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Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022


Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Nutrients 2022, 14(3), 679; https://doi.org/10.3390/nu14030679
by Nicola Veronese 1ORCID,Damiano Pizzol 2ORCID,Lee Smith 3ORCID,Ligia J. Dominguez 1,4,* andMario Barbagallo 1ORCID

Only CRP and NO were signifcantly changed by Mg

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60% of trials found that CRP was reduced by Mg

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Amount of NO increase - similar for the 3 trials

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Magnesium trials: type, duration, and amount

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Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present.

In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1.

In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
 Download the PDF from VitaminDWiki


VitaminDWiki pages with NITRIC OXIDE in title (7 as of April 2022)

This list is automatcially updated

Items found: 10

VitaminDWiki pages with CRP in title (8 as of April 2022)

This list is automatcially updated

Items found: 8

VitaminDWiki - Inflammation category starts with

151 items total

Example studies

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VitaminDWiki - Overview Magnesium and vitamin D venn relationship of Mg and Vit D

Magnesium not Magnesium
Vitamin D Magnesium or Vitamin D
Aging, Amytrophic Lateral Sclerosis, Alzheimer's Disease;
Asthma, Attention Deficit Disorder; Autism, Cancer, Cerebrovascular,
Chronic Fatigue, Diabetes, Hearing Loss, Heart Disease, Heart Attack, Atherosclerosis,
Cardiovascular Disease, HIV, AIDS; Hypertension; Kidney Stones,
Migraine Headache, Multiple Sclerosis, Obesity, Osteoporosis; Peripheral vascular disease;
Pregnancy-related problems, Rheumatoid Arthritis; Sports-related problems,
Vitamin D only
Acne, Allergy, Autoimmune, Bone, Breathing,
Celiac, Cognition, Colds and Flu, Cystic Fibrosis,
Dental, Fertility, Hyperparathyroid, Immunity, Kidney,
Liver, Lupus, Osteoarthritis, Pain - chronic, Parkinson,
Psoriasis, Rickets, Strokes, Sarcoidosis, Thyroid, Parathyroid,
Tuberculosis, Vision, Hair, Skin, Sports
Not Vitamin D Magnesium only
Aggressive Behavior, Alcoholism, Arrhythmia, Cerebral Palsy,
Chemical Sensitivity, Cluster Headaches; Cocaine-related Stroke; Constipation,
Cramps, Fluoride Toxicity; Head Injuries, Central Nervous System Injuries,
Magnesium Deficiency; Menopause, Mitral Valve Prolapse,
Nystagmus, Psychiatric Disorders; Repetitive Strain Injury, Sickle Cell Disease, SIDS,
Stress, Stuttering, Tetanus; Tinnitus, Sound Sensitivity; TMJ; Toxic Shock; Violence
Neither
ALL OTHER DISEASES

See also: Mg and NO on PubMed


VitaminDWiki - 30 most-recently changed items in the Magnesium Category

This list is automatically updated

Id Page Hits Last modification Creator Categories
5410 Fructose (High Fructose Corn Syrup) consumes 2X more Magnesium than sugar – May 2014 8083
28 Jun, 2022 01:49
admin Deficiency of Vitamin D
Vitamin D and Magnesium
Top news
13452 Long Covid, Short Magnesium - April 2022 1124
27 Jun, 2022 17:48
admin Vitamin D and Magnesium
Virus
13501 Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022 233
27 Jun, 2022 15:42
admin Vitamin D and Magnesium
Inflammation
13713 Magnesium Role in Health and Longevity - 2018 135
27 Jun, 2022 02:41
admin Mortality and D
Vitamin D and Magnesium
13706 Intracellular Magnesium and Vitamin D - a few studies 159
24 Jun, 2022 01:36
admin Vitamin D and Magnesium
947 Overview Magnesium and vitamin D 324837
23 Jun, 2022 18:07
admin Obesity
Vitamin D and Magnesium
Overviews
Associations
13627 Hypertension treatment needs at least 600 mg of Magnesium (49 trials) – Jan 2021 187
18 Jun, 2022 13:57
admin Vitamin D and Magnesium
Hypertension
13668 Hypertension reduced by Magnesium plus 3,000 IU of vitamin D for 12 weeks – RCT July 2022 117
13 Jun, 2022 01:46
admin Vitamin D and Magnesium
Intervention
Hypertension
10310 Magnesium and Vitamin D - pre-colon cancer – RCT Dec 2018 2487
13 Jun, 2022 00:07
admin Cancer - Colon
Vitamin D and Magnesium
13656 COVID and Magnesium - hypothesis, clinical trials, Long-Haul - Oct 2021 151
10 Jun, 2022 01:47
admin Vitamin D and Magnesium
Virus
13654 Low magnesium if poor kidney, poor gut, cancer, cancer drugs – Jan 2021 71
09 Jun, 2022 22:35
admin Kidney
Vitamin D and Magnesium
13653 More Magnesium needed to decrease diabetes, cardio, HT (body weight has increased) - March 2021 73
09 Jun, 2022 14:15
admin Cardiovascular
Diabetes
Vitamin D and Magnesium
Hypertension
13639 Treating pre-diabetes with Magnesium Chloride should be cost effective – June 2022 84
09 Jun, 2022 01:58
admin Diabetes
Vitamin D and Magnesium
13637 Magnesium deficiency level should be raised from .75 to .85 – April 2021 64
09 Jun, 2022 01:53
admin Vitamin D and Magnesium
13650 Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022 91
08 Jun, 2022 19:40
admin Diabetes
Vitamin D and Magnesium
5116 Magnesium and Vitamin D 62564
08 Jun, 2022 16:39
admin Vitamin D and Magnesium
Category
13641 Magnesium supplementation prevents recurrence of renal stones – 2019 63
06 Jun, 2022 16:33
admin Vitamin D and Magnesium
Kidney Stones
13638 Magnesium helps bones a bit – meta-analysis Jan 2022 66
05 Jun, 2022 19:33
admin Bone - Health
Vitamin D and Magnesium
13378 Headaches decreased by Vitamin D, Magnesium etc. – Review March 2022 576
05 Jun, 2022 17:43
admin Vitamin D and Magnesium
Headache
Vitamin B12
13636 Exercise Performance improved by Vitamin D or Magnesium – 2021 81
05 Jun, 2022 17:41
admin Sports and Vitamin D
Vitamin D and Magnesium
13628 Magnesium: intake decreased, difficult to measure in body – Sept 2018 105
05 Jun, 2022 17:06
admin Vitamin D and Magnesium
13624 Four Magnesium Deficiency Questionnaires for women - July 2020 88
05 Jun, 2022 16:42
admin Vitamin D and Magnesium
13626 Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021 150
02 Jun, 2022 18:47
admin Diabetes
Obesity
Vitamin D and Magnesium
Metabolic Syndrome
13625 Magnesium and Mortality – June 2020 128
02 Jun, 2022 11:19
admin Mortality and D
Vitamin D and Magnesium
13623 Magnesium is important to health – March 2021 130
02 Jun, 2022 01:02
admin Vitamin D and Magnesium
13610 Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022 143
29 May, 2022 16:08
admin Depression
Vitamin D and Magnesium
Vitamin D and Omega-3
12919 Atrial Fibrilation in VitaminDWiki 607
26 May, 2022 15:44
admin Cardiovascular
Vitamin D and Magnesium
Vitamin D and Omega-3
13571 Magnesium reduces pain - many studies 197
19 May, 2022 11:49
admin Pain - chronic
Vitamin D and Magnesium
13451 Short-term response to 1,000 IU of Vitamin D tripled in obese when Magnesium was added – RCT April 2022 232
17 May, 2022 13:11
admin Vitamin D and Magnesium
Intervention
6868 Pregnancy helped by Magnesium in many ways 8475
12 May, 2022 19:46
admin Pregnancy
Vitamin D and Magnesium
Top news

Created by admin. Last Modification: Monday June 27, 2022 15:42:59 GMT-0000 by admin. (Version 16)

Attached files

ID Name Comment Uploaded Size Downloads
17989 Mg increase NO.jpg admin 27 Jun, 2022 15:20 20.36 Kb 26
17988 statistically significant.jpg admin 27 Jun, 2022 15:19 19.69 Kb 39
17459 CRP Mg table.jpg admin 20 Apr, 2022 14:22 143.38 Kb 79
17457 CRP reduction by Magnseium.jpg admin 20 Apr, 2022 14:14 28.45 Kb 65
17456 Magnesium resuces Inflammation.pdf PDF 2022 admin 20 Apr, 2022 14:14 989.96 Kb 36
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