and vitamin D intervention strategies. Serious adverse events attributable to vitamin D supplementation were rare across all studies. On the basis of studies reviewed to date, the strongest evidence supports further research into adjunctive vitamin D therapy for

  • tuberculosis,
  • influenza
  • viral upper respiratory tract illnesses.

In the selected studies, certain aspects of study design are highlighted to help guide future clinical research in the field.

CONCLUSION: More rigorously designed clinical trials are needed for further evaluation of the relationship between vitamin D status and the immune response to infection as well as for delineation of necessary changes in clinical practice and medical care of patients with vitamin D deficiency in infectious disease settings.

PMID: 19491064
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6588 2009 T3.jpg admin 24 Apr, 2016 96.66 Kb 1384
6587 2009 table 1.jpg admin 24 Apr, 2016 50.12 Kb 1321
6586 Vitamin D for treatment and prevention of infectious diseases - 2009.pdf admin 24 Apr, 2016 323.48 Kb 1101