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Higher vitamin D is associated with higher Folate or higher Vitamin B-12 – June 2020

Plasma 25-hydroxyvitamin D Is Positively Associated With Folate and Vitamin B 12 Levels in Adolescents

Nutr Res. 2020 Jun 6;79:87-99. doi: 10.1016/j.nutres.2020.06.003
Abdur Rahman 1, Abdullah Al-Taiar 2, Lemia Shaban 3, Reem Al-Sabah 4, Olusegun Mojiminiyi 5


Note: Many doctors prescribing high doses of Vitamin D also prescribe Vitamin B-12

Vitamin B12 in VitaminDWikiincludes the following

Vitamin B12 is not a cofactor of Vitamin D, but it is often needed with Vitamin D
Surfing the web finds

  • B12 deficiency increases with age
  • B12 appears to have no toxic upper limit
  • Some people get frequent B12 injections or I.V, to restore levels
    • Injection may not be needed
  • Only a small portion of B12 taken orally gets into the bloodstream
    • Sublingual B12 may not have that problem
  • B12 is stored in the liver – half-life of > 2 years - But. Dr. Greger says to take it weekly or daily
  • B12 deficiency symptoms include poor gut - which can reudce reduced uptake of Vitamin D
    • unless use gut friently forms of Vitamin D, including topical
  • B12 can be supplemented via pills, sublingual, transdermal patch, injection, emulsion, and spray
    • As with Vitamin D, a massive (loading) dose can restore levels quickly
    • Nano forms of B12 are more bio-available - as with many other supplements
56 items in Vitamin B12 category on VitaminDWiki

 Download the PDF from sci-hub VitaminDWiki

Higher Vitamin D is 35% more likely if higher Vitamin B12

Vitamin D affects the absorption of folate in vitro, and perhaps of vitamin B12 (B12). However, epidemiological studies on the association of vitamin D with folate and B12 are inconclusive. We hypothesized a positive association of plasma 25-hydroxyvitamin D 25(OH)D with folate and B12 levels in adolescents. This hypothesis was tested in a cross-sectional study of healthy adolescents (11-16 years old; n = 1416), selected from public middle schools from across Kuwait, using stratified multistage cluster random sampling. Plasma 25(OH)D was measured by LC-MS/MS. Serum B12 and total folate in hemolyzed whole blood were analyzed with commercial kits; RBC and plasma folate were calculated from total folate. Data on potential confounders were collected from the parents and adolescents. In a univariable model, 25(OH)D as a continuous variable was positively associated with each of total, RBC, and plasma folate (P < .001). After adjusting for potential confounders, this association remained significant with total folate (β = 2.0, P < .001) and red blood cell folate (β = 1.8, P < .001), but not with plasma folate (β = 0.2, P = .34). A similar pattern of association was evident when 25(OH)D was fitted as categorical variable. Correlation between B12 and 25(OH)D was weak but significant (ρ = 0.1, P < .001). 25(OH)D was positively associated with B12 in both univariable and multivariable models (P < .001) when fitted as a categorical variable only. Simultaneous quantile regression confirmed these results.

We conclude that plasma 25(OH)D is positively associated with folate and B12 levels in adolescents. Properly designed large-scale randomized controlled trials are warranted to investigate the causal role of vitamin D in folate and B12 absorption.

Created by admin. Last Modification: Monday July 13, 2020 11:39:24 GMT-0000 by admin. (Version 6)

Attached files

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14027 B12 VitD table.jpg admin 13 Jul, 2020 11:33 41.12 Kb 389
14026 Log B12.jpg admin 13 Jul, 2020 11:33 50.43 Kb 393
14025 B-12 and Vitamin D.pdf PDF 2020 admin 13 Jul, 2020 11:05 1.21 Mb 443