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Magnesium reduces inflammation (CRP) and increases nitric oxide – meta-analysis Feb 2022


Effect of Magnesium Supplementation on Inflammatory Parameters: A Meta-Analysis of Randomized Controlled Trials

Nutrients 2022, 14(3), 679; https://doi.org/10.3390/nu14030679
by Nicola Veronese 1ORCID,Damiano Pizzol 2ORCID,Lee Smith 3ORCID,Ligia J. Dominguez 1,4,* andMario Barbagallo 1ORCID

Only CRP and NO were signifcantly changed by Mg

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60% of trials found that CRP was reduced by Mg

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Amount of NO increase - similar for the 3 trials

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Magnesium trials: type, duration, and amount

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Magnesium (Mg) may have several beneficial effects on human health outcomes. One hypothesized mechanism eliciting such effects is the action of Mg on serum inflammatory parameters. However, studies on this topic to date have several important limitations. Therefore, the present systematic review and meta-analysis aimed to summarize the current state of the art of all randomized control trials (RCTs) investigating the effects of Mg supplementation versus placebo on serum parameters of inflammation. We searched several databases until 23 November 2021 for RCTs. Eligible studies were RCTs investigating the effect of oral Mg supplementation vs. placebo and having serum inflammatory markers as an outcome. Among 2484 papers initially screened, 17 randomized controlled trials (889 participants; mean age: 46 years; females: 62.5%) were included. Generally, a low risk of bias was present.

In meta-analysis, Mg supplementation significantly decreased serum C reactive protein (CRP) and increased nitric oxide (NO) levels. In descriptive findings, Mg supplementation significantly reduced plasma fibrinogen, tartrate-resistant acid phosphatase type 5, tumor necrosis factor-ligand superfamily member 13B, ST2 protein, and IL-1.

In conclusion, Mg supplementation may significantly reduce different human inflammatory markers, in particular serum CRP and NO levels.
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12+ VitaminDWiki pages with NITRIC OXIDE in the title

This list is automatically updated

Items found: 12

VitaminDWiki pages with CRP in title (8 as of April 2022)

This list is automatcially updated

Items found: 11

VitaminDWiki - Inflammation category starts with

168 items total

Example studies

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VitaminDWiki - Overview Magnesium and vitamin D venn relationship of Mg and Vit D


See also: Mg and NO on PubMed


VitaminDWiki - 30 most-recently changed items in the Magnesium Category

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Id Page Hits Last modification Creator Categories
2296 Reasons for low response to vitamin D 86735
04 Mar, 2024 03:06
admin Skin - Dark
How much Vitamin D
Obesity
Vitamin D and Magnesium
Interactions with Vitamin D
Gut
Vitamin D and Vitamin K
Vitamin D and Boron
Vitamin D and Omega-3
Predict Vitamin D
Antibiotics, probiotics
14685 Muscles improved in women with 50,000 IU vitamin D weekly (8 weeks) plus daily Magnesium – RCT Sept 2020 870
29 Feb, 2024 16:41
admin Vitamin D and Magnesium
Intervention
Falls and Fractures
Women
Intervention - non daily
6743 Vitamin D Cofactors in a nutshell 84931
27 Feb, 2024 23:43
admin Supplement
Vitamin D and Calcium
Vitamin D and Magnesium
Vitamin D and Vitamin K
Vitamin D and Vitamin A
Vitamin D and Boron
Vitamin D and Omega-3
Vitamin D and Iron
Zinc
Iodine
Vitamin B12
Resveratrol
Curcumin
Vitamin C
12442 Patients on Hemodialysis 3X more likely if die of heart failure if low Magnesium – meta-analysis Jan 2021 2503
25 Feb, 2024 12:38
admin Kidney
Mortality and D
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13610 Anxiety, depression, and suicide have recently surged (Note: Vitamin D, Omega-3, and Magnesium help) – May 2022 1440
23 Feb, 2024 13:27
admin Depression
Vitamin D and Magnesium
Vitamin D and Omega-3
15065 Magnesium Pidolate may be a good form to reduce headaches – Aug 2020 124
20 Feb, 2024 16:49
admin Vitamin D and Magnesium
Headache
AI
3437 Headache 62186
20 Feb, 2024 16:28
ricks99 Vitamin D and Magnesium
Headache
Category
Associations
744 Headache with vitamin D may mean you need Magnesium 142743
20 Feb, 2024 14:03
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Headache
5724 Restless Legs Syndrome dramatically reduced by vitamin D, etc 213936
18 Feb, 2024 17:19
admin Vitamin D and Magnesium
Intervention
Sleep
Vitamin D and Iron
13948 Magnesium reduces hypertension - FDA allows claim - Jan 2022 759
07 Feb, 2024 18:32
admin Vitamin D and Magnesium
Hypertension
10009 Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018 3887
28 Jan, 2024 00:00
admin Vitamin D and Magnesium
Headache
Intervention
7277 Magnesium increases Vitamin D and decreases mortality - 2013 8821
26 Jan, 2024 14:05
admin Vitamin D and Magnesium
14220 Co-factors increase Vitamin D response for the GRH cohort - Jan 2023 2407
25 Jan, 2024 22:12
admin Supplement
Vitamin D and Magnesium
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14950 After stroke, 40% less likely to die if 400 mg of Magnesium daily - Oct 2023 397
06 Jan, 2024 00:37
admin Mortality and D
Vitamin D and Magnesium
Stroke
2431 100 mg more Magnesium in water associated with 8 percent reduction in stroke – Feb 2012 5661
05 Jan, 2024 21:14
admin Vitamin D and Magnesium
Stroke
14815 How Vitamin D, Omega-3s, and Exercise May Increase Longevity - Patrick Nov 2023 728
15 Dec, 2023 19:32
admin Books, videos on Vitamin D
Vitamin D and Magnesium
Vitamin D and Omega-3
947 Overview Magnesium and vitamin D 368971
09 Dec, 2023 19:47
admin Obesity
Vitamin D and Magnesium
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Associations
AI
5116 Magnesium and Vitamin D 69910
09 Dec, 2023 19:36
admin Vitamin D and Magnesium
Category
8541 Depression greatly reduced by taking 250 mg of Magnesium Chloride daily for 6 weeks– RCT June 2017 8389
06 Dec, 2023 17:34
admin Depression
Vitamin D and Magnesium
14859 The ONE Supplement All Longevity Experts Are Taking (Magnesium) - video and transcript Dec 2023 611
04 Dec, 2023 16:28
admin Books, videos on Vitamin D
Vitamin D and Magnesium
14706 Longevity experts take Vitamin D, Omega-3, and Magnesium - Patrick video Sept 2023 1036
30 Nov, 2023 15:43
admin Mortality and D
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1976 Weight loss and Vitamin D, Calcium, and Magnesium 23628
13 Nov, 2023 17:53
admin Obesity
Vitamin D and Calcium
Vitamin D and Magnesium
12919 Atrial Fibrillation decreased by Vitamin D or Magnesium - many studies 25077
11 Nov, 2023 19:36
admin Cardiovascular
Vitamin D and Magnesium
Vitamin D and Omega-3
8423 Vitamin D supplementation often needs Magnesium – May 2017 7146
10 Nov, 2023 12:15
admin Vitamin D and Magnesium
13493 Excellent reviews of supplements at ConsumerLab 3151
17 Oct, 2023 18:06
admin Supplement
Vitamin D and Calcium
Vitamin D and Magnesium
Vitamin D and Vitamin K
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Zinc
Iodine
Vitamin B12
Resveratrol
Curcumin
Vitamin C
14755 7 Factors that Make People Likely to be Magnesium Deficient - GRH Oct 2023 477
16 Oct, 2023 12:37
admin Vitamin D and Magnesium
13348 Cluster Headaches treated by high-dose Vitamin D, etc. (interview and transcript) - Feb 2022 12006
28 Sep, 2023 18:10
admin Vitamin D and Magnesium
Headache
Top news
Vitamin D and Omega-3
Zinc
4597 Cluster headaches virtually eliminated in 7,000 people with high-dose vitamin D and cofactors - Feb 2022 182182
28 Sep, 2023 18:10
admin Vitamin D and Magnesium
Headache
Intervention
Top news
Vitamin D and Omega-3
Optimum
Zinc
High-Dose
13531 Nitric oxide increased by UVA, Vitamin D, Magnesium, etc, 1596
27 Sep, 2023 18:05
admin Cardiovascular
Vitamin D and Magnesium
14698 Supplements taken by the founder of VitaminDWiki 2638
25 Sep, 2023 16:33
admin Supplement
Vitamin D and Magnesium
Vitamin D and Vitamin K
Vitamin D and Boron
Zinc
Iodine
Vitamin B12
Resveratrol
Curcumin
Vitamin C

Created by admin. Last Modification: Friday September 22, 2023 13:24:17 GMT-0000 by admin. (Version 17)

Attached files

ID Name Comment Uploaded Size Downloads
17989 Mg increase NO.jpg admin 27 Jun, 2022 20.36 Kb 219
17988 statistically significant.jpg admin 27 Jun, 2022 19.69 Kb 240
17459 CRP Mg table.jpg admin 20 Apr, 2022 143.38 Kb 357
17457 CRP reduction by Magnseium.jpg admin 20 Apr, 2022 28.45 Kb 284
17456 Magnesium resuces Inflammation.pdf admin 20 Apr, 2022 989.96 Kb 221