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Fracture risk reduced somewhat by 800 IU of vitamin D and Calcium – meta-analysis Oct 2015

Calcium plus vitamin D supplementation and risk of fractures: an updated meta-analysis from the National Osteoporosis Foundation


Osteoporosis International DOI 10.1007/s00198-015-3386-5
C. M. Weaver • D. D. Alexander2 • C. J. Boushey3 • B. Dawson-Hughes4 •
J. M. Lappe5,6 • M. S. LeBoff7 • S. Liu8 • A. C. Looker9 • T. C. Wallace10,11 • D. D. Wang12

VitaminDWiki

This study looked ONLY at trials using 700 - 800 IU of vitamin D (and Calcium)
There are many trials which use 2,000+ IU of vitamin D – which have found much better results.

Why did this study fail to consider those high vitamin D studies?
Are they afraid of a similar problem as in Australia?
  Australia as a whole increased vitamin D consumption by 20X, then Osteoporosis visits in Australia declined by 36%

See also VitaminDWiki

Summary The aim was to meta-analyze randomized controlled trials of calcium plus vitamin D supplementation and fracture prevention. Meta-analysis showed a significant 15 % reduced risk of total fractures (summary relative risk estimate [SRRE], 0.85; 95 % confidence interval [CI], 0.73-0.98) and a 30 % reduced risk of hip fractures (SRRE, 0.70; 95 % CI, 0.56-0.87).

Introduction Calcium plus vitamin D supplementation has been widely recommended to prevent osteoporosis and subsequent fractures; however, considerable controversy exists regarding the association of such supplementation and fracture risk. The aim was to conduct a meta-analysis of randomized controlled trials [RCTs] of calcium plus vitamin D supplementation and fracture prevention in adults.

Methods A PubMed literature search was conducted for the period from July 1, 2011 through July 31, 2015. RCTs reporting the effect of calcium plus vitamin D supplementation on fracture incidence were selected from English- language studies. Qualitative and quantitative information was extracted; random-effects meta-analyses were conducted to generate summary relative risk estimates (SRREs) for total and hip fractures. Statistical heterogeneity was assessed using Cochran’s Q test and the I2 statistic, and potential for publication bias was assessed.

Results Of the citations retrieved, eight studies including 30, 970 participants met criteria for inclusion in the primary analysis, reporting 195 hip fractures and 2231 total fractures. Meta-analysis of all studies showed that calcium plus vitamin D supplementation produced a statistically significant 15 % reduced risk of total fractures (SRRE, 0.85; 95 % confidence interval [CI], 0.73-0.98) and a 30 % reduced risk of hip fractures (SRRE, 0.70; 95 % CI, 0.56-0.87). Numerous sensitivity and subgroup analyses produced similar summary associations. A limitation is that this study utilized data from subgroup analysis of the Women’s Health Initiative.

Conclusions This meta-analysis of RCTs supports the use of calcium plus vitamin D supplements as an intervention for fracture risk reduction in both community-dwelling and institutionalized middle-aged to older adults.

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