Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly.
Aging Male. 2015 Nov 10:1-6. [Epub ahead of print]
Gutiérrez-Robledo LM 1, Ávila-Funes JA 2,3, Amieva H 3, Meillon C3, Acosta JL 4,5, Navarrete-Reyes AP 2, Torres-Carrillo N 6, Muñoz-Valle JF 6, Torres-Carrillo NM1, 6.
1a Instituto Nacional de Geriatría , México, D.F. , Mexico .
2b Departamento de Geriatría , Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán , México, D.F. , Mexico .
3c Centre de recherche Inserm , U897, Bordeaux , France ; Univ Victor Segalen Bordeaux 2, Bordeaux , France .
4d Departamento de Microbiología y Patología , Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico .
5e Instituto Politécnico Nacional, Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional (CIIDIR)-Unidad Sinaloa , Sinaloa , Mexico , and.
6f Instituto de Investigación en Ciencias Biomédicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara , Guadalajara , Jalisco , Mexico.
Since vitamin D is an important regulator of muscle function, the effect of vitamin D deficiency on frailty syndrome has been recently studied. This cross-sectional study aimed to determine the association between 25(OH)-vitamin D levels and frailty status in Mexican community-dwelling elderly.
Sample of 331 community-dwelling elderly aged 70 or older, a subset of those included in the "Coyoacán cohort" were included. 25(OH)-vitamin D assay and frailty status were measured.
Mean age was 79.3 years and 54.1% were women. Those classified as frail were more likely to have
- lower Mini-Mental State Examination score (p = 0.015),
- more disability for instrumental activities of daily living (p < 0.001)
- and for activities of daily living (p < 0.001).
Serum 25(OH)-vitamin D levels were lower in the frail subgroup when compared with the non-frail one (p < 0.001). Multivariate logistic regression analyses showed a significant association between intermediate tertile [odds ratios (OR) = 4.13; 95% confidence intervals (CI) 2.00-8.56] or insufficient tertile (OR = 8.95; 95% CI 2.41-33.30) of vitamin D levels and frailty even after adjusting for potential confounders.
These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels.
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