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Vitamin D aids the clearing out of old cells (autophagy) – many studies


Vitamin D in Autophagy Signaling for Health and Diseases: – Aug 2021

Insights on Potential Mechanisms and Future Perspectives
J Nutr Biochem. 2021 Aug 14;108841. doi: 10.1016/j.jnutbio.2021.108841 PDF is behind a paywall
Sujit K Bhutia 1
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Vitamin D regulates the pleiotropic effect to maintain cellular homeostasis and epidemiological evidence establishes an association between vitamin D deficiency and various human diseases. Here, the role of autophagy, the cellular self-degradation process, in vitamin D-dependent function is documented in different cellular settings and discussed the molecular aspects for treating chronic inflammatory, infectious diseases, and cancer. Vitamin D activates autophagy through a genomic and non-genomic signaling pathway to influence a wide variety of physiological functions of different body organs along with bone health and calcium metabolism. Moreover, it induces autophagy as a protective mechanism to inhibit oxidative stress and apoptosis to regulate cell proliferation, differentiation, and immune modulation. Furthermore, vitamin D and its receptor regulate autophagy signaling to control inflammation and host immunity by activating antimicrobial defense mechanisms. Vitamin D has been revealed as a potent anticancer agent and induces autophagy to increase the response to radiation and chemotherapeutic drugs for potential cancer therapy. Increasing vitamin D levels in the human body through timely exposure to sunlight or vitamin D supplements could activate autophagy as part of the homeostasis mechanism to prevent multiple human diseases and aging-associated dysfunctions.

Table of Contents

2. Vitamin D, biosynthesis, and receptor
3. Autophagy: the self-degradative mechanism
4. Vitamin D, vitamin D receptor, and autophagy signaling
5. Vitamin D in health and diseases: the role of autophagy
5.1. Vitamin D-induced autophagy in maintaining cellular homeostasis
5.1.1. Skin and vitamin D: the complex relationship
5.1.2. Maintaining healthy bone, periodontal health, and muscle function
5.1.3. Heart and blood vessel abnormalities
5.1.4. Nervous system and neurological disorder
5.1.5. Gastrointestinal system and gut microbiome
5.1.6. Liver and inflammation
5.1.7. Pancreas, kidney, and diabetes pathogenesis
5.1.8. Lungs and pulmonary diseases
5.1.9. Ovary and gynecological disorder
5.2. Vitamin D-induced lethal autophagy controls cellular transformation and cancer
5.3. Vitamin D-induced autophagy in immunity and infection
5.4. Vitamin D, Autophagy, and aging: Does it have a role in controlling COVID-19?
6. Conclusion and future perspectives


Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection - 2020

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Enhance Autophagy with This ONE Vitamin!: Dr.Berg - 2 minute Video - May 2019

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See also VitaminDWiki

Autophagy occurs >500 times in VitaminDWiki - mainly in PDFs

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Vitamin D reduces COVID-19 complications – June 2021


Immunity category in VitaminDWiki

236 items in Immunity category

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Virus category listing has 1105 items along with related searches

Overview Influenza and vitamin D
Vitamin D helps both the innate and adaptive immune systems fight COVID-19 – Jan 2022
Vitamin D aids the clearing out of old cells (autophagy) – many studies
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020
Search for treg OR "t-cell" in VitaminDWiki 1440 items as of Jan 2020
141 VitaminDWiki pages contained "infection" in title (June 2021)
Search VitaminDWik for BACTERIA in title 25 items as of Aug 2019
Vitamin D and the Immune System – chapter Aug 2019
7X less risk of influenza if Vitamin D levels higher than 30 ng – Oct 2017
Common cold prevented and treated by Vitamin D, Vitamin C, Zinc, and Echinacea – review April 2018
Vitamin D improves T Cell immunity – RCT Feb 2016
Immune system - great 11-minute animated video - Aug 2021 nothing about Vitamin D
13 titles in VitaminDWiki contained INNATE or ADAPTIVE as of July 2021
Increasing publications on vitamin D and Infection
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40 studies are in both Immunity and Virus categories

Created by admin. Last Modification: Wednesday August 18, 2021 16:42:49 GMT-0000 by admin. (Version 11)

Attached files

ID Name Comment Uploaded Size Downloads
16094 Autophagy video.jpg admin 18 Aug, 2021 12:31 71.16 Kb 163
16093 Autophage 2020 F2.jpg admin 18 Aug, 2021 12:18 89.10 Kb 166
16092 Autophage 2020b.jpg admin 18 Aug, 2021 12:17 63.64 Kb 150
16091 Autophagy 2020a.jpg admin 18 Aug, 2021 12:17 70.04 Kb 204
16090 Autophagy 2020_compressed.pdf admin 18 Aug, 2021 12:17 740.12 Kb 155
16089 Autophagy and D.jpg admin 18 Aug, 2021 11:50 130.20 Kb 258
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