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Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022


Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Nutrients 2022, 14(3), 679; https://doi.org/10.3390/nu14030679
by Nicola Veronese 1ORCID,Damiano Pizzol 2ORCID,Lee Smith 3ORCID,Ligia J. Dominguez 1,4,* andMario Barbagallo 1ORCID

Only CRP and NO were signifcantly changed by Mg

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60% of trials found that CRP was reduced by Mg

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Amount of NO increase - similar for the 3 trials

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Magnesium trials: type, duration, and amount

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Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present.

In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1.

In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
 Download the PDF from VitaminDWiki


VitaminDWiki pages with NITRIC OXIDE in title (7 as of April 2022)

This list is automatcially updated

Items found: 11

VitaminDWiki pages with CRP in title (8 as of April 2022)

This list is automatcially updated

Items found: 8

VitaminDWiki - Inflammation category starts with

159 items total

Example studies

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VitaminDWiki - Overview Magnesium and vitamin D venn relationship of Mg and Vit D

Magnesium not Magnesium
Vitamin D Magnesium or Vitamin D
Aging, Amytrophic Lateral Sclerosis, Alzheimer's Disease;
Asthma, Attention Deficit Disorder; Autism, Cancer, Cerebrovascular,
Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease, Heart Attack, Atherosclerosis,
Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones,
Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis; Peripheral vascular disease;
Pregnancy-related problems, Rheumatoid Arthritis; Sports-related problems,
Vitamin D only
Acne, Allergy, Autoimmune, Bone, Breathing,
Celiac, Cognition, Colds and Flu, Cystic Fibrosis,
Dental, Fertility, Hyperparathyroid, Immunity, Kidney,
Liver, Lupus, Osteoarthritis, Pain - chronic, Parkinson,
Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid,
Tuberculosis, Vision, Hair, Skin, Sports
Not Vitamin D Magnesium only
Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy,
Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation,
Cramps, Fluoride Toxicity; Head Injuries, Central Nervous System Injuries,
Magnesium Deficiency; Menopause, Mitral Valve Prolapse,
Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS,
Stress, Stuttering, Tetanus; Tinnitus, Sound Sensitivity; TMJ; Toxic Shock; Violence
Neither
ALL OTHER DISEASES

See also: Mg and NO on PubMed


VitaminDWiki - 30 most-recently changed items in the Magnesium Category

This list is automatically updated

Id Page Hits Last modification Creator Categories
14052 Low Magnesium associated with severe COVID – many studies 174
05 Dec, 2022 16:25
admin Vitamin D and Magnesium
Top news
Virus
14124 During pregnancy the levels of Vitamin D, Magnesium, and Calcium drop – Nov 2022 51
01 Dec, 2022 22:26
admin Pregnancy
Vitamin D and Magnesium
6178 Transdermal Magnesium Chloride spray - variable responses, removed toxic metals - 2010 4252
30 Nov, 2022 19:41
admin Vitamin D and Magnesium
12016 ADHD risk factors include low Zinc, Vitamin D, Magnesium and Omega-3 (umbrella review) – Oct 2020 1056
30 Nov, 2022 04:02
admin Vitamin D and Magnesium
Infant-Child
Vitamin D and Omega-3
Zinc
ADHD
14121 ADHD significantly treated by daily Magnesium plus weekly Vitamin D – RCT April 2021 105
30 Nov, 2022 03:46
admin Vitamin D and Magnesium
ADHD
11081 Behavior disorders reduced with Magnesium, Omega-3, and Zinc 3471
29 Nov, 2022 20:42
admin Vitamin D and Magnesium
Infant-Child
Vitamin D and Omega-3
Zinc
ADHD
6743 Vitamin D Cofactors in a nutshell 69477
28 Nov, 2022 13:42
admin Supplement
Vitamin D and Calcium
Vitamin D and Magnesium
Vitamin D and Vitamin K
Vitamin D and Vitamin A
Vitamin D and Boron
Vitamin D and Omega-3
Vitamin D and Iron
Zinc
Iodine
Vitamin B12
Resveratrol
Curcumin
Vitamin C
1270 Low cost cofactors for vitamin D 126093
20 Nov, 2022 19:52
admin Vitamin D and Calcium
Vitamin D and Magnesium
Top news
Vitamin D and Vitamin K
Vitamin D and Vitamin A
Vitamin D and Boron
Vitamin D and Omega-3
Vitamin D and Iron
Zinc
13500 COVID death 6.9X less likely if high Magnesium to Calcium ratio – April 2022 330
19 Nov, 2022 11:10
admin Vitamin D and Magnesium
Virus
13349 Lower Magnesium, 6 percent more COVID - Feb 2022 1325
19 Nov, 2022 10:03
admin Skin - Dark
Vitamin D and Magnesium
Virus
3437 Headache 51557
15 Nov, 2022 21:51
ricks99 Vitamin D and Magnesium
Headache
Category
Associations
13829 Calcium to Magnesium Ratio - many studies 6645
14 Nov, 2022 17:41
admin Vitamin D and Calcium
Vitamin D and Magnesium
13452 Long Covid, Short Magnesium - Chambers April 2022 2379
30 Oct, 2022 23:30
admin Vitamin D and Magnesium
Virus
14060 Fatigue and other long-haul problems appear to be associated with low Magnesium - Chambers Oct 2022 610
30 Oct, 2022 23:27
admin Vitamin D and Magnesium
Virus
5116 Magnesium and Vitamin D 64164
30 Oct, 2022 23:14
admin Vitamin D and Magnesium
Category
13713 Magnesium Role in Health and Longevity - many studies 614
18 Oct, 2022 21:33
admin Mortality and D
Vitamin D and Magnesium
7277 Magnesium increases Vitamin D and decreases mortality - 2013 7912
09 Oct, 2022 00:53
admin Vitamin D and Magnesium
947 Overview Magnesium and vitamin D 334940
09 Oct, 2022 00:51
admin Obesity
Vitamin D and Magnesium
Overviews
Associations
13948 Magnesium reduces hypertenion - FDA allows claim - Jan 2022 146
28 Sep, 2022 16:57
admin Vitamin D and Magnesium
Hypertension
13939 You are probably unaware that health needs a Ca-Mg ratio of 2 – Sept 2022 255
26 Sep, 2022 17:49
admin Vitamin D and Calcium
Vitamin D and Magnesium
13571 Magnesium reduces pain - many studies 763
17 Sep, 2022 23:20
admin Pain - chronic
Vitamin D and Magnesium
Top news
13898 Cystic Fibrosis is associated with low Magnesium, supplementation would probably help -review 2016 147
09 Sep, 2022 20:19
admin Vitamin D and Magnesium
Cystic Fibrosis
13517 Half of Cystic Fibrosis patients have low Magnesium levels – April 2022 440
09 Sep, 2022 20:17
admin Vitamin D and Magnesium
Cystic Fibrosis
6734 Atrial Fibrillation - remineralize your heart - Aug 2015 6570
07 Sep, 2022 12:33
admin Cardiovascular
Books, videos on Vitamin D
Vitamin D and Magnesium
9736 Ablation does not reduce atrial fibrillation (CABANA study) but Magnesium does – June 2018 2744
07 Sep, 2022 12:21
admin Cardiovascular
Vitamin D and Magnesium
12919 Atrial Fibrillation in VitaminDWiki - many studies 3386
07 Sep, 2022 12:11
admin Cardiovascular
Vitamin D and Magnesium
Vitamin D and Omega-3
13853 PCOS also fought by Magnesium combinations – review Aug 2022 225
22 Aug, 2022 14:59
admin Vitamin D and Magnesium
Fertility and sperm
Women
8795 Magnesium in Healthcare (Rickets, Stones, Pregnancy, Depression, etc.) with level of evidence – Sept 2017 6790
05 Aug, 2022 00:01
admin Pregnancy
Rickets
Depression
Cancer
Vitamin D and Magnesium
Headache
Overview for doctors
Kidney Stones
Metabolic Syndrome
Top news
13822 Magnesium reference ranges – 43 now, suggest a low of 0.85 nmol (2.07 mg) – July 2022 292
04 Aug, 2022 23:53
admin Vitamin D and Magnesium
10020 Hypothesis: Magnesium might prevent and treat Chronic Kidney Disease – April 2018 2159
04 Aug, 2022 13:19
admin Kidney
Vitamin D and Magnesium

Created by admin. Last Modification: Monday June 27, 2022 15:42:59 GMT-0000 by admin. (Version 16)

Attached files

ID Name Comment Uploaded Size Downloads
17989 Mg increase NO.jpg admin 27 Jun, 2022 15:20 20.36 Kb 95
17988 statistically significant.jpg admin 27 Jun, 2022 15:19 19.69 Kb 102
17459 CRP Mg table.jpg admin 20 Apr, 2022 14:22 143.38 Kb 147
17457 CRP reduction by Magnseium.jpg admin 20 Apr, 2022 14:14 28.45 Kb 139
17456 Magnesium resuces Inflammation.pdf PDF 2022 admin 20 Apr, 2022 14:14 989.96 Kb 126
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