The effect of vitamin D supplementation on inflammation in critically ill patients: A systematic review
PharmaNutrition. Volume 13, https://doi.org/10.1016/j.phanu.2020.100196
Seyed MostafaArabiaLeila SadatBahramiaGolnazRanjbarbHamedTabeshcAbdolrezaNorouzyb
- Inflammation reduced by a single dose of Vitamin D (200,000 IU) – RCT Jan 2016
- Inhibiting Interleukin-6 to improve health (Vitamin D, etc.) - May 2020
- Inflammation is associated with low vitamin D in at least 15 diseases – April 2020
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- Inflammation and Vitamin D several studies
Items in both categories Inflammation and Trauma/Surgery are listed here:
- Little risk of infection after surgery if have more than 50 ng of vitamin D - 2014
- Vitamin D reduces inflammation in critically ill patients – Sept 2020
- Role and Mechanism of Vitamin D in Sepsis (Chinese) – Feb 2020
- Vitamin D, glutathione, and heat shock protein to treat concussions, etc. – US Patent Dec 2019
- Septic children have low Vitamin D (54 studies, ignored Vitamin D Receptor) – meta-analysis April 2019
- Urinary sepsis – a single Vitamin D injection reduced hospital days by 40 percent – RCT April 2018
- Vitamin D deficiency with severe sepsis increased risk of dying by 7.7 X – Nov 2017
- Severe sepsis may be prevented by 400,000 IU of vitamin D – RCT 2023
- Sepsis was present in 6 percent of US adult hospitalizations – JAMA Oct 2017
- 2.7 fewer days in hospital after surgery if had taken Omega-3 (19 RCT) – meta-analysis – June 2017
- Sepsis: 4 fewer days in ICU if add Omega-3 – meta-analysis of 12 RCT – June 2017
- Pro-inflammatory cytokines cause the 74 percent drop in vitamin D after knee arthroplasty – Feb 2014
- Critically ill patients with low vitamin D were 13X more likely to have a lot of mitrocondrial DNA in blood – Sept 2014
- More sepsis deaths when active vitamin D (Calcitrol) was low – May 2013
- Vitamin D decrease during inflammation is probably due to interferons - Oct 2012
- Sepsis is both prevented and treated by Vitamin D
- Inflammation or surgery or heart attack decreases measured vitamin D levels – Mar 2011
Vitamin D intervention may affect the immune system function and modulate the innate and adaptive responses in relation to the status of patients with critical illness.
The search terms were conducted on PubMed, Cochrane Library, EMBASE, Scopus, clinical trials and gray literature databases and clinical trial studies published from 2000 to July 2019 were included in the present study. Two independent researchers selected 53 studies that examined vitamin D supplementation in critically ill patients. Three researchers assessed study designs, subjects, interventions, outcomes, and data quality according to the Cochrane scoring system.
Three randomized clinical trials of critically ill patients treated with high dose of vitamin D supplements indicated consistent reductions in pro-inflammatory cytokines (interleukins 1 and 6). Five clinical trials illustrated no significant differences in C-reactive protein levels between vitamin D and placebo groups. Outcomes of secondary analyses in two trials showed no significant reduction in interleukin 6 levels (pooled effect size, IL-6, −16.32 [−40.78, 8.15]) while treated with high dose of vitamin D supplements. Moreover, vitamin D supplementation indicated no considerable effects on CRP levels in recipient group versus non-recipient group (pooled effect size −2.65 [−18.02, 12.72]).
Evidence from few clinical studies suggests that high doses of vitamin D interventions may reduce pro-inflammatory cytokines, whereas it appears to have no significant effects on anti-inflammatory cytokines and C-reactive protein levels. Further well-designed research studies are required to elucidate the effect of vitamin D supplementation on immune responses in critically ill patients.
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