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CAD patients with low vitamin D were 1.6 X more likely to die – 27th meta-analysis Aug 2022


Predictive value of 25-hydroxyvitamin D level in patients with coronary artery disease: A meta-analysis

Front Nutr. 2022 Aug 10;9:984487. doi: 10.3389/fnut.2022.984487
Hailing Zhang 1 , Pei Wang 2 , Yu Jie 2 , Yimeng Sun 2 , Xiaoyan Wang 1 , Yu Fan 2

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Background: A consensus has not been made about the predictive value of blood vitamin D level in patients with coronary artery disease (CAD). This meta-analysis aimed to assess the association between blood 25-hydroxyvitamin D level and adverse outcomes in patients with CAD.

Methods: Two independent authors searched the articles indexed in PubMed and Embase databases until June 28, 2022. Cohort studies or post-hoc analysis randomized trials evaluating the value of 25-hydroxyvitamin D level in predicting cardiovascular or all-cause mortality, and major adverse cardiovascular events ([MACEs] including

  • Death,
  • non-fatal myocardial infarction,
  • heart failure,
  • revascularization,
  • stroke, etc.) were included.

Results: The literature search identified 13 eligible studies for our analysis, including 17,892 patients with CAD. Meta-analysis showed that the pooled adjusted risk ratio (RR) was 1.60 (95% confidence intervals [CI] 1.35-1.89) for all-cause mortality, 1.48 (95% CI 1.28-1.71) for cardiovascular mortality, and 1.33 (95% CI 1.18-1.49) for MACEs. Leave-out one study sensitivity analysis suggested that the predictive values of blood 25-hydroxyvitamin D level were reliable.

Conclusions: Low blood 25-hydroxyvitamin D level is possibly an independent predictor of cardiovascular or all-cause mortality and MACEs in patients with CAD. Baseline 25-hydroxyvitamin D level may provide useful information in CAD patients.
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VitaminDWiki - Cardiovascular category contains

472 items In Cardiovascular category

Cardiovascular category is associated with other categories: Diabetes 31, Omega-3 31 , Vitamin K 25 , Intervention 22 . Mortality 20 , Skin - Dark 18 , Magnesium 17 , Calcium 14 , Hypertension 14 , Trauma and surgery 13 , Stroke 13 , Kidney 12 , Metabolic Syndrome 11 , Seniors 10 , Pregnancy 8 as of Aug 2022


VitaminDWiki - 36 studies in both categories Cardiovascular and Meta-analysis

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Created by admin. Last Modification: Monday August 29, 2022 14:52:36 GMT-0000 by admin. (Version 7)

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18355 CAD 1.6.jpg admin 29 Aug, 2022 13:54 23.40 Kb 59
18354 fnut-09-984487_CompressPdf.pdf PDF 2022 admin 29 Aug, 2022 13:51 276.44 Kb 14