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Vitamin D is at least 100 X better than Folic Acid

SupplementNumber needed to treat
(Eliminate one birth problem)
Lifetime cost of a problem
Folic acid NNT = 2000 - Spina bifida $700,000
Vitamin D NNT = 20 - Premature birth$700,000,    Ref2

Vitamin D is thus at least 100 X more cost-effective than Folic acid

Note: Vitamin D results in many benefits but Folic acid results in many problems

Problem
Vit D
Reduces
Vit D
Evidence
Folic Acid
Evidence
Premature birth 1 in 20 births RCT no change
Spina Bifida birth defectno data no datareduction by
1 in 2,000 births
Other birth defects Increase if gene
problem (1 in 4 women)
Chance of not conceiving3.4 X Observe perhaps helps if
the man takes Folic
Miscarriage 2.5 X Observe? ?
Pre-eclampsia 3.6 XRCT 2 X trend
Gestational Diabetes 3 X RCT 2.5 X increase
C-section - unplanned 1.6 XObserve no data
Depression AFTER pregnancy 1.4 X RCT
Small for Gestational Age 1.6 X meta-analysis1.2 X reduction
Childhood Wheezing 1.3 X RCT
Additional child is Autistic 4 X Intervention Reduces
4 X increase if gene problem
Young adult Multiple Sclerosis 1.9 XObserve no data
Preeclampsia in young adult 3.5 XRCT
Childhood Respiratory Tract visits 2.5 X RCT

See also VitaminDWiki

Recommendation - starting 12 weeks before conception

1) Take 400 ug of FOLATE (not folic acid) daily thru 8th week of pregnancy
2) Take at least 4,000 IU of Vitamin D daily thru breastfeeding
   (Use a vitamin D loading dose if had not supplemented before pregnancy)

Created by admin. Last Modification: Friday September 7, 2018 13:21:43 UTC by admin. (Version 50)
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