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Small or infrequent doses of vitamin D do not reduce heart failure much – meta-analysis Jan 2018

Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials.

Sci Rep. 2018 Jan 18;8(1):1169. doi: 10.1038/s41598-018-19708-0.

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Cardiovascular category starts with the following

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Meta-analyses

Omega-3 Helps

A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues

Cholesterol, Statins

The Meta-analysis of Cardiovascular and Vitamin D

See also PubMed (behind paywallSerum 25-hydroxyvitamin D and the risk of cardiovascular disease: dose-response meta-analysis of prospective studies
April 2017, 34 publications with 180,667 participants, 10% less likely for each 10ng higher level of vitamin D

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Rodriguez AJ1, Mousa A2, Ebeling PR1, Scott D1, de Courten B3.

  • 1 Bone and Muscle Health Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
  • 2 Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia.
  • 3 Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia. barbora.decourten at monash.edu.

Vitamin D is reported to have anti-inflammatory properties; however the effects of vitamin D supplementation on inflammation in patients with heart failure (HF) have not been established. We performed a systematic review and meta-analysis examining effects of vitamin D supplementation on inflammatory markers in patients with HF. MEDLINE, CINAHL, EMBASE, All EBM, and Clinical Trials registries were systematically searched for RCTs from inception to 25 January 2017. Two independent reviewers screened all full text articles (no date or language limits) for RCTs reporting effects of vitamin D supplementation (any form, route, duration, and co-supplementation) compared with placebo or usual care on inflammatory markers in patients with heart failure. Two reviewers assessed risk of bias and quality using the grading of recommendations, assessment, development, and evaluation approach. Seven studies met inclusion criteria and six had data available for pooling (n = 1012). In meta-analyses, vitamin D-supplemented groups had lower concentrations of tumor necrosis factor-alpha (TNF-α) at follow-up compared with controls (n = 380; p = 0.04). There were no differences in C-reactive protein (n = 231), interleukin (IL)-10 (n = 247) or IL-6 (n = 154) between vitamin D and control groups (all p > 0.05). Our findings suggest that vitamin D supplementation may have specific, but modest effects on inflammatory markers in HF.

Created by admin. Last Modification: Saturday November 24, 2018 13:20:03 GMT-0000 by admin. (Version 6)

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ID Name Comment Uploaded Size Downloads
10897 Meta cardio.jpg admin 24 Nov, 2018 12:52 41.43 Kb 96
10896 inflammatory markers meta-analysis.pdf PDF 2018 admin 24 Nov, 2018 12:49 1.72 Mb 62
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