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Pandemic Vitamin D levels dropped by 3.3 ng (perhaps less D, more health problems) – May 2022

Effect of the COVID-19 Pandemic on Serum Vitamin D Levels in People Under Age 18 Years: A Systematic Review and Meta-Analysis

Med Sci Monit. 2022 May 25;28:e935823. doi: 10.12659/MSM.935823.
Xian Cui 1, Yuhang Zhai 2, Shuai Wang 1, Ke Ding 1, Zhenya Yang 1, Yan Tian 1, Tingting Huo 1

BACKGROUND During the COVID-19 pandemic the implementation of a range of measures to suppress transmission, such as social distancing and home confinement resulted in limited sunlight exposure and physical inactivity in people under age 18 years, which can elevate the risk of vitamin D deficiency and insufficiency. The aim of this study was to systemically evaluate the effect of the COVID-19 pandemic on serum vitamin D levels in people under age 18 years.

MATERIAL AND METHODS Following the PRISMA recommendations, we searched PubMed, Embase, and the Cochrane Database for trials from inception to November 3, 2021. All trials assessing the effects of the COVID-19 pandemic on serum vitamin D levels in people under age 18 years were included and analyzed. Mean differences (MDs) of serum 25-hydroxyvitamin D (25[OH] D) levels before and during the COVID-19 pandemic were calculated and pooled using a random-effects model. Risk differences were used to assess changes in the proportions of people under age 18 years with vitamin D deficiency.

RESULTS Our analysis included 5 studies comprising 4141 people under age 18 years. The combined result MD of serum 25(OH)D levels before and during the COVID-19 pandemic as 3.28 ng/mL, 95% CI=0.95-5.62 ng/mL, P<0.01] indicated serum 25(OH)D levels were significantly lower during the COVID-19 pandemic. The decreased serum 25(OH)D level was not observed among infants (age under 1 year) (P=0.28).

CONCLUSIONS During the COVID-19 pandemic, the serum vitamin D levels of people under age 18 years were significantly lower and vitamin D supplementation for people under age 18 years might reduce the risk of COVID-19. More research is needed to validate the present findings.
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Levels dropped due to one or more of: 1) Less sun, 2) Viral infection, 3) Vaccinations

Also: Many viruses deactivate the Vitamin D Receptor to protect themselves

33 studies in both categories Virus and Vitamin D Receptor

This list is automatically updated

Examples of enveloped virus   Coronavirus, Herpes simplex (cold sore), Shingles, Epstein-Barr, Hepatitis A & B & C, Zika, HIV, Dengue, Yellow fever, Measles, Mumps, smallpox, monkeypox, ebola, rabies, influenza A & B, West Nile, Valley Fever, Croup, Lasa Fever, Hemorrhagic Fever, H5N1 bird flu

Additional studies observed Vitamin D dropping during pandemic

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  • 2. Ita K. Coronavirus disease (COVID-19): Current status and prospects for drug and vaccine development. Arch Med Res. 2021;52:15-24
  • 3. Dusso AS, Brown AJ, Slatopolsky E. Vitamin D. Am J Physiol Renal Physiol. 2005;289:F8-28
  • 4. Harrison HE. Vitamin D. Prog Clin Biol Res. 1981;61:95-108
  • 5. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18:153-65
  • 6. Holick MF, Chen TC. Vitamin D deficiency: A worldwide problem with health consequences. Am J Clin Nutr. 2008;87:1080S-86S
  • 7. Grant WB, Lahore H, McDonnell SL, et al. Evidence that Vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths. Nutrients. 2020;12:988
  • 8. Jolliffe DA, Camargo CA Jr., Sluyter JD, et al. Vitamin D supplementation to prevent acute respiratory infections: A systematic review and meta-analysis of aggregate data from randomised controlled trials. Lancet Diabetes Endocrinol. 2021;9:276-92
  • 9. Mitchell F. Vitamin-D and COVID-19: Do deficient risk a poorer outcome? Lancet Diabetes Endocrinol. 2020;8:570
  • 10. Yilmaz K, Sen V. Is vitamin D deficiency a risk factor for COVID-19 in children? Pediatr Pulmonol. 2020;55:3595-601
  • 11. Panfili FM, Roversi M, D'Argenio P, et al. Possible role of vitamin D in COVID-19 infection in pediatric population. J Endocrinol Invest. 2021;44:27-35
  • 12. Rustecka A, Maret J, Drab A, et al. The impact of COVID-19 Pandemic during 2020-2021 on the Vitamin D serum levels in the paediatric population in Warsaw, Poland. Nutrients. 2021;13:1990
  • 13. Wong RS, Tung KTS, So HK, et al. Impact of COVID-19 pandemic on serum vitamin D level among infants and toddlers: An interrupted time series analysis and before-and-after comparison. Nutrients. 2021;13:1270
  • 14. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ. 2021;372:n71
  • 15. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: An Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-30
  • 16. Wells G, Shea B, O'Connel D, et al. The Newcastle Ottawa Scale (NOS) for assessing the quality of non-randomised studies in meta-analysis. In: Proceedings of the Third Symposium on Systematic Reviews. England: Oxford; 2000
  • 17. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557-60
  • 18. Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50:1088-101
  • 19. Egger M, Davey Smith G, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997;315:629-34
  • 20. Feketea G, Vlacha V, Tsiros G, et al. Vitamin D levels in asymptomatic children and adolescents with atopy during the COVID-19 era. J Pers Med. 2021;11:712
  • 21. Kang HM, Jeong DC, Suh BK, Ahn MB. The impact of the coronavirus disease-2019 pandemic on childhood obesity and vitamin D status. J Korean Med Sci. 2021;36:e21
  • 22. Yu L, Ke HJ, Che D, et al. Effect of pandemic-related confinement on vitamin D status among children aged 0-6 years in Guangzhou, China: A crosssectional study. Risk Manag Healthc Policy. 2020;13:2669-75
  • 23. Holick MF. Vitamin D deficiency. N Engl J Med. 2007;357:266-81
  • 24. Nair R, Maseeh A. Vitamin D: The “sunshine" vitamin. J Pharmacol Pharmacother. 2012;3:118-26
  • 25. Di Renzo L, Gualtieri P, Pivari F, et al. Eating habits and lifestyle changes during COVID-19 lockdown: An Italian survey. J Transl Med. 2020;18:229
  • 26. Xiang M, Zhang Z, Kuwahara K. Impact of COVID-19 pandemic on children and adolescents’ lifestyle behavior larger than expected. Prog Cardiovasc Dis. 2020;63:531-32
  • 27. Pietrobelli A, Pecoraro L, Ferruzzi A, et al. Effects of COVID-19 lockdown on lifestyle behaviors in children with obesity living in Verona, Italy: A longitudinal study. Obesity (Silver Spring). 2020;28:1382-85
  • 28. Cancello R, Soranna D, Zambra G, et al. Determinants of the lifestyle changes
  • 29. Teshome A, Adane A, Girma B, Mekonnen ZA. The impact of vitamin D level on COVID-19 infection: Systematic review and meta-analysis. Front Public Health. 2021;9:624559
  • 30. Ghasemian R, Shamshirian A, Heydari K, et al. The role of vitamin D during COVID-19 pandemic in the residents of Northern Italy. Int J Environ age of COVID-19: A systematic review and meta-analysis. Int J Clin Pract. Res Public Health. 2020;17:6287 2021;75:e14675

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18143 Teen drop.jpg admin 20 Jul, 2022 11:55 47.47 Kb 114
18142 Vit D levels dropped - clipped.jpg admin 20 Jul, 2022 09:40 36.27 Kb 181
17653 COVID dropped Vitamin D levels in teens by 3 ng.pdf PDF 2022 admin 25 May, 2022 14:14 686.19 Kb 97