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Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020

Associations of C-reactive Protein with 25-hydroxyvitamin D in 24 Specific Diseases: A Cross-sectional Study from NHANES

Scientific Reports volume 10, Article number: 5883 (2020)
Fang Yang, Mengzi Sun, Chong Sun, Jiagen Li, Xiuning Yang, Chunli Bi, Min Wang, Liyuan Pu, Jianmeng Wang, Chunxiao Wang, Meizhen Xie, Yan Yao & Lina Jin

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Most diseases might be associated with acute or chronic inflammation, and the role of vitamin D in diseases has been extensively explored in recent years. Thus, we examined the associations of one of the best markers for inflammation ― C-reactive protein (CRP) with 25-hydroxyvitamin D [[[25(OH)D] in 24 specific diseases. We performed cross-sectional analyses among 9,809 subjects aged ≥18 years who participated in the U.S. National Health and Nutrition Examination Survey (NHANES) in 2007~2010. The generalized additive model (GAM) was used to explore the associations of CRP with 25(OH)D in different diseases, adjusted for the age, gender, examination period and race. Distributions of CRP were significantly different (P < 0.05) in gender, examination period and race, and distributions of 25(OH)D were different (P < 0.05) in the examination period and race. Generally, CRP was negatively associated with 25(OH)D for majority diseases. 25(OH)D was negatively associated with CRP generally, and the associations were disease-specific and disease category-specific. In respiratory, gastrointestinal and mental diseases, the associations tended to be approximately linear. While in metabolic diseases, the associations were nonlinear, and the slope of the nonlinear curve decreased with 25(OH)D, especially when 25(OH)D < 30 μg/L.

Papers that cited this one include

  • Moderator role of vitamin D concentrations on the association between metabolic syndrome and C-reactive protein among adults - Dec 2020 PDF
  • Low Serum Levels of 25-Hydroxyvitamin D Accompany Severe COVID-19 Because it is a Negative Acute Phase Reactant - June 2021PDF

VitaminDWiki - Inflammation category starts with

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VitaminDWiki pages containing REACTIVE or CRP in title

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Items found: 18
Title Modified
Higher Vitamin D in seniors is associated with lower Inflammation (CRP) – June 2023 27 Aug, 2023
Rheumatoid Arthritis pain is reduced by Vitamin D, high doses also reduced inflammation (CRP) – Meta-analysis July 2023 13 Jul, 2023
Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022 27 Jun, 2022
Inflammation (C-reactive protein) associated with low vitamin D in 22 diseases – April 2020 20 Jun, 2022
Risk of Cardiovascular disease increased 2X if both low vitamin D and high C-reactive protein – April 2019 04 Jun, 2019
C-reactive protein (heart disease marker) reduced by vitamin D – meta-analysis 2014, 2019 21 May, 2019
Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP – Aug 2017 01 Sep, 2017
Inflammatory blood markers (CRP, white blood cells) vary with Vitamin D level– Jan 2017 21 Jan, 2017
High maternal vitamin D resulted in 12 percent less inflammation (CRP) 20 years later – Oct 2016 21 Oct, 2016
Cardiovascular disease predicted by CRP and vitamin D, not cholesterol – Feb 2012 21 Oct, 2016
Inflammation (CRP) 3X higher in Winter-Spring neonates with low vitamin D – Nov 2015 10 Nov, 2015
Schizophrenia 4X less likely if both high vitamin D and high C-reactive protein – June 2015 19 Jul, 2015
Schizophrenia with high cRP is 4X less likely if high vitamin D – June 2015 17 Jul, 2015
4000 IU RCT reduces type 2 diabetes HOMA by 24% and CRP by 64% April 2010 28 Oct, 2014
Female mortality predicted better by vitamin D than by C-Reactive Protein – Dec 2013 20 Dec, 2013
Does C-Reactive Protein increase modestly with vitamin D – Jan 2012 20 Dec, 2013
Slow gait is 3.5X more likely with low vitamin D and high C-Reactive Protein – Aug 2013 16 Nov, 2013
HIV associated with low vitamin D and high C-reactive protein – Sept 2012 10 Aug, 2013

Your hs-CRP Level can be an Early Warning of Un-Diagnosed Diseases - June 2022

Here is a quick summary of what this video discusses, along with additional information and details from GrassrootsHealth:

  • Chronic, low-level inflammation has been linked to a number of chronic diseases ranging from cardiovascular disease and diabetes to mental health disorders, cancer, and osteoporosis
  • Inflammation is part of the process of breaking down and re-generating tissue, which is supposed to be re-built. In certain situations, the body is unable to re-build the tissues, and inflammation becomes continual and damaging.
  • CRP is generated by the liver when the body has a need to repair itself; it is a signal for repair that gets ‘louder’ when unable to do the repair
  • A series of studies have shown that CRP is a better predictor of cardiovascular risk than other blood tests such as cholesterol. In fact, measuring CRP allows doctors to predict your risk of having a heart attack over the next 5 to 10 years if you have risk factors for heart disease. It is also an early sign of bone weakening in osteoporosis and of many other disorders.
  • The higher the inflammation levels, the higher the risk of developing chronic disease. Sometimes an individual will experience symptoms such as joint pain or fatigue, but often times there will be no symptoms until disease occurs. Therefore, the only way to know your inflammation level is to measure it.
  • The test to use to measure levels of inflammation is the high sensitivity C-reactive protein (hs-CRP) test, also called the cardio C-reactive protein test
  • The level of hs-CRP to target is a very low level, such as 0.5 mg/L or less
  • An analysis of the GrassrootsHealth cohort showed that almost three fourths (74%) of participants had hs-CRP levels below 1.0 mg/L (low risk), 19% had levels between 1.0 and 3.0 mg/L (average risk), and 8% had levels between 3.1 and 10.0 mg/L (increased risk)
  • A high hs-CRP level indicates the body needs to repair, but is unable to. Some nutrients, including vitamin D, magnesium, and omega-3s may help the body with this repair process and lower levels of inflammation and CRP.
  • Dr. Brown discusses her favorite ways to repair… watch the video now!

Created by admin. Last Modification: Monday June 20, 2022 11:34:16 GMT-0000 by admin. (Version 13)

Attached files

ID Name Comment Uploaded Size Downloads
17918 FUNCTIONAL FEATURES.pdf PDF 2021 admin 20 Jun, 2022 11:27 357.03 Kb 126
16237 Acute Phase Reactant.pdf admin 19 Sep, 2021 18:35 70.63 Kb 192
16236 Moderator role of vitamin D.pdf PDF 2020 admin 19 Sep, 2021 18:35 199.25 Kb 199
16235 C-Reactive association.jpg admin 19 Sep, 2021 17:20 145.11 Kb 376
16234 C-reactive and vitamin D.jpg admin 19 Sep, 2021 17:20 152.07 Kb 324
16233 C-reactive and vitamin D for 24 health problems.pdf PDF 2020 admin 19 Sep, 2021 17:20 1.42 Mb 289