J Neural Transm. 2012 May;119(5):575-9. Epub 2012 Mar 18.
Mauskop A, Varughese J.
Source: New York Headache Center, 30 East 76 Street, New York, NY, 10021, USA
Magnesium, the second most abundant intracellular cation, is essential in many intracellular processes and appears to play an important role in migraine pathogenesis. Routine blood tests do not reflect true body magnesium stores since <2 % is in the measurable, extracellular space, 67 % is in the bone and 31 % is located intracellularly. Lack of magnesium may promote cortical spreading depression, hyperaggregation of platelets, affect serotonin receptor function, and influence synthesis and release of a variety of neurotransmitters.
Migraine sufferers may develop magnesium deficiency due to
- genetic inability to absorb magnesium,
- inherited renal magnesium wasting,
- excretion of excessive amounts of magnesium due to stress,
- low nutritional intake,
and several other reasons.
There is strong evidence that magnesium deficiency is much more prevalent in migraine sufferers than in healthy controls. Double-blind, placebo-controlled trials have produced mixed results, most likely because both magnesium deficient and non-deficient patients were included in these trials. This is akin to giving cyanocobalamine in a blinded fashion to a group of people with peripheral neuropathy without regard to their cyanocobalamine levels.
Both oral and intravenous magnesium are widely available, extremely safe, very inexpensive and for patients who are magnesium deficient can be highly effective.
Considering these features of magnesium, the fact that magnesium deficiency may be present in up to half of migraine patients, and that routine blood tests are not indicative of magnesium status, empiric treatment with at least oral magnesium is warranted in all migraine sufferers.
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The items in Headache and Magnesium are listed here:
Migraines may be due to lack of lack of Magnesium in half of sufferers – May 2012
- Headaches decreased by Vitamin D, Magnesium etc. – Review March 2022
- Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022
- Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018
- Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017
- Acute Migraine 35 times more likely if low Magnesium levels – May 2016
- Migraine headaches quickly reduced with Magnesium – Meta-analysis Jan 2016
- Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022
- Migraines may be due to lack of lack of Magnesium in half of sufferers – May 2012
- Headache with vitamin D may mean you need Magnesium
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