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Bone fractures reduced by a minimum of 800 IU vitamin D and Calcium – meta-meta-analysis March 2014

Vitamin D supplements with or without calcium to prevent fractures

BoneKEy Reports (2014) 3, Article number: 512 (2014) doi:10.1038/bonekey.2014.7
Received 02 September 2013 Accepted 05 November 2013 Published online 05 March 2014
Paul Lips, Evelien Gielen & Natasja M van Schoor

Vitamin D deficiency is associated with fractures. This relationship is biologically plausible. The results of 19 randomized clinical trials with vitamin D with or without calcium show varying results: a decreased fracture incidence in 7, neutral in 10 trials, whereas 2 trials with a high dose of vitamin D once per year showed an increased fracture incidence. In three out of four well-powered trials that used recommended doses of vitamin D 700–1000 IU per day, vitamin D supplementation did not significantly influence fracture risk. In one of these trials, a statistically significant fracture reduction was observed in nursing home residents having severe vitamin D deficiency, low calcium intake and good compliance.
Thirteen meta-analyses were done, and 11 of these showed a significantly decreased fracture incidence in the supplemented groups. Vitamin D alone was not effective, studies combining vitamin D and calcium showed inconsistent results. Analyses for vertebral fractures were negative in all cases. In conclusion, a vitamin D supplement of 800 IU per day in combination with calcium may decrease the incidence of non-vertebral fractures, especially in persons in the older age groups having low-baseline vitamin D status and low calcium intake and showing good compliance.
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PDF is attached at the bottom of this page

Comment by VitaminDWiki

Yes, need extra Calcium with low amount of vitamin D, but Calcium should be minimized with high level of vitamin D
Note: Following chart which shows that supplement suppliers reduce the Calcium as they increase the Vitamin D in pills

See also VitaminDWiki

released Nov 30, 2010

Meta-analysis of Falls and Fracture in VitaminDWiki

Attached files

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3903 T2B.jpg admin 14 May, 2014 167.71 Kb 1294
3902 T2A.jpg admin 14 May, 2014 189.55 Kb 1340
3901 Fractures Ca Lips.pdf admin 14 May, 2014 249.47 Kb 889