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Breast Cancer chemo reduces Bone Mineral Density, injecting Vitamin D increases it – Sept 2019

A Longitudinal Study for the Effect of Vitamin D Adjunct to Chemotherapy on Non-Metastatic Breast Cancer Patients after Mastectomy

Breast Cancer Reports DOI : http://dx.doi.org/10.7243/2057-1631-6-1

VitaminDWiki

Trial injected 200,000 IU of vitamin D monthly for 4 months to half of the participants
Chemo typically increases BMD decline by 2X to 3X

Items in both categories Cancer - Breast    and Cancer- after diagnosis are listed here:

 Download the PDF from VitaminDWiki
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Note: Those getting Vitamin D
1) Lost weight
2) Reduce BMI
3) Reduced lumors (Vitamin D is known to improve Chemo)

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BMD INCREASED in those getting Vitamin D instead of decreasing

Ehab I. Mohamed1*, Azza M. Helal2,3, Noha M. Awad4, Gihane I. Khalil5, Amani M. Bayoumi6 and Nadia A. Abd El Moneim7
*Correspondence: Ehab I. Mohamed eimohamed at yahoo.com; ehab.abdo at alexu.edu.eg
1. Medical Biophysics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.

Background: Women with BC are at increased risk for the development of osteoporosis and skeletal fractures. We investigated the effect of CAF chemotherapy alone and adjunct to vitamin D treatment on biochemical markers of bone formation and on segmental and total bone mineral density (BMD) for non-metastatic breast cancer (NMBC) postmenopausal women who had gone through a mastectomy.

Methods: The study population was comprised of 200 NMBC women who were divided into two equal groups; before and after treatment with CAF chemotherapy alone and before and after treatment with CAF+Vitamin D treatment protocols. Other 100 healthy participants served as the Control group. All participant women were subjected to blood biochemical analysis and segmental and total BMD measurements using Dual-energy X-ray Absorptiometry technique.

Results: We found that CAF chemotherapy alone had no effect on women’s body weight, BMI, tumor marker CA15-3, PTH, ALP and Ca levels as compared to the initial state, while CAF+Vitamin D adjunct treatment caused significant reductions in their levels as compared to the initial state and Healthy Controls. We found also that CAF chemotherapy alone had no effect on plasma levels of P and Vitamin D as compared to initial state yet, CAF+Vitamin D adjunct treatment caused significant elevations in their levels as compared to the initial state and Healthy Controls.

Conclusions: Vitamin D may decrease the risk of BC recurrence by decreasing risk factors like body weight and serum levels of CA15-3, PTH, ALP, and Ca, thus increasing segmental and total BMD and decreasing the risk of osteoporosis.

Created by admin. Last Modification: Saturday September 7, 2019 21:21:24 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
12598 BMD chemo with D.jpg admin 07 Sep, 2019 19:54 34.08 Kb 37
12597 BC Chemo plus Vit D.jpg admin 07 Sep, 2019 19:54 144.27 Kb 38
12596 BC chemo BMD Vit D.pdf PDF 2019 admin 07 Sep, 2019 19:53 458.67 Kb 17
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