Effect of vitamin D on postoperative atrial fibrillation in patients who underwent coronary artery bypass grafting: A systematic review and Meta-analysis
J Cardiol. 2023 May 24;S0914-5087(23)00113-2. doi: 10.1016/j.jjcc.2023.05.007
Ishaque Hameed 1, Shanza Malik 1, Khushboo Nusrat 1, Omer Mustafa Siddiqui 1, Mohammad Omer Khan 1, Samar Mahmood 1, Areeba Memon 2, Muhammad Shariq Usman 3, Tariq Jamal Siddiqi 3
Background: Vitamin D insufficiency/deficiency has been identified as a risk factor for postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG). This is associated with significantly increased morbidity and mortality leading to not only prolonged hospital and intensive care unit (ICU) stay, but increased risk of stroke, heart failure, dementia, and long-term atrial fibrillation. This analysis aims to evaluate the efficacy of vitamin D supplementation in preventing POAF in patients undergoing CABG.
Methods: We searched PubMed, Cochrane Central Register of Controlled Trials and SCOPUS from inception to June 2022 for randomized controlled trials (RCTs). The outcome of interest was the incidence of POAF. Secondarily, we analyzed the length of ICU stay, length of hospital stay, cardiac arrest, cardiac tamponade, and blood transfusion. Results were pooled using a random-effect model. Three RCTs consisting of 448 patients were included.
Results: Our results suggest that vitamin D significantly reduced the incidence of POAF (RR: 0.60; 95 % CI: 0.40, 0.90; p = 0.01; I2 = 8 %).
It was also observed that vitamin D significantly reduced the duration of ICU stay (WMD: -1.639; 95 % CI: -1.857, -1.420; p < 0.00001).
Furthermore, the length of hospital stay (WMD: -0.85; 95 % CI: -2.14, 0.43; p = 0.19; I2 = 87 %) was also reduced, however, the result was not significant.
Conclusion: Our pooled analysis suggests that vitamin D prevents POAF. Future large-scale randomized trials are needed to confirm our results.
VitaminDWiki – Trauma and surgery category contains
Trauma and Surgery category hasLarge dose Vitamin D before surgery was found to help by 35 studies
Vitamin D is needed before most surgeries – many studies and RCTs
4.8 X more likely to die within 28 days of ICU if low Vitamin D - Jan 2024
Sepsis is both prevented and treated by Vitamin D - many studies
Thyroidectomy and Vitamin D - many studies
Orthopaedic surgeries need Vitamin D – many studies
Cancer - After diagnosis chemotherapy
TBI OR "Traumatic Brain Injury - 21 in title as of Sept 2022
Superbug (Clostridium difficile) Infections strongly associated with low vitamin D - many studies
Glutamine and Omega-3 have also been proven to help several traumas/surgeries
Note: Vitamin D also prevents the need for various surgeries and Omega-3 prevents many concussions/TBI
Trauma and Surgery is associated with 22 other VitaminDWiki categories
Such as loading dose 33, Mortality 23, Infant-Child 21 Intervention 19 Cardiovascular 13, Injection 13 in Sept 2022
VitaminDWiki - 15 studies in both categories Cardiovascular and Trauma-Surgery
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Afib 40% less likely after heart by-pass if have enough Vitamin D – meta-analysis May 2023
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Surgeries to re-establish blood in brain, heart, etc. are far more successful with high Vitamin D levels – March 2022
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Vitamin D levels dropped 42 percent immediately after pediatric cardiac surgery – Dec 2019
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Getting Vitamin D before heart surgery prevented Afib in those who had been deficient – July 2018
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Heart attack ICU costs cut in half by Vitamin D – Oct 2018
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3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
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Open Heart Surgery associated with low vitamin D, but not if 150,000 IU before surgery – RCT March 2018
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Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
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Cardiac rehabilitation had more power if more than 20 nanograms of vitamin D – April 2015
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Congenital Heart problems - vitamin D levels drop even lower after surgery, loading dose probably required - thesis 2015
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Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
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Higher vitamin D levels associated with fewer vein clots decades later– Jan 2013
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CV event 56 percent more likely after vascular surgery if low on vitamin D – Oct 2011
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Vitamin D helps organ transplant - many studies
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Bypass surgery and vitamin D – Nov 2010
22+ VitaminDWiki pages with AFIB or FIBRILATION in title
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Items found: 23
Afib 40% less likely after heart by-pass if have enough Vitamin D – meta-analysis May 2023
403 visitors, last modified 27 May, 2023,
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- Afib 40% less likely after heart by-pass if have enough Vitamin D – meta-analysis May 2023
- Surgeries to re-establish blood in brain, heart, etc. are far more successful with high Vitamin D levels – March 2022
- Vitamin D levels dropped 42 percent immediately after pediatric cardiac surgery – Dec 2019
- Getting Vitamin D before heart surgery prevented Afib in those who had been deficient – July 2018
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
- 3 days of Omega-3 before cardiac surgery reduced risk of post-op bleeding by half – RCT March 2018
- Open Heart Surgery associated with low vitamin D, but not if 150,000 IU before surgery – RCT March 2018
- Omega-3 reduced time in hospital and atrial fibrillation after cardiac surgery – meta-analysis May 2016
- Cardiac rehabilitation had more power if more than 20 nanograms of vitamin D – April 2015
- Congenital Heart problems - vitamin D levels drop even lower after surgery, loading dose probably required - thesis 2015
- Almost 6X more likely to die after coronary bypass if vitamin D deficient – Dec 2012
- Higher vitamin D levels associated with fewer vein clots decades later– Jan 2013
- CV event 56 percent more likely after vascular surgery if low on vitamin D – Oct 2011
- Vitamin D helps organ transplant - many studies
- Bypass surgery and vitamin D – Nov 2010
22+ VitaminDWiki pages with AFIB or FIBRILATION in title
This list is automatically updated
| 403 visitors, last modified 27 May, 2023, |