- Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly.
- See also VitaminDWik
- VitaminDWiki - 10 reasons why seniors have low levels of vitamin D
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Association of low serum 25-hydroxyvitamin D levels with the frailty syndrome in Mexican community-dwelling elderly.
Aging Male. 2015 Nov 10:1-6. [Epub ahead of print]
Gutiérrez-Robledo LM 1, Ávila-Funes JA 2,3, Amieva H 3, Meillon C3, Acosta JL 4,5, Navarrete-Reyes AP 2, Torres-Carrillo N 6, Muñoz-Valle JF 6, Torres-Carrillo NM1, 6.
Since vitamin D is an important regulator of muscle function, the effect of vitamin D deficiency on frailty syndrome has been recently studied. This cross-sectional study aimed to determine the association between 25(OH)-vitamin D levels and frailty status in Mexican community-dwelling elderly.
Sample of 331 community-dwelling elderly aged 70 or older, a subset of those included in the "Coyoacán cohort" were included. 25(OH)-vitamin D assay and frailty status were measured.
Mean age was 79.3 years and 54.1% were women. Those classified as frail were more likely to have
- lower Mini-Mental State Examination score (p = 0.015),
- more disability for instrumental activities of daily living (p < 0.001)
- and for activities of daily living (p < 0.001).
Serum 25(OH)-vitamin D levels were lower in the frail subgroup when compared with the non-frail one (p < 0.001). Multivariate logistic regression analyses showed a significant association between intermediate tertile [odds ratios (OR) = 4.13; 95% confidence intervals (CI) 2.00-8.56] or insufficient tertile (OR = 8.95; 95% CI 2.41-33.30) of vitamin D levels and frailty even after adjusting for potential confounders.
These results suggest that older adults with low 25(OH)-vitamin D levels are associated with the probability to being frail compared with those with sufficient vitamin D levels.
- Frailty and Vitamin D - many studies
- Overview Seniors and Vitamin D
- Overview Fractures and Falls and Vitamin D
- Seniors 2.2 X more likely to walk slowly if very low vitamin D – meta-analysis Dec 2017
- Vertigo treated by Vitamin D - many studies
- Slow walking speed of youths 14 times more likely if low vitamin D - Dec 2016
- 80 percent of the characteristics of frailty associated with low vitamin D – May 2013
- Vitamin D improves muscle strength, reduces falling, and reduces frailty – review March 2015
- Frailty Call to Action: Vitamin D is one of the action items – June 2013
- Frailty and low muscle mass both associated with low vitamin D – Aug 2013
VitaminDWiki - 10 reasons why seniors have low levels of vitamin D
- Senior skin produces 3X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptor genes as they age
Receptors are needed to get Vitamin D in blood actually into the cells
- Many other Vitamin D genes decrease with age
- Since many gene activations are not detected by a blood test,
more Vitamin D is often needed, especially by seniors
- Seniors are indoors more than when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures
- Seniors wear more clothing outdoors than when younger
Seniors also are told to fear skin cancer & wrinkles
- Seniors often take various drugs which end up reducing vitamin D
Some reductions are not detected by a vitamin D test of the blood
statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
- Seniors often have one or more diseases that consume vitamin D
osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
- Seniors generally put on weight at they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
- Vitamin D is not as bioavailable in senior intestines
- Seniors with poorly functioning kidneys do not process vitamin D as well
Seniors category has
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