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Folic acid reduces both premature births and neural tube defects – March 2017

Periconceptional folic acid supplementation and vitamin B12 status in a cohort of Chinese early pregnancy women with the risk of adverse pregnancy outcomes.

J Clin Biochem Nutr. 2017 Mar;60(2):136-142. doi: 10.3164/jcbn.16-45. Epub 2017 Feb 8.
Yang T1, Gu Y1, Wei X1, Liang X1, Chen J1, Liu Y1, Zhang T2, Li T1.

  • 1 Children Nutrition Research Centre, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, No. 136 Zhongshan Er Rd, Yuzhong District, Chongqing 400014, China.
  • 2 Capital Institute of Pediatrics, No. 2 Yabao Er Rd, Chaoyang District, Beijing 100020, China.

I was unaware that folic acid might reduce premature births
Only 1% of the mothers were aware of the association
Vitamin D was not mentioned in the study
Wonder what % of the women who were taking folic acid were also taking vitamin D
It has been clear that folic acid prevents NTD if taken early or before pregnancy
I failed to notice as to when to take folic acid so as to reduce premature births

See also VitaminDWiki

   compares cost effetiveness of Vit D, Vit C, Omega-3 and Iodine
Healthy pregnancies need lots of vitamin D has the following summary

Vit. D
0. Chance of not conceiving3.4 times Observe
1. Miscarriage 2.5 times Observe
2. Pre-eclampsia 3.6 timesRCT
3. Gestational Diabetes 3 times RCT
4. Good 2nd trimester sleep quality 3.5 times Observe
5. Premature birth 2 times RCT
6. C-section - unplanned 1.6 timesObserve
     Stillbirth - OMEGA-3 4 timesRCT - Omega-3
7. Depression AFTER pregnancy 1.4 times RCT
8. Small for Gestational Age 1.6 times meta-analysis
9. Infant height, weight, head size
     within normal limits
10. Childhood Wheezing 1.3 times RCT
11. Additional child is Autistic 4 times Intervention
12.Young adult Multiple Sclerosis 1.9 timesObserve
13. Preeclampsia in young adult 3.5 timesRCT
14. Good motor skills @ age 31.4 times Observe
15. Childhood Mite allergy 5 times RCT
16. Childhood Respiratory Tract visits 2.5 times RCT

RCT = Randomized Controlled Trial

Search PubMed for ("folic acid" OR folate) ("premature birth" OR SGA) 156 items as of April 2017

  • Placental dysfunction is associated with altered microRNA expression in pregnant women with low folate status.
  • Effect of folic acid supplementation on preterm delivery and small for gestational age births: A systematic review and meta-analysis.
  • Maternal Continuing Folic Acid Supplementation after the First Trimester of Pregnancy Increased the Risk of Large-for-Gestational-Age Birth: A Population-Based Birth Cohort Study.
  • Effects of maternal folic acid supplementation on gene methylation and being small for gestational age.
  • Folic acid supplementation in pregnancy to prevent preterm birth: a systematic review and meta-analysis of randomized controlled trials. (2016)
  • Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery.

About a 3X reduction in preterm births and SGA if take Folic Acid


 Download the PDF from VitaminDWiki

Maternal folate and vitamin B12 deficiency predict poor pregnancy outcome. To improve pregnancy outcomes in rural area of China, we investigate rural women's folic acid supplementation (FAS) status and the associations between maternal vitamin B status during the first trimester and subsequent adverse pregnancy outcomes. We collected the questionnaire information and drew 5 ml of blood from 309 early pregnant rural women. The birth outcomes were retrieved from medical records after delivery. Out of the total, 257 had taken FAS, including 50 before conception (group A) and 207 during the first trimester (group B ). The concentration of plasma folate and the RBC folate supplementation groups were obviously higher than that of no-supplementation group (group N, p<0.01). The mean vitamin B12 levels in FAS group were significantly higher than those in groups N and B (p<0.05).
Women who delivered SGA or premature infants had reduced plasma folate levels (p<0.05) compared with controls. The multiple linear regression models revealed that RBC folate levels affected the infant birth weight (p<0.01) and birth length (p<0.05). In conclusion, FAS can significantly improve plasma folate and RBC folate levels in childbearing-age women and reduce the risk of subsequent adverse pregnancy outcomes.

PMID: 28366994 PMCID: PMC5370528 DOI: 10.3164/jcbn.16-45

Attached files

ID Name Comment Uploaded Size Downloads
7890 Folic SGA Premature 3X.jpg admin 05 Apr, 2017 41.78 Kb 742
7889 Folic T2 awareness.jpg admin 05 Apr, 2017 51.47 Kb 4424
7888 Folic Acid + B12 reduced premie rate.pdf admin 05 Apr, 2017 187.13 Kb 739