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Falls reduced by a third if achieved 40 ng level vitamin D– RCT Sept 2018

Serum 25-hydroxyvitamin D levels and incident falls in older women.

Osteoporos Int. 2018 Sep 25. doi: 10.1007/s00198-018-4705-4. [Epub ahead of print]
Uusi-Rasi K1, Patil R2,3, Karinkanta S2, Tokola K2, Kannus P2,4,5, Lamberg-Allardt C6, Sievänen H2.
1 The UKK Institute for Health Promotion Research, P.O. Box 30, 33501, Tampere, Finland. kirsti.uusi-rasi at uta.fi.
2 The UKK Institute for Health Promotion Research, P.O. Box 30, 33501, Tampere, Finland.
3 Department of Physiotherapy, Jehangir Hospital, Pune, Maharashtra, 411001, India.
4 Medical School, University of Tampere, Tampere, Finland.
5 Department of Orthopedics and Trauma Surgery, Tampere University Central Hospital, Tampere, Finland.
6 Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland.


800 IU of Vitamin D and exercise for 16 weeks did not reduce falls overall.
Only those women who achieved about 40 ng reduced falling - by 37%
Typically 4,000 IU is needed to achieve 40 ng level of vitamin D
Perhaps a higher percentage of women would have reduced falling if all had taken 4,000 IU
Exercise and protein also help reduce falls - see below


Note: It may have taken 6 months to respond. (Many trials last only 3 months)


Strangely: Those with D2 response fell less often than D3

Strangely: 26% of women receiving just a placebo had responses of D3 or D4

All got 800 IU, but grouped by responses D1D2D3D4
Vitamin D response nmol/L59.5 74.786.0 105.9 (42 ng)
Falls with medically attended injuries 9.6 14.2 8.0 7.2
Falls with fractures 4.1 2.7 3.4 2.0

Note: They correctly did not record fall data for the first 6 months

PDF is available free at Sci-Hub  10.1007/s00198-018-4705-4

Three hundred eighty-seven home-dwelling older women were divided into quartiles based on mean serum 25-hydroxyvitamin D (S-25(OH)D) levels. The rates of falls and fallers were about 40% lower in the highest S-25(OH)D quartile compared to the lowest despite no differences in physical functioning, suggesting that S-25(OH)D levels may modulate individual fall risk.

Vitamin D supplementation of 800 IU did not reduce falls in our previous 2-year vitamin D and exercise RCT in 70-80 year old women. Given large individual variation in individual responses, we assessed here effects of S-25(OH)D levels on fall incidence.

Irrespective of original group allocation, data from 387 women were explored in quartiles by mean S-25(OH)D levels over 6-24 months; means (SD) were 59.3 (7.2), 74.5 (3.3), 85.7 (3.5), and 105.3 (10.9) nmol/L. Falls were recorded monthly with diaries. Physical functioning and bone density were assessed annually. Negative binomial regression was used to assess incidence rate ratios (IRRs) for falls and Cox-regression to assess hazard ratios (HR) for fallers. Generalized linear models were used to test between-quartile differences in physical functioning and bone density with the lowest quartile as reference.

There were 37% fewer falls in the highest quartile, while the two middle quartiles did not differ from reference. The respective IRRs (95% CI) for falls were 0.63 (0.44 to 0.90), 0.78 (0.55 to 1.10), and 0.87 (0.62 to 1.22), indicating lower falls incidence with increasing mean S-25(OH)D levels. There were 42% fewer fallers (HR 0.58; 040 to 0.83) in the highest quartile compared to reference. Physical functioning did not differ between quartiles.

Falls and faller rates were about 40% lower in the highest S-25(OH)D quartile despite similar physical functioning in all quartiles. Prevalent S-25(OH)D levels may influence individual fall risk. Individual responses to vitamin D treatment should be considered in falls prevention.

Created by admin. Last Modification: Tuesday October 2, 2018 21:47:14 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
10621 Less likely to fall if achieved 40 ng.jpg admin 29 Sep, 2018 22.98 Kb 662
10620 800 IU fall.jpg admin 29 Sep, 2018 27.59 Kb 792