Fall and fracture rates vs Vitamin D after standardization – March 2018

Vitamin D status in relation to physical performance, falls and fractures in the Longitudinal Aging Study Amsterdam: A reanalysis of previous findings using standardized serum 25-hydroxyvitamin D values

Originally presented Spring 2017 at Vitamin D Workshop
The Journal of Steroid Biochemistry and Molecular Biology. Vol 177, March 2018, Pages 255-260 https://doi.org/10.1016/j.jsbmb.2017.09.012
N.M.Van Schoor a, M.W.Heymans a, P.Lips b


Falls and Fractures category contains the following summary



Pages listed in BOTH the categories Falls/Fracture and Meta-analysis

Falls/Fracture Intervention trials (give Vitamin D and see what happens)

10 reasons why seniors need more vitamin D has the following

  1. Senior skin produces 3X less Vitamin D for the same sun intensity
  2. Seniors have fewer vitamin D receptors as they age
  3. Seniors are indoors more than than when they were younger
    • not as agile, weaker muscles; frail, no longer enjoy hot temperatures
    • (if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc.
  4. Seniors wear more clothing outdoors than when younger
    • Seniors also are told to fear skin cancer/wrinkles
  5. Seniors often take various drugs which reduce vitamin D
  6. Seniors often have one or more diseases which consume vitamin D
  7. Seniors generally put on weight at they age - and a heavier body requires more vitamin D
  8. Seniors often (40%) have fatty livers – which do not process vitamin D as well
  9. Reduced stomach acid ==>less Magnesium needed to utilize vitamin D
    (would not show up on vitamin D test)
  10. Seniors with poorly functioning kidneys do not process vitamin D as well
    (would not show up on vitamin D test) 2009 full text online  Also PDF 2009
  11. Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)




Data is statistically significant only if compare > 12 ng to < 12 ng


  • More people were at risk for low vitamin D status after standardization of serum 25(OH)D values.
  • Associations between serum 25(OH)D and physical functioning, falls and fractures were similar after standardization.
  • Larger differences between original and standardized serum 25(OH)D values were observed in some other cohorts.
  • Standardization is of utmost importance for reaching consensus in clinical cut-offs.

The Longitudinal Aging Study Amsterdam (LASA) is an ongoing prospective cohort study in a representative sample of Dutch older persons. In previous LASA studies, lower serum 25-hydroxyvitamin D (25(OH)D) values, as assessed by a competitive protein binding assay or radioimmunoassay, have been associated with decreased physical functioning, falls and fractures. Recently, serum 25(OHD) values in LASA were standardized using the Vitamin D Standardization Program (VDSP) protocol as part of the European ODIN project. In the current manuscript, the influence of standardizing serum 25(OH)D values will be discussed using the associations with physical functioning, falls and fractures as examples.

PDF can be viewed at DeepDyve

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