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Increased risk of fracture if high level of Vitamin D (if continue to take Calcium) – umbrella analysis of meta-analyses Nov 2020

Vitamin D supplementation and fracture risk: Evidence for a U-shaped effect

Maturitas, 2020 Nov;141:63-70. doi: 10.1016/j.maturitas.2020.06.016
Panagiotis Anagnostis 1, Julia K Bosdou 2, Eustathios Kenanidis 3, Michael Potoupnis 3, Eleftherios Tsiridis 3, Dimitrios G Goulis 4

VitaminDWiki

This is one of many studies which have found that you should reduce Calcium if have high level of vitamin D
It appears that there is less/no problem when taking a Calcium from plants or take it multiple times per day

Falls and Fractures category contains the following

Falls

Left hand column section as of Nov 2024

Fracture

Items in both categories Fractures/Falls and meta-anayslis are listed here: 

 Download the PDF from sci-hub via VitaminDWiki

During the last decade, a cascade of evidence has questioned the anti-fracture efficacy of vitamin D supplementation. In general, vitamin D status, reflected by serum 25-hydroxy-vitamin D [25(OH)D] concentrations, seems to predict fracture risk and bone mineral density (BMD). Despite the well-documented detrimental effect of vitamin D deficiency on bones, vitamin D monotherapy does not seem to reduce the risk of fractures. On the other hand, high vitamin D doses, either at monthly (60,000-100,000 IU) or daily intervals (>4000 IU), appear to be harmful with regard to falls, fracture risk and BMD, especially for people without vitamin D deficiency and at low fracture risk. Therefore, a U-shaped effect of vitamin D on the musculoskeletal system may be supported by the current evidence. Vitamin D supplementation could be of value, at daily doses of at least 800 IU, co-supplemented with calcium (1000-1200 mg/day), in elderly populations, especially those with severe vitamin D deficiency [25(OH)D <25-30 nmol/L (<10-12 ng/mL)], although its anti-fracture and anti-fall efficacy is modest. Good compliance and at least 3-5 years of therapy are required.


Created by admin. Last Modification: Thursday November 26, 2020 01:46:33 GMT-0000 by admin. (Version 5)

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14611 Fracture risk u shaped sci-hub.pdf admin 26 Nov, 2020 2.41 Mb 454