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Child movement disorders reduced in 1 week by Vitamin D injection (China) – Oct 2019

Clinical features of vitamin D deficiency in children: A retrospective analysis.

J Steroid Biochem Mol Biol. 2019 Oct 3:105491. doi: 10.1016/j.jsbmb.2019.105491.
Zhang X1, Liu Z2, Xia L3, Gao J4, Xu F5, Chen H6, Du Y7, Wang W8.

VitaminDWiki

All children with Vitamin D deficiency (< 15ng) were given Calcium then injected with Vitamin D 3 days later
Amazingly, the study does not seem to indicate how much Vitamin D nor Calcium was given
No mention was made of ongoing vitamin D
Injection (expensive) is generally not required

Items in both categories Intervention - non daily and Infant-Child are listed here:

Items in both categories Loading Dose and Infant-Child are listed here:

Infant-Child category has 578 items and starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

  • Sun is great – well known for 1,000’s of years.
    US govt (1934) even said infants should be out in the sun
  • One country recommended 2,000 IU daily for decades – with no known problems
  • As with adults, infants and children can have loading doses and rarely need tests
  • Daily dose appears to be best, but monthly seems OK
  • Vitamin D is typically given to infants in the form of drops
       big difference in taste between brands
       can also use water-soluable form of vitamin D in milk, food, juice,
  • Infants have evolved to get a big boost of vitamin D immediately after birth
    Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
  • 100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
    More than 100 IU/kg is probably better

Getting Vitamin D into infants
Many infants reject vitamin D drops, even when put on nipple
I speculate that the rejection is due to one or more of: additives, taste, and oils.
Infants have a hard time digesting oils, 1999  1997   and palm oils W.A. Price 1 2 3
Coconut oil, such as in D-Drops, is digested by infants. 1,   2   3
Bio-Tech Pharmacal Vitamin D has NO additves, taste, oil
One capsule of 50,000 Bio-Tech Pharmacal Vitamin D could be stirred into monthly formula
   this would result in ~1,600 IUs per day for infant, and higher dose with weight/age/formula consumption

 Download the PDF from Sci-Hub via VitaminDWiki
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Most children improved in 1 week

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Most children had 12 to 28 ng 1 month after injection

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Vitamin D is very important for children's health. Previous studies have shown that vitamin D deficiency leads to a series of diseases in adults. However, pediatricians are mostly aware of rickets caused by vitamin D deficiency in children and poorly aware of other symptoms. This study aimed to retrospectively analyze the different clinical features of vitamin D deficiency to enhance identification by pediatricians, thus minimizing misdiagnosis. In this study, we retrospectively analyzed the clinical features of vitamin D deficiency in 268 children aged 0-14 years from June 2016 to May 2018 in the Third Affiliated Hospital of Zhengzhou University. Serum 25-hydroxy vitamin D [25(OH)D] levels were determined using the chemiluminescence method.
Of the 268 cases,

  • 101 cases showed movement disorder (37.7 %) and
  • 167 nervous system abnormalities (62.3%).

Among all cases, 6 were misdiagnosed as febrile seizures (2.23%), 5 as epilepsy (1.86 %), 2 as Tourette syndrome (0.74%), and 2 as developmental retardation (0.74%).

There were significant differences in patients with clinical characteristics of movement disorder and nervous system abnormalities partly between Pre-and post-vitamin D treatment. This analysis revealed that vitamin D deficiency occurs not only in children but also in adolescents, with diverse clinical features. Therefore, pediatricians should pay more attention to clinical different signs and symptoms, and future studies should be conducted to confirm the mechanisms of these processes.

References

  1. K. A. Kennel, M. T. Drake, D. L. Hurley. Vitamin D Deficiency in Adults: When to Test and How to Treat. Mayo Clinic Proceedings, 2010, 85(8): 752-758
  2. Rathish Nair, Arun Maseeh. Vitamin D: The "sunshine" vitamin. Journal of pharmacology & pharmacotherapeutics, 2012, 3(2): 118-126
  3. S. Meeker, A. Seamons, L. Maggio-Price, et al. Protective links between vitamin D, inflammatory bowel disease and colon cancer. World J Gastroenterol, 2016, 22(3): 933-948
  4. M. J. Berridge. Vitamin D deficiency accelerates ageing and age-related diseases: a novel hypothesis. J Physiol, 2017, 595(22): 6825-6836
  5. M. F. Holick. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord, 2017, 18(2): 153-165
  6. E. Angellotti, D. D’Alessio, B. Dawson-Hughes, et al. Vitamin D Supplementation in Patients With Type 2 Diabetes: The Vitamin D for Established Type 2 Diabetes (DDM2) Study, J Endocr Soc, 2018, 2(4): 310-321
  7. U. Sethuraman, M. A. Zidan, L. Hanks, et al. Impact of vitamin D treatment on 25 hydroxy vitamin D levels and insulin homeostasis in obese African American adolescents in a randomized trial. J Clin Trans1 Endocrinol, 2018, 12: 13-19
  8. K. N. Bae, H. K. Nam, Y. J. Rhie, et al. Low levels of 25-hydroxyvitamin D in children and adolescents with type 1 diabetes mellitus: a single center experience. Ann Pediatr Endocrinol Metab, 2018, 23(1): 21-27
  9. L. Bertoccini, D. Bailetti, Summer Study in Diabetes Group, et al. Variability in genes regulating vitamin D metabolism is associated with vitamin D levels in type 2 diabetes. Oncotarget, 2018, 9(79): 34911-34918
  10. T. M. Ananda Kesavan, N. Thuruthiyath, E. P. Thomas. Subclinical Vitamin D Deficiency in Children from Thrissur, Kerala. Indian Pediatr, 2018, 55(5): 434-435
  11. J. M. Fernandez Bustillo, A. Fernandez Pombo, R. Gomez Bahamonde, et al. Vitamin D levels in a pediatric population of a primary care centre: a public health problem?, BMC Res Notes, 2018, 11(1): 801
  12. F. Wei, Z. Wang, J. Wang, et al. Serum vitamin D levels among children aged 0-12 years in the First Affiliated Hospital of Harbin Medical University, China. J Public Health (Oxf), 2018:
  13. P. Gazerani, R. Fuglsang, J. G. Pedersen, et al. A randomized, double-blinded, placebo-controlled, parallel trial of vitamin D3 supplementation in adult patients with migraine. Curr Med Res Opin, 2018: 1-9
  14. J. Dai, C. Jiang, H. Chen, et al. Vitamin D and diabetic foot ulcer: a systematic review and meta-analysis. Nutr Diabetes, 2019, 9(1): 8
  15. J. Welsh. Vitamin D and breast cancer: Past and present. J. Steroid Biochem. Mol. Biol., 2018, 177: 15-20
  16. Y. Cesur, S. A. Yuca, A. Kaya, et al. Vitamin D deficiency rickets in infants presenting with hypocalcaemic convulsions. West Indian Med J, 2013, 62(3): 201- 204
  17. M. A. Bellazzini, D. S. Howes. Pediatric hypocalcémie seizures: a case of rickets. J Emerg Med, 2005, 28(2): 161-164
  18. M. L. Gross, M. Tenenbein, E. A. Sellers. Severe vitamin D deficiency in 6 Canadian First Nation formula-fed infants. Int J Circumpolar Health, 2013, 72: 20244
  19. K. M. Bhimji, H. Naburi, S. Aboud, et al. Vitamin D Status and Associated Factors in Neonates in a Resource Constrained Setting. Int J Pediatr, 2018, 2018: 9614975
  20. D. W. Lowe, B. W. Hollis, C. L. Wagner, et al. Vitamin D insufficiency in neonatal hypoxic-ischemic encephalopathy. Pediatr Res, 2017, 82(1): 55-62
  21. G. Saggese, F. Vierucci, F. Prodam, et al. Vitamin D in pediatric age: consensus of the Italian Pediatric Society and the Italian Society of Preventive and Social Pediatrics, jointly with the Italian Federation of Pediatricians. Ital J Pediatr, 2018, 44(1): 51
  22. A. C. F. Almeida, F. J. A. de Paula, J. P. Monteiro, et al. Do all infants need vitamin D supplementation?. PLoS One, 2018, 13(4): e0195368
  23. M. Z. Chi, L. Zhu, Z. L. Zhang, et al. The Relationship between Maternal Serum Vitamin D Levels and Infant Neurodevelopment and Anthropometry: A Prospective Observational Study. J Nutr Sci Vitaminol (Tokyo), 2018, 64(2): 161-167
  24. Y. Wang, H. Li, M. Zheng, et al. Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study. PLoS One, 2018, 13(4): e0195700
  25. P. Singh. Treatment of Vitamin D Deficiency and Comorbidities: A Review. J Assoc Physicians India, 2018, 66(1): 75-82
  26. Z. A. Bhutta. Vitamin D reduces respiratory tract infections frequency. J Pediatr, 2017, 186: 209-212
  27. N. Masoudi Alavi, M. Madani, Z. Sadat, et al. Fatigue and Vitamin D Status in Iranian Female Nurses, Glob J Health Sci, 2015, 8(6): 196-202
  28. K. Johnson, M. Sattari. Vitamin D deficiency and fatigue: an unusual presentation. Springerplus, 2015, 4: 584
  29. R. Yilmaz, A. Salli, H. T. Cingoz, et al. Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. International Journal Of Rheumatic Diseases, 2016, 19(12): 1255-1262
  30. R. A. Khalifah, A. Hudairi, D. A. Homyani, et al. Vitamin D supplementation to prevent vitamin D deficiency for children with epilepsy: Randomized pragmatic trial protocol. Medicine (Baltimore), 2018, 97(40): el2734
  31. R. A1 Khalifah, A. Hudairi, D. A1 Homyani, et al. Vitamin D supplementation to prevent vitamin D deficiency for children with epilepsy Randomized pragmatic trial protocol . Medicine, 2018, 97(40): 5
  32. T. J. Song, M. K. Chu, J. H. Sohn, et al. Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine. Journal Of Clinical Neurology, 2018, 14(3): 366-373
  33. T. J. Song, M. K. Chu, J. H. Sohn, et al. Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine. J Clin Neurol, 2018, 14(3): 366-373
  34. Elspeth E. Shipton, Edward A. Shipton. Vitamin D Deficiency and Pain: Clinical Evidence of Low Levels of Vitamin D and Supplementation in Chronic Pain States. Pain and therapy, 2015, 4(1): 67-87
  35. S. Prakash, M. Kumar, P. Belani, et al. Interrelationships between chronic tension-type headache, musculoskeletal pain, and vitamin D deficiency: Is osteomalacia responsible for both headache and musculoskeletal pain?. Annals Of Indian Academy Of Neurology, 2013, 16(4): 650-658
  36. H. S. Talaat, A. M. H. Kabel, L. H. Khaliel, et al. Reduction of recurrence rate of benign paroxysmal positional vertigo by treatment of severe vitamin D deficiency. Auris Nasus Larynx, 2016, 43(3): 237-241
  37. N. Altunsoy, R. N. Yuksel, M. Cingi Yirun, et al. Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity. Nord J Psychiatry, 2018, 72(3): 221-225
  38. A. Rusinska, P. Pludowski, M. ffalczak, et al. Vitamin D Supplementation Guidelines for General Population and Groups at Risk of Vitamin D Deficiency in Poland- Recommendations of the Polish Society of Pediatric Endocrinology and Diabetes and the Expert Panel With Participation of National Specialist Consultants and Representatives of Scientific Societies-2018 Update . Front Endocrinol (Lausanne), 2018, 9: 246
  39. A. Haq, J. Svobodova, NY. Sofi, et al. Vitamin D status among the juvenile population: A retrospective study . J. Steroid Biochem. Mol. Biol., 2018, 175: 49-54
  40. L. Calderon-Garciduenas, M. Franco-Lira, A. D’Angiulli, et al. Mexico City normal weight children exposed to high concentrations of ambient PM2. 5 show high blood leptin and endothelin-1, vitamin D deficiency, and food reward hormone dysregulation versus low pollution controls. Relevance for obesity and Alzheimer disease. Environ Res, 2015, 140: 579-592
  41. M. R. Esmaeili Dooki, L. Moslemi, A. A. Moghadamnia, et al. Vitamin D status in preschool children: should vitamin D supplementation, preventing vitamin D deficiency be continued in children over 2 years?. J Public Health (Oxf), 2018:
  42. D. A. Niculescu, C. A. M. Capatina, R. Dusceac, et al. Seasonal variation of serum vitamin D levels in Romania. Arch Osteoporos, 2017, 12(1): 113
  43. A. Bleizgys, J. Kurovskij. Vitamin D Levels of Out-Patients in Lithuania: Deficiency and Hypervitaminosis. Medicina (Kaunas), 2018, 54(2):
  44. D. Chlebna-Sokol, J. Konstantynowicz, P. Abramowicz, et al. Evidence of a significant vitamin D deficiency among 9-13-year-old Polish children: results of a multicentre study. Eur J Nutr, 2018:

Created by admin. Last Modification: Monday October 7, 2019 13:16:23 GMT-0000 by admin. (Version 9)

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12740 Chinese children levels.jpg admin 07 Oct, 2019 11:55 43.33 Kb 56
12739 Chinese Children 1 week.jpg admin 07 Oct, 2019 11:55 20.55 Kb 48
12738 Chinese children.jpg admin 07 Oct, 2019 11:54 91.67 Kb 53
12737 Chinese Children injection.pdf PDF 2019 admin 07 Oct, 2019 11:54 1.53 Mb 19
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