Effects of vitamin D3 supplementation on cognition and blood lipids: a 12-month randomised, double-blind, placebo-controlled trial
Journal of Neurol Neurosurg Psychiatry http://dx.doi.org/10.1136/jnnp-2018-318594
Jing Hu1, Jingya Jia1, Yanping Zhang2, Rujuan Miao1, Xiaoxu Huo1, Fei Ma1
With 400 IU for a year Vitamin D Levels 19.07 ng ==> 19.77 ng
Note: Vitamin D levels generally need to be > 30 ng to make a difference
Items of Cognition and Intervention (give Vitamin D and see what happens)
- APOE-04 Alzheimer’s progression slowed up by Omega-3 – RCT Aug 2024
- Senior cognition improved in 4 ways by Vitamin D (50,000 IU weekly for 8 weeks) – Sept 2023
- Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
- Mild cognitive decline reversed by a year of just 800 IU Vitamin D daily – RCT Dec 2020
- Methadone cognition improved by 50,000 IU of vitamin D every 2 weeks – RCT May 2019
- Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019
- Cognitive function of adult women improved in 3 months of 50,000 IU weekly Vitamin D – Jan 2019
- Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018
- Cognition improved a tiny amount with 400 IU of vitamin D (not a surprise) – RCT Oct 2018
- 9,000 dollar prize for RCT which found cognition improved after taking 4,000 IU of Vitamin D for 18 weeks – May 2018
- Senior cognition improved somewhat by 4,000 IU of Vitamin D (if initially less than 30 ng) – RCT April 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews March 2017
- Mental health intervention trials using enough vitamin D for long enough found benefits – Jan 2017
- Visual memory improved a bit by vitamin D if start with less than 30 ng – RCT Jan 2017
- Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015
- 2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004
- Better memory if take lots of vitamin D (senior rats) – May 2015
- Severe Alzheimer's delayed by 1 year with vitamin D intervention – March 2014
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- Age-related cognitive decline in rats mitigated by Vitamin D intervention – RCT Oct 2012
Items of Cognition and Meta-analysis
- Alzheimer’s 1.6X more likely if vitamin D is less than 25 ng – meta-analysis July 2023
- Alzheimer’s patients have less Magnesium – meta-analysis Jan 2022
- Delirium or cognitive problems after surgery 1.5X more likely if low vitamin D –meta-analysis Aug 2022
- 2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021
- Alzheimer’s Disease risk is 1.9 X higher if Vitamin D deficient- meta-analysis Feb 2020
- Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis Nov 2019
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Alzheimer's risk increased 7 percent for every 4 ng decrease in Vitamin D– meta-analysis Nov 2018
- Dementia is associated with low vitamin D - many studies
- Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018
- Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
- Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017
- Omega-3 helps childhood cognition – meta-analysis April 2016
- Poor cognition associated with low vitamin D in elderly (Asians now too) – meta-analysis March 2016
- Cognitive decline in elderly slowed by Omega-3 – meta-analysis May 2015
- Alzheimer’s disease 21 percent more likely if low vitamin D – meta-analysis Aug 2015
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013
- Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013
- Alzheimer's Disease more likely with low vitamin D – meta-analysis Oct 2012
- Alzheimer disease associated with 2.5 ng less vitamin D – meta-analysis Sept 2012
- Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012
Cognitive category starts with the following
Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items
see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D
Cardiovascular (
Click here for details
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023
Types of evidence that Vitamin D helps brain problems - 2014
PDF is available free at Sci-Hub 10.1136/jnnp-2018-318594
Introduction
Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy and independency in the elderly.1 Currently, no effective pharmacological interventions change the onset or progression of AD.2 Mild cognitive impairment (MCI) is possibly the earliest stage of detectable dementia and may be the optimal time to intervene.3 4 Exploring factors and biochemical markers that are associated with late-life dementia has attracted much attention. A growing body of epidemiological evidence has suggested that deficiency of nutrition components may be related to the development of cognitive decline.5
Vitamin D can play an important role in brain health and function, and exert various neuroprotective effects in brain areas essential for cognition.6 Being severely deficient in vitamin D is associated with a more than twofold increased risk of developing dementia.7 Protective effects of vitamin D on cognition and pathology are also concluded in animal models.8 9Sonnenberg et al 9 found that 1,25-dihydroxyvitamin D (1,25-D) treatment increases choline acetyltransferase activity in specific rat brain nuclei. Supplementation of vitamin D3 may have contributed to the observed improvements to memory via increasing acetylcholine concentration. Vitamin D research has gained increased attention in recent times due to its roles beyond bone health and calcium homeostasis, such as neurocognitive.10 However, results have been inconclusive.1 11 The mechanisms still remain unclear.
The brain is the most lipid-rich organ in the body,12 and almost all major classes of lipids have some correlation with AD pathogenesis.13 Several population-based studies reported that elderly people with AD or with dementia or cognitive impairment have higher plasma total cholesterol (TC) than sex and age-matched non-demented peers.14–16 Brain and peripheral lipid levels were once thought to be entirely isolated from one another by the blood–brain barrier, but recent evidence …
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