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Fall and fracture rates vs Vitamin D after standardization – March 2018

Vitamin D status in relation to physical performance, falls and fractures in the Longitudinal Aging Study Amsterdam: A reanalysis of previous findings using standardized serum 25-hydroxyvitamin D values

Originally presented Spring 2017 at Vitamin D Workshop
The Journal of Steroid Biochemistry and Molecular Biology. Vol 177, March 2018, Pages 255-260 https://doi.org/10.1016/j.jsbmb.2017.09.012
N.M.Van Schoor a, M.W.Heymans a, P.Lips b


Falls and Fractures category contains the following summary



Pages listed in BOTH the categories Falls/Fracture and Meta-analysis

Falls/Fracture Intervention trials (give Vitamin D and see what happens)

13 reasons why many seniors need more vitamin D (both dose and level) - July 2023 has the following

  1. Senior skin produces 4X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptor genes as they age
    Receptors are needed to get Vitamin D in blood actually into the cells
  3. Many other Vitamin D genes decrease with age
  4. Since many gene activations are not detected by a blood test,
    more Vitamin D is often needed, especially by seniors
  5. Seniors are indoors more than when they were younger
    not as agile, weaker muscles; frail, no longer enjoy hot temperatures
  6. Seniors wear more clothing outdoors than when younger
    Seniors also are told to fear skin cancer & wrinkles
  7. Seniors often take various drugs which end up reducing vitamin D
    Some reductions are not detected by a vitamin D test of the blood
    statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
  8. Seniors often have one or more diseases that consume vitamin D
    osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
  9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
  10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
  12. Vitamin D is not as bioavailable in senior intestines
  13. Seniors with poorly functioning kidneys do not process vitamin D as well
       Seniors category has 431 items




Data is statistically significant only if compare > 12 ng to < 12 ng


  • More people were at risk for low vitamin D status after standardization of serum 25(OH)D values.
  • Associations between serum 25(OH)D and physical functioning, falls and fractures were similar after standardization.
  • Larger differences between original and standardized serum 25(OH)D values were observed in some other cohorts.
  • Standardization is of utmost importance for reaching consensus in clinical cut-offs.

The Longitudinal Aging Study Amsterdam (LASA) is an ongoing prospective cohort study in a representative sample of Dutch older persons. In previous LASA studies, lower serum 25-hydroxyvitamin D (25(OH)D) values, as assessed by a competitive protein binding assay or radioimmunoassay, have been associated with decreased physical functioning, falls and fractures. Recently, serum 25(OHD) values in LASA were standardized using the Vitamin D Standardization Program (VDSP) protocol as part of the European ODIN project. In the current manuscript, the influence of standardizing serum 25(OH)D values will be discussed using the associations with physical functioning, falls and fractures as examples.

PDF can be viewed at DeepDyve

Attached files

ID Name Comment Uploaded Size Downloads
9866 Falls Hazard.jpg admin 16 May, 2018 24.21 Kb 505
9865 Falls T3.jpg admin 16 May, 2018 23.07 Kb 499
9864 Falls T2.jpg admin 16 May, 2018 12.98 Kb 468
9863 Falls T1.jpg admin 16 May, 2018 26.99 Kb 492