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Vitamin D is 100X better than folic acid during pregnancy

New web page Vitamin D is at least 100 X better than Folic Acid Sept 2018

Giving Folic Acid before 2,000 births would reduce

  • 1 Spina Bifida birth
  • 100 preterm births

Note: Premature Birth is the biggest cause the death for children age 0 - 5 years.

Similar lifetime cost (about $700,000 ) of a premature birth and a Spina bifida birth
But 100X more bad birth outcomes could be prevented by Vitamin D than by Folic Acid


CDC Lifetime cost of SB $700,000

Artificial Folic acid vs natural Folate

Folic Acid increases Breast Cancer risk by 20%
Folic Acid increases colorectal cancer by 35%
Folic Acid increases risk of childhood asthma by 26%
Folic Acid 43% more likely to die from cancer.
Folic Acid, then 30 years later twice as likely to die from breast cancer
Folate was proven to reduce NTD, not Folic Acid

That folic acid may interfere with cancer has been known since the 1940’s.
Variety of RCT showed problems of Folic acid

Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study Sept 2016
High Folate in blood increased the risk of Breast Cancer by 3.2X

prevalence of open neural tube defects declined from 1 per 1000 pregnancies before fortification to 0·6 per 1000 pregnancies thereafter.

Folic acid is cheaper and easier to use than Folate

“However, it is estimated that only 15 to 25 percent of folic acid–preventable spina bifida and anencephaly worldwide is being prevented through folic acid supplementation and food fortification programs”

http://www.cochrane.org/CD006896/PREG_folic-acid-supplementation-in-pregnancy Free PDF

the correct form of what your body needs is folate
While folic acid can be converted by the body to a usable form of folate, the conversion process is limited and this frequently leads to excessive levels of unmetabolized folic acid in the blood (this is unhealthy). Furthermore – and incredibly importantly – folic acid cannot cross the placenta to the foetus, the way natural folate can.

Folic acid does prevent neural tube defects, but doesn’t have the other beneficial effects of natural folate.

Prostate Cancer 2.6X more likely if take 1 mg of Folic Acid vs placebo PDF on-line
Prostate Cancer 0.7X less likely if take Folate (Folic Acid)


US Neural tube defects: 4,200 before fortification ==> 2,900

See also VitaminDWiki

Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

See also web

  • https://examine.com/supplements/folic-acid/ Examine.Com, March 2016, extensive Folic Acid analysis
    "it appears that prolonged exposure to levels up to 250% the RDA may be associated with a relative increase in the rates of cancer, particularly colon cancer among the elderly"
  • Did you know? Folate deficiency causes breaks in DNA equivalent to 0.2 Gy of x-ray irradiation.
    This is because folate is required for the incorporation of thymidine (DNA nucleotide) into DNA and when folate is low the body substitutes uracil (RNA nucleotide) for thymidine. This means that folate deficiency is equivalent to being exposed to 0.2 Gy of ionizing radiation, a dose which is ~10 times that greater than the allowed safety limit of exposure for the general population. - Found My Fitness Oct 2017

31+ VitaminDWiki pages with FOLATE or FOLIC in the title

This list is automatically updated

Items found: 32
Title Modified
Dementia (vascular) risk increase 60% if take Folate with other B vitamins - Dec 2023 16 Dec, 2023
Folate in VitaminDWiki - many studies 08 Jul, 2023
High dose vitamin D fights Folate gene changes by COVID, autoimmune, CVD, ALZ – Oct 2022 06 Oct, 2022
Folate and Vitamin B6 decrease mortality – May 2022 27 May, 2022
Important Role of Micronutrients during COVID-19 (Zinc, Vitamin D, C, Folate) – May 5, 2021 06 May, 2021
Higher vitamin D is associated with higher Folate or higher Vitamin B-12 – June 2020 13 Jul, 2020
Sweat types, folate, binding protein, lighter skin in females and Vitamin D – Jan 2020 19 Jan, 2020
Glyphosate (Roundup) kills both weeds and the microbes in your gut that produce Folate – July 2019 11 Jul, 2019
Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019 28 Feb, 2019
Dr. Coimbra discusses Vitamin D, Magnesium, Folic Acid, B12, Autism, Depression, etc – Sept 2018 24 Nov, 2018
Dr. Coimbra interview covering Vitamin D, Magnesium, Folate, Vaccines - Oct 2018 24 Nov, 2018
Neural tube defects more likely due to low vitamin D than low Folate – April 2017 15 Sep, 2018
Vitamin D is at least 100 X better than Folic Acid 01 Sep, 2018
Vitamin D is 100X better than folic acid during pregnancy 31 Aug, 2018
Autism 17 times more likely with excessive Folic Acid and B-12 (now added to bread) – May 2016 02 Aug, 2018
Off topic – Folate can be produced by micro-organisms, can avoid synthetic Folic Acid – Aug 2018 02 Aug, 2018
Off topic: Folic Acid - the horror story (for a small percentage of people) - Sept 2013 19 Apr, 2018
Omega-3, Vitamin D, Folic acid etc. during pregnancy and subsequent mental illness of child – March 2018 29 Mar, 2018
First-Episode Psychosis associated with low Vitamin D, Vitamin C and Folate – meta-analysis Nov 2017 22 Dec, 2017
Increased cows milk allergy if Folic acid or Folate added to vitamin D during pregnancy – June 2016 05 Apr, 2017
Folic acid reduces both premature births and neural tube defects – March 2017 05 Apr, 2017
Autism 17 times more likely with excessive Folate and B-12 (now added to bread) – May 2016 09 Jun, 2016
Autism 17X more likely when have excessive levels of Folate and B-12 – May 2016 12 May, 2016
Schizophrenia might be treated by folic acid, vitamin B12 and vitamin D – May 2014 02 Dec, 2015
Vitamin D, DHA, Folic, Iodine benefits during pregnancy – July 2012 14 Oct, 2015
Vitamin D and Folate fortification of foods - April 2012 25 Apr, 2015
Neural tube defects of pregnant mice reduced by Vitamin D (perhaps less Folate needed) – April 2015 25 Apr, 2015
Health professionals: about 10X more were using Vitamin D, fish oil, folic acid by 2006 – March 2014 13 Jun, 2014
Off topic – Making birth defects ‘preventable’ Folic acid and the politics of risk reduction - Nov 2013 21 Dec, 2013
Vitamin D is not a cardiovascular fad like Vitamins C, E, Folic Acid, selenium, beta-caroteen, etc. – Circulation Nov 2013 26 Nov, 2013
Hypothesis – Increasing Folate or vitamin D decreases probability of skin cancer – July 2012 02 Aug, 2012
Birth control pills could contain Folic acid and vitamin D - Sept 2010 13 Nov, 2010
Vitamin D is 100X better than folic acid during pregnancy        
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