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800 IU Vitamin D does not help heart – meta-analysis Aug 2011

Vitamin D and Cardiovascular Outcomes: A Systematic Review and Meta-Analysis

Mohamed B. Elamin, Nisrin O. Abu Elnour, Khalid B. Elamin, Mitra M. Fatourechi, Aziz A. Alkatib, Jaime P. Almandoz, Hau Liu, Melanie A. Lane, Rebecca J. Mullan, Ahmad Hazem, Patricia J. Erwin, Donald D. Hensrud, Mohammad Hassan Murad murad.mohammad at mayo.edu. , Victor M. Montori
Knowledge and Evaluation Research Unit (M.B.E., N.O.A.E., M.M.F., A.A.A., M.A.L., R.J.M., A.H., P.J.E., M.H.M., V.M.M.), Mayo Clinic, Rochester, Minnesota 55905;
Department of Medicine (K.B.E.), Case Western Reserve University, Metrohealth Medical Center, Cleveland, Ohio 44109;
Division of Endocrinology, Diabetes, Metabolism, Nutrition (J.P.A., V.M.M.), Mayo Clinic, Rochester, Minnesota 55905;
Division of Endocrinology and Metabolism (H.L.), Santa Clara Valley Medical Center, San Jose, California 95128; and D
ivision of Preventive, Occupational, and Aerospace Medicine (A.H., D.D.H., M.H.M.), Mayo Clinic, Rochester, Minnesota 55905

Context: Several studies found association between vitamin D levels and hypertension, coronary artery calcification, and heart disease.

Objective: The aim of this study was to summarize the evidence on the effect of vitamin D on cardiovascular outcomes.

Design and Methods: We searched electronic databases from inception through August 2010 for randomized trials. Reviewers working in duplicate and independently extracted study characteristics, quality, and the outcomes of interest. Random-effects meta-analysis was used to pool the relative risks (RR) and the weighted mean differences across trials.

Results: We found 51 eligible trials with moderate quality. Vitamin D was associated with nonsignificant effects on the patient-important outcomes of death (RR, 0.96; 95% confidence interval (CI), 0.93, 1.00; P = 0.08), myocardial infarction (RR, 1.02; 95% CI, 0.93, 1.13; P = 0.64), and stroke (RR, 1.05; 95% CI, 0.88, 1.25; P = 0.59). These analyses were associated with minimal heterogeneity. There were no significant changes in the surrogate outcomes of lipid fractions, glucose, or diastolic or systolic blood pressure. The latter analyses were associated with significant heterogeneity, and the pooled estimates were trivial in absolute terms

Conclusions: Trial data available to date are unable to demonstrate a statistically significant reduction in mortality and cardiovascular risk associated with vitamin D. The quality of the available evidence is low to moderate at best.

Received February 14, 2011. Accepted May 23, 2011.
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PDF is attached at bottom of page

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Note that virtually all of the studies were with 800 IU of vitamin D daily.

800 IU is not enough to make a difference

And, while there were a few studies which might have had enough vitamin D to make a difference,
the studies were all averaged together - The meta-analysis did not care much vitamin D was taken.
Also, did not care Vitamin D2 vs Vitamin D3

See VitaminDWiki

Attached files

ID Name Comment Uploaded Size Downloads
695 Vitamin D and Cardiovascular - 2011.pdf PDF admin 16 Aug, 2011 12:36 148.37 Kb 728
694 Vitamin D and cardiovascular.png table admin 16 Aug, 2011 12:34 152.62 Kb 921
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