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Higher vitamin D is associated with higher Folate or higher Vitamin B-12 – June 2020

Plasma 25-hydroxyvitamin D Is Positively Associated With Folate and Vitamin B 12 Levels in Adolescents

Nutr Res. 2020 Jun 6;79:87-99. doi: 10.1016/j.nutres.2020.06.003
Abdur Rahman 1, Abdullah Al-Taiar 2, Lemia Shaban 3, Reem Al-Sabah 4, Olusegun Mojiminiyi 5


Note: Many doctors prescribing high doses of Vitamin D also prescribe Vitamin B-12

Vitamin B12 in VitaminDWikiincludes the following

Vitamin B12 is not a cofactor of Vitamin D, but it is often needed with Vitamin D
Surfing the web finds

  • B12 deficiency increases with age
  • B12 appears to have no toxic upper limit
  • Some people get frequent B12 injections or I.V to restore levels
    • Injection may not be needed
  • Only a small portion of B12 taken orally gets into the bloodstream
    • Sublingual B12 may not have that problem
  • B12 is stored in the liver – half-life of > 2 years - But. Dr. Greger says to take it weekly or daily
  • B12 deficiency symptoms include poor gut - which can reduce uptake of Vitamin D
    • unless use gut-friendly forms of Vitamin D, including topical
  • B12 can be supplemented via pills, sublingual, transdermal patch, injection, emulsion, and spray
    • As with Vitamin D, a massive (loading) dose can restore levels quickly
    • Nano forms of B12 are more bio-available - as with many other supplements
57 items in Vitamin B12 category on VitaminDWiki

 Download the PDF from sci-hub VitaminDWiki

Higher Vitamin D is 35% more likely if higher Vitamin B12

Vitamin D affects the absorption of folate in vitro, and perhaps of vitamin B12 (B12). However, epidemiological studies on the association of vitamin D with folate and B12 are inconclusive. We hypothesized a positive association of plasma 25-hydroxyvitamin D 25(OH)D with folate and B12 levels in adolescents. This hypothesis was tested in a cross-sectional study of healthy adolescents (11-16 years old; n = 1416), selected from public middle schools from across Kuwait, using stratified multistage cluster random sampling. Plasma 25(OH)D was measured by LC-MS/MS. Serum B12 and total folate in hemolyzed whole blood were analyzed with commercial kits; RBC and plasma folate were calculated from total folate. Data on potential confounders were collected from the parents and adolescents. In a univariable model, 25(OH)D as a continuous variable was positively associated with each of total, RBC, and plasma folate (P < .001). After adjusting for potential confounders, this association remained significant with total folate (β = 2.0, P < .001) and red blood cell folate (β = 1.8, P < .001), but not with plasma folate (β = 0.2, P = .34). A similar pattern of association was evident when 25(OH)D was fitted as categorical variable. Correlation between B12 and 25(OH)D was weak but significant (ρ = 0.1, P < .001). 25(OH)D was positively associated with B12 in both univariable and multivariable models (P < .001) when fitted as a categorical variable only. Simultaneous quantile regression confirmed these results.

We conclude that plasma 25(OH)D is positively associated with folate and B12 levels in adolescents. Properly designed large-scale randomized controlled trials are warranted to investigate the causal role of vitamin D in folate and B12 absorption.

Created by admin. Last Modification: Monday July 13, 2020 11:39:24 GMT-0000 by admin. (Version 6)

Attached files

ID Name Comment Uploaded Size Downloads
14027 B12 VitD table.jpg admin 13 Jul, 2020 41.12 Kb 454
14026 Log B12.jpg admin 13 Jul, 2020 50.43 Kb 454
14025 B-12 and Vitamin D.pdf admin 13 Jul, 2020 1.21 Mb 510