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Vitamin D is at least 100 X better than Folic Acid

SupplementNumber needed to treat
(Eliminate one birth problem)
Lifetime cost of a problem
Folic acid NNT = 2000 - Spina bifida $700,000
Vitamin D NNT = 20 - Premature birth$700,000,    Ref2

100 X fewer people need to take Vitamin D than Folic acid to eliminate a $700,000 lifetime risk
And, Vitamin D eliminates far more risks/costs than just preterm birth


Note: Vitamin D results in many benefits but Folic acid results in many problems

Problem
Vit D
Reduces
Vit D
Evidence
Folic Acid
Evidence
Premature birth 1 in 20 births RCT no change
Spina Bifida birth defectno data no datareduction by
1 in 2,000 births
Other birth defects Increase if gene
problem (1 in 4 women)
Chance of not conceiving3.4 X Observe perhaps helps if
the man takes Folic
Miscarriage 2.5 X Observe? ?
Pre-eclampsia 3.6 XRCT 2 X trend
Gestational Diabetes 3 X RCT 2.5 X increase
C-section - unplanned 1.6 XObserve no data
Depression AFTER pregnancy 1.4 X RCT
Small for Gestational Age 1.6 X meta-analysis1.2 X reduction
Childhood Wheezing 1.3 X RCT
Additional child is Autistic 4 X Intervention Reduces
4 X increase if gene problem
Young adult Multiple Sclerosis 1.9 XObserve no data
Preeclampsia in young adult 3.5 XRCT
Childhood Respiratory Tract visits 2.5 X RCT

See also VitaminDWiki

Recommendation - starting 12 weeks before conception

1) Take 400 ug of FOLATE (not folic acid) daily thru 8th week of pregnancy
     Do not continue taking Folate after 8th week, there is a 3.2X risk of breast cancer if high Folate in blood
2) Take at least 4,000 IU of Vitamin D daily for the rest of life, but especially thru breastfeeding
   (Use a vitamin D loading dose if had not supplemented before pregnancy)

Created by admin. Last Modification: Wednesday January 9, 2019 15:33:35 GMT-0000 by admin. (Version 53)
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