Vitamin D3 replacement enhances antigen-specific immunity in older adults
Emma S Chambers, Milica Vukmanovic-Stejic, Carolin T Turner, Barbara B Shih, Hugh Trahair, Immunotherapy Advances, ltaa008, https://doi.org/10.1093/immadv/ltaa008
Gabriele Pollara, Evdokia Tsaliki, Malcolm Rustin, Tom C Freeman, Neil A Mabbott, Mahdad Noursadeghi, Adrian R Martineau, Arne N Akbar
- This study used 6,400 IU of vitamin D daily for 14 weeks to restore the immune system enough to fight off the Zoster virus.
- Many studies have observed that Vitamin D fights the enveloped virus which causes COVID-19
- Risk of enveloped virus infection is increased 50 percent if poor Vitamin D Receptor - meta-analysis Dec 2018
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As of March 31, 2024, the VitaminDWiki COVID page had: trial results, meta-analyses and reviews, Mortality studies see related: Governments, HealthProblems, Hospitals, Dark Skins, All 26 COVID risk factors are associated with low Vit D, Fight COVID-19 with 50K Vit D weekly Vaccines Take lots of Vitamin D at first signs of COVID 166 COVID Clinical Trials using Vitamin D (Aug 2023) Prevent a COVID death: 9 dollars of Vitamin D or 900,000 dollars of vaccine - Aug 2023
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Note: 70% of the trials are using 100,000 IU of vitamin D in the first week
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Loading Dose of Vitamin D
= large total dose over 1 day to 60 days
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Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
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It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
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- Surgery complications cut in half by 300,000 IU of vitamin D 2 weeks before (hip and knee) – RCT May 2024
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- Single 600,000 IU dose of nanoemulsion Vitamin D is safe and effective to fight COVID, even if delay until enter ICU – RCT May 2024
- Vitamin D loading dose of 30,000 IU twice a week is safe and effective – RCT July 2023
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- Vitamin D is needed before many surgeries – many studies and RCTs
- 400,000 IU of vitamin D 3 days after COVID symptoms reduced 14 day mortality by 3X – Annweiler RCT May 2022
- High-dose Vitamin D safe for children (10,000 IU daily, 600,000 IU bolus) – meta-analysis April 2022
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- Rapid Vitamin D Delivery May Result in Better COVID Outcomes - Dec 9, 2021
- Vitamin D loading doses quickly and safely raise levels – meta-analysis Dec 2021
- Childhood cancers – give Vitamin D loading dose if low – Oct 2021
- French recommended 200,000 IU of Vitamin D to stop COVID-19 - Jan 2021
- Vitamin D loading dose was as effective as daily dosing (rickets in this case) – RCT July 2021
- Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
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Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D increases immunoregulatory mechanisms and has the potential to inhibit inflammageing. Since vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. Therefore we investigated the use of vitamin D3 replacement to enhance cutaneous antigen-specific immunity in older adults (≥65 years).
We showed that that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. Therefore, vitamin D3 replacement was investigated to determine if it could improve VZV-specific cutaneous immune responses in older adults. Vitamin D insufficient older adults (n=18) were administered 6400IU of vitamin D3/day orally for 14 weeks. Antigen-specific immunity to VZV was assessed using transcriptional analysis of skin biopsies collected from challenged injection sites pre- and post-vitamin D3 replacement. We showed that vitamin D3 supplementation significantly increased the response to cutaneous VZV antigen challenge in older adults. This enhancement was associated with a reduction in inflammatory monocyte infiltration with a concomitant enhancement of T cell recruitment to the site of antigen challenge in the skin.
In conclusion vitamin D3 replacement can boost antigen-specific immunity in older adults with sub-optimal vitamin D status.
Supplementary Data
ltaa008_suppl_Supplementary_Figure_1 - pdf file
ltaa008_suppl_Supplementary_Figure_2 - pdf file
ltaa008_suppl_Supplementary_Figure_Legends - docx file
ltaa008_suppl_Supplementary_Table_1 - docx file
ltaa008_suppl_Supplementary_Table_2 - xlsx file
ltaa008_suppl_Supplementary_Table_3 - xlsx file
600,000 IU of Vitamin D (total) allowed previously weak immune systems to fight off a virus antigen - Nov 2020Printer Friendly Follow this page for updates11870 visitors, last modified 08 Jan, 2021, This page is in the following categories (# of items in each category)Attached files
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