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Multiple Sclerosis half as likely if get plenty of sunshine (not a news item) – March 2018

Sun exposure over the life course and associations with multiple sclerosis

March 7, 2018, DOI: https://doi.org/10.1212/WNL.0000000000005257
Helen Tremlett, Feng Zhu, Alberto Ascherio and Kassandra L. Munger

Free PDF was on Sci-Hub.tc March 2018

Objective To examine sun exposure and multiple sclerosis (MS) over the life course (ages 5–15 and 16–20 years, every 10 years thereafter).

Methods Cases with MS (n = 151) and age-matched controls (n = 235) from the Nurses' Health Study cohorts completed summer, winter, and lifetime sun exposure history questionnaires. Cumulative ambient ultraviolet (UV)-B (based on latitude, altitude, cloud cover) exposure before MS onset was expressed as tertiles. Seasonal sun exposure was defined as low vs high hours per week (summer [≤9 vs >10 h/wk]; winter [≤3 vs >4 h/wk]). Relative risks (RRs) and 95% confidence intervals (CIs) were estimated via conditional logistic regression with adjustment for body mass index, ancestry, smoking, and vitamin D supplementation.

Results Most participants were white (98%); the mean age at MS onset was 39.5 years. Living in high (vs low) UV-B areas before MS onset was associated with a 45% lower MS risk (adjusted RR 0.55, 95% CI 0.42–0.73).
Similar reduced risks (51%–52%) for medium or high exposure were observed at ages 5 to 15 years and at 5 to 15 years before MS onset (adjusted p < 0.05).
At age 5 to 15 years, living in a high (vs low) UV-B area and having high (vs low) summer sun exposure were associated with a lower MS risk (RR 0.45, 95% CI 0.21–0.96).

Conclusion Living in high ambient UV-B areas during childhood and the years leading up to MS onset was associated with a lower MS risk. High summer sun exposure in high ambient UV-B areas was also associated with a reduced risk.

Created by admin. Last Modification: Thursday March 8, 2018 20:21:20 UTC by admin. (Version 6)
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