Toggle Health Problems and D

Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018

Serum 25-hydroxyvitamin D levels and incident falls in older women.

Osteoporos Int. 2018 Sep 25. doi: 10.1007/s00198-018-4705-4. [Epub ahead of print]
Uusi-Rasi K1, Patil R2,3, Karinkanta S2, Tokola K2, Kannus P2,4,5, Lamberg-Allardt C6, Sievänen H2.
1 The UKK Institute for Health Promotion Research, P.O. Box 30, 33501, Tampere, Finland. kirsti.uusi-rasi at uta.fi.
2 The UKK Institute for Health Promotion Research, P.O. Box 30, 33501, Tampere, Finland.
3 Department of Physiotherapy, Jehangir Hospital, Pune, Maharashtra, 411001, India.
4 Medical School, University of Tampere, Tampere, Finland.
5 Department of Orthopedics and Trauma Surgery, Tampere University Central Hospital, Tampere, Finland.
6 Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland.


800 IU of Vitamin D and exercise for 16 weeks did not reduce falls overall.
Only those women who achieved about 40 ng reduced falling - by 37%
Typically 4,000 IU is needed to achieve 40 ng level of vitamin D
Perhaps a higher percentage of women would have reduced falling if all had taken 4,000 IU
Exercise and protein also help reduce falls - see below


Note: It may have taken 6 months to respond. (Many trials last only 3 months)


Strangely: Those with D2 response fell less often than D3

Strangely: 26% of women receiving just a placebo had responses of D3 or D4

All got 800 IU, but grouped by responses D1D2D3D4
Vitamin D response nmol/L59.5 74.786.0 105.9 (42 ng)
Falls with medically attended injuries 9.6 14.2 8.0 7.2
Falls with fractures 4.1 2.7 3.4 2.0

Note: They correctly did not record fall data for the first 6 months

PDF is available free at Sci-Hub  10.1007/s00198-018-4705-4

Three hundred eighty-seven home-dwelling older women were divided into quartiles based on mean serum 25-hydroxyvitamin D (S-25(OH)D) levels. The rates of falls and fallers were about 40% lower in the highest S-25(OH)D quartile compared to the lowest despite no differences in physical functioning, suggesting that S-25(OH)D levels may modulate individual fall risk.

Vitamin D supplementation of 800 IU did not reduce falls in our previous 2-year vitamin D and exercise RCT in 70-80 year old women. Given large individual variation in individual responses, we assessed here effects of S-25(OH)D levels on fall incidence.

Irrespective of original group allocation, data from 387 women were explored in quartiles by mean S-25(OH)D levels over 6-24 months; means (SD) were 59.3 (7.2), 74.5 (3.3), 85.7 (3.5), and 105.3 (10.9) nmol/L. Falls were recorded monthly with diaries. Physical functioning and bone density were assessed annually. Negative binomial regression was used to assess incidence rate ratios (IRRs) for falls and Cox-regression to assess hazard ratios (HR) for fallers. Generalized linear models were used to test between-quartile differences in physical functioning and bone density with the lowest quartile as reference.

There were 37% fewer falls in the highest quartile, while the two middle quartiles did not differ from reference. The respective IRRs (95% CI) for falls were 0.63 (0.44 to 0.90), 0.78 (0.55 to 1.10), and 0.87 (0.62 to 1.22), indicating lower falls incidence with increasing mean S-25(OH)D levels. There were 42% fewer fallers (HR 0.58; 040 to 0.83) in the highest quartile compared to reference. Physical functioning did not differ between quartiles.

Falls and faller rates were about 40% lower in the highest S-25(OH)D quartile despite similar physical functioning in all quartiles. Prevalent S-25(OH)D levels may influence individual fall risk. Individual responses to vitamin D treatment should be considered in falls prevention.

Created by admin. Last Modification: Tuesday October 2, 2018 21:47:14 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
10621 Less likely to fall if achieved 40 ng.jpg admin 29 Sep, 2018 17:52 22.98 Kb 610
10620 800 IU fall.jpg admin 29 Sep, 2018 17:52 27.59 Kb 710