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Risk of Cardiac failure reduced 20 percent by 800 IU of vitamin D and Calcium – meta-analysis July 2014

Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis.

Am J Clin Nutr. 2014 Jul 23. pii: ajcn.082602.
Ford JA1, MacLennan GS1, Avenell A1, Bolland M1, Grey A1, Witham M1; for the RECORD Trial Group.
1From the Health Services Research Unit, University of Aberdeen, Aberdeen, United Kingdom (JAF, GSM, and AA); the Department of Medicine, University of Auckland, Auckland, New Zealand (MB and AG); and the Section of Aging and Health, University of Dundee, Dundee, United Kingdom (MW).

Low 25-hydroxyvitamin D status has been associated with increased cardiovascular events in epidemiologic studies.

OBJECTIVE: We assessed whether vitamin D supplementation reduces cardiac failure, myocardial infarction (MI), and stroke through an analysis of the Randomised Evaluation of Calcium Or vitamin D (RECORD) randomized controlled trial (RCT), a systematic review, and a meta-analysis.

DESIGN: Two analyses were undertaken. The first analysis was a trial analysis. The RECORD was a factorial RCT that compared vitamin D3 (800 IU/d), calcium (1000 mg/d), vitamin D plus calcium, and a placebo. Cardiovascular events were collected throughout the trial and 3-y posttrial follow-up. Data were analyzed by using Cox regression. The second analysis was a systematic review. MEDLINE, EMBASE, CENTRAL, conference abstracts, and ongoing trials were searched for RCTs that evaluated vitamin D from 1980 to 2013. RCTs with ≥1 y of follow-up and participants mean or median age ≥60 y were included. Meta-analyses were based on a Bayesian fixed-effects model by using a complementary log-log link function to account for varying lengths of follow-up.

RESULTS: In the trial analysis, we showed that, for the 5292 participants in the RECORD trial, HRs (95% CIs) for vitamin D compared with no vitamin D for cardiac failure, MI, and stroke were 0.75 (0.58, 0.97), 0.97 (0.75,1.26), and 1.06 (0.8, 1.32), respectively. Twenty-one studies met the inclusion criteria for the systematic review (n = 13,033). Estimated HRs [credible intervals (CrIs)] for vitamin D compared with the placebo or control for on-study events for cardiac failure, MI, and stroke were 0.82 (0.58, 1.15), 0.96 ( 0.83, 1.10), and 1.07 (0.91, 1.29), respectively.

CONCLUSION: Vitamin D supplementation might protect against cardiac failure in older people but does not appear to protect against MI or stroke.

© 2014 American Society for Nutrition, PMID: 25057156 PDF is at the bottom of this page

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Overview Cardiovascular and vitamin D

315 studies cited this study as of Oct 2022 Google Scholar

  • Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials A Meta-analysis - June 2019 doi:10.1001/jamacardio.2019.1870 FREE PDF ignoring dose size Vitamin D did not help
  • Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis - July 2018 https://doi.org/10.3389/fcvm.2018.00087 FREE PDF appeared to ignore dose size
  • Hypovitaminosis D and cardiovascular outcomes: A systematic review and meta-analysis - June 2022, https://doi.org/10.1016/j.ijcha.2022.101019 FREE PDF
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  • Links between Vitamin D Deficiency and Cardiovascular Diseases - Feb 2015, http://dx.doi.org/10.1155/2015/109275, FREE PDF
  • Effect of Monthly High-Dose Vitamin D Supplementation on Cardiovascular Disease in the Vitamin D Assessment Study - A Randomized Clinical Trial" July 2017 doi:10.1001/jamacardio.2017.0175
    • monthly 100,000 did not prevent
  • Vitamin D and cardiovascular disease prevention May 2016
  • "Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials" Dec 2017, doi.org/10.1016/S2213-8587(17)30357-1
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  • "Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data" July 2017 doi.org/10.1371/journal.pone.0180512 FREE PDF
  • "Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials A Meta-analysis" June 2019 doi:10.1001/jamacardio.2019.1870 no Cardio risk PREVENTION
  • "Vitamin D status and cardiovascular outcome" June 2019 FREE PDF
    • "it is still unclear if vitamin D deficiency has a causative role in cardiovascular diseases"

Search Google Scholar for "cardiovascular disease" prevention "vitamin D" Nov 2019 included

  • "Vitamin D Supplementation, Serum 25(OH)D Concentrations and Cardiovascular Disease Risk Factors: A Systematic Review and Meta-Analysis" July 2018 doi.org/10.3389/fcvm.2018.00087 FREE PDF
    • "vitamin D supplementation may act to protect against CVD through improving risk factors, including high blood pressure, elevated PTH, dyslipidemia, and inflammation"
  • "Vitamin D and cardiovascular diseases: Causality" Jan 2018 Wimalawansa, doi.org/10.1016/j.jsbmb.2016.12.016
    • "Current data support the importance of adequate vitamin D in preventing cardiovascular and other chronic diseases"
  • "Vitamin D supplementation does not improve CVD risk factors in vitamin D-insufficient subjects" June 2018 doi.org/10.1530/EC-18-0144 FREE PDF
    • 20,000 IU per week does not prevent (after small loading dose)
  • "The Demise of Vitamin D for Cardiovascular Prevention" June 2019 doi:10.1001/jamacardio.2019.1906

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