Table of contents
- Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials
- 12+ VitaminDWiki pages with NITRIC OXIDE in the title
- VitaminDWiki pages with CRP in title (8 as of April 2022)
- VitaminDWiki - Inflammation category starts with
- VitaminDWiki - Overview Magnesium and vitamin D venn relationship of Mg and Vit D
- See also: Mg and NO on PubMed
- VitaminDWiki - 30 most-recently changed items in the Magnesium Category
Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials
Nutrients 2022, 14(3), 679; https://doi.org/10.3390/nu14030679
by Nicola Veronese 1ORCID,Damiano Pizzol 2ORCID,Lee Smith 3ORCID,Ligia J. Dominguez 1,4,* andMario Barbagallo 1ORCID
Only CRP and NO were signifcantly changed by Mg
60% of trials found that CRP was reduced by Mg
Amount of NO increase - similar for the 3 trials
Magnesium trials: type, duration, and amount
Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present.
In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1.
In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
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12+ VitaminDWiki pages with NITRIC OXIDE in the title
This list is automatically updated
VitaminDWiki pages with CRP in title (8 as of April 2022)
This list is automatcially updated
VitaminDWiki - Inflammation category starts with
176 items totalExample studies
- Vitamin D reduces autoimmune, cardio, and metabolic Inflammation – Nov 2024
- Vitamin D energizes the innate and adaptive immune systems to fight lung inflammation – Sept 2022
- COVID-19 inflammation extinguished by 60,000 IU of vitamin D nanoemulsion daily for a week – RCT May 2021
- Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020
- Vitamin D reduces inflammation in critically ill patients – Sept 2020
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
- CYTOKINE in VitaminDWiki 12 titles as of July 2023
- 17 pages in VitaminDWiki had REACTIVE or CRP in title as of July 2023
- Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014
VitaminDWiki - Overview Magnesium and vitamin D venn relationship of Mg and Vit D
| Magnesium | not Magnesium | |
| Vitamin D | Magnesium or Vitamin D Aging, Amyotrophic Lateral Sclerosis, Alzheimer's Disease; Asthma, Attention Deficit Disorder, Autism, Cancer, Cerebrovascular, Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease, Heart Attack, Atherosclerosis, Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones, Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis, Peripheral vascular disease; Pregnancy-related problems, Rheumatoid Arthritis, Sports-related problems, | Vitamin D only Acne, Allergy, Autoimmune, Bone, Breathing, Celiac, Cognition, Colds and Flu, Cystic Fibrosis, Dental, Fertility, hyperparathyroid, Immunity, Kidney, Liver, Lupus, Osteoarthritis, Pain - chronic, Parkinson, Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid, Tuberculosis, Vision, Hair, Skin, Sports |
| Not Vitamin D | Magnesium only Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy, Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation, Cramps, Fluoride Toxicity, Head Injuries, Central Nervous System Injuries, Magnesium Deficiency; Menopause, Mitral Valve Prolapse, Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS, Stress, Stuttering, Tetanus; Tinnitus, Sound Sensitivity; TMJ; Toxic Shock; Violence | Neither ALL OTHER DISEASES |
See also: Mg and NO on PubMed
- Magnesium causes nitric oxide independent coronary artery vasodilation in humans - 2001 No such attachment on this page
- Effects of magnesium on nitric oxide synthase activity in endothelial cells - 1995 - https://doi.org/10.1152/ajpcell.1995.269.3.C612
- Serum Magnesium and Fractional Exhaled Nitric Oxide in Relation to the Severity in Asthma-Chronic Obstructive Pulmonary Disease Overlap - May 2021 https://doi.org/10.1007/s12011-020-02314-5
VitaminDWiki - 30 most-recently changed items in the Magnesium Category
This list is automatically updated