Early Growth Response Gene Upregulation in Epstein–Barr Virus (EBV)-Associated Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Biomolecules 2020, 10(11), 1484; https://doi.org/10.3390/biom10111484
by Jonathan Kerr. Dept of Microbiology, Norfolk & Norwich University Hospital (NNUH), Colney Lane
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic multisystem disease exhibiting a variety of symptoms and affecting multiple systems. Psychological stress and virus infection are important. Virus infection may trigger the onset, and psychological stress may reactivate latent viruses, for example, Epstein–Barr virus (EBV). It has recently been reported that EBV induced gene 2 (EBI2) was upregulated in blood in a subset of ME/CFS patients. The purpose of this study was to determine whether the pattern of expression of early growth response (EGR) genes, important in EBV infection and which have also been found to be upregulated in blood of ME/CFS patients, paralleled that of EBI2. EGR gene upregulation was found to be closely associated with that of EBI2 in ME/CFS, providing further evidence in support of ongoing EBV reactivation in a subset of ME/CFS patients. EGR1, EGR2, and EGR3 are part of the cellular immediate early gene response and are important in EBV transcription, reactivation, and B lymphocyte transformation. EGR1 is a regulator of immune function, and is important in vascular homeostasis, psychological stress, connective tissue disease, mitochondrial function, all of which are relevant to ME/CFS. EGR2 and EGR3 are negative regulators of T lymphocytes and are important in systemic autoimmunity.
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VitaminDWiki pages containing EPSTEIN in title
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Epstein-Barr Virus probably causes Long-COVID, CFS, and MS - many studies |
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02 Oct, 2022 |
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Epstein-Barr Virus increases the risk of many health problems – many studies |
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03 Mar, 2022 |
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Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022 |
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20 Feb, 2022 |
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COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 |
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26 Jan, 2022 |
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COVID Long-Haul predicted by 4 factors (Epstein-Barr virus, etc) – Jan 24, 2022 |
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26 Jan, 2022 |
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Epstein-Barr virus increases risk of Multiple Sclerosis by 32X - Jan 2022 |
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15 Jan, 2022 |
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Epstein Barr Virus and Chronic Fatigue Syndrome |
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12 Dec, 2021 |
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Multiple Sclerosis etc. strongly associated with Epstein-Barr virus (and vitamin D) |
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12 Dec, 2021 |
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Epstein-Barr virus appears to cause Long-Haul and Chronic fatiure Syndrome (Vitamin D might help) |
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11 Dec, 2021 |
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Epstein-Barr is yet another virus that deactivates the Vitamin D receptor (COVID later suspected as well)– 2010 |
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17 Oct, 2021 |
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Multiple Sclerosis risk increased if both Epstein-Bar Virus and low sun (vitamin D) – Aug 2021 |
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26 Aug, 2021 |
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Hypothesis of Autoimmunity which includes Epstein-Barr Virus and Vitamin D Deficiency – 2012 |
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26 Aug, 2021 |
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Vitamin D can inhibit enveloped virus (e.g. Corona, Herpes, Zoster, Epstein, Hepatitis, RSV) – March 2011 |
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07 Feb, 2021 |
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Vitamin D can inhibit enveloped virus (e.g. Herpes, Zoster, Epstein, Hepatitis) – March 2011 |
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items in category Chronic pain
See also
- Overview Pain and Vitamin D
- Overview Fibromyalgia or Chronic Fatigue and vitamin D
- Overview Rheumatoid Arthritis and vitamin D
- Shingles and vitamin D
- Shin splints decrease with vitamin D
- Migraine and Vitamin D
- Headache category
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items
- "musculoskeletal pain" 374 items as of March 2018
- "chronic fatigue" 185 items as of Jan 2017
- Category Back Pain
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items
- 5 pain studies in VitaminDWiki with KNEE in the title as of Feb 2022 (see below)
- Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021
VitaminDWiki Pain pages with FIBROMYALGIA in title
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Items found: 19
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Fibromyalgia Syndrome correlated with poor Vitamin D Receptor (less D to cells) in a small study – July 2022 |
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24 Aug, 2022 |
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Fibromyalgia and Musculoskeletal Pain treated by raised Vitamin D levels – July 2022 |
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23 Jul, 2022 |
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Overview Fibromyalgia or Chronic Fatigue and vitamin D |
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22 May, 2022 |
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Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019 |
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19 Oct, 2019 |
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Fibromyalgia severity associated with serotonin but not Vitamin D (almost all were insufficient) – May 2019 |
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27 May, 2019 |
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Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018 |
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23 Jun, 2018 |
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Fibromyalgia associated with lower Vitamin D – meta-analysis Oct 2017 |
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10 Feb, 2018 |
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Fibromyalgia benefits from transdermal magnesium chloride – Sept 2015 |
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09 Aug, 2017 |
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Fibromyalgia helped by Vitamin D – still not sure how much, and why - June 2016 |
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31 Dec, 2016 |
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Fibromyalgia development 1.9 X more likely if low vitamin D – Jan 2016 |
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20 Jan, 2016 |
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Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014 |
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05 Nov, 2015 |
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High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015 |
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11 Jul, 2015 |
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Overlap between Fibromyalgia and other Chronic Pains – 2012 |
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11 Jan, 2015 |
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Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014 |
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22 Nov, 2014 |
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7100 IU vitamin D (50,000 weekly) significantly reduced fibromyalgia – 2009 |
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19 Jan, 2014 |
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Vitamin D at CureTogether: Fibromyalgia, MS, Psorasis, etc - Dec 2013 |
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25 Dec, 2013 |
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Literature review of Fibromyalgia and vitamin D – Sept 2011 |
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18 Dec, 2013 |
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Fibromyalgia patients with low vitamin D have more pain – Dec 2013 |
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18 Dec, 2013 |
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No rise in vitamin D levels of fibromyalgia patients in the summer – Sept 2013 |
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08 Sep, 2013 |